Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
Natural
bioactive
compounds
from
plants
exhibit
substantial
pharmacological
potency
and
therapeutic
value.
However,
the
development
of
most
plant
is
hindered
by
low
solubility
instability.
Conventional
pharmaceutical
forms,
such
as
tablets
capsules,
only
partially
overcome
these
limitations,
restricting
their
efficacy.
With
recent
nanotechnology,
nanocarriers
can
enhance
bioavailability,
stability,
precise
intracellular
transport
compounds.
Researchers
are
increasingly
integrating
nanocarrier‐based
drug
delivery
systems
(NDDS)
into
natural
with
significant
success.
Moreover,
products
benefit
nanotechnological
enhancement
contribute
to
innovation
optimization
via
self‐assembly,
grafting
modifications,
biomimetic
designs.
This
review
aims
elucidate
collaborative
reciprocal
advancement
achieved
botanical
products,
compounds,
polysaccharides,
proteins,
extracellular
vesicles.
underscores
salient
challenges
in
nanomedicine,
encompassing
long‐term
safety
evaluations
nanomedicine
formulations,
targeting
mechanisms,
biodistribution
complexities,
hurdles
clinical
translation.
Further,
this
study
provides
new
perspectives
leverage
nanotechnology
promoting
for
nanomedical
applications
guiding
progression
NDDS
toward
enhanced
efficiency,
precision,
safety.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Nanotechnology
Biology
Nanoscale
Systems
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 10023 - 10043
Опубликована: Сен. 1, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
represents
a
significant
global
health
burden,
exhibiting
strong
correlation
with
insulin
resistance,
obesity,
and
type
2
diabetes
(T2DM).
Despite
the
severity
of
hepatic
steatosis
in
T2DM
patients,
no
specific
drugs
have
been
approved
for
clinical
treatment
disease.
Tangerine
peel
is
one
kind
popular
functional
food
reported
to
possess
hypoglycemic
lipid-lowering
potential.
In
this
study,
we
investigated
effects
Tangerine-peel-derived
exosome-like
nanovesicles
(TNVs)
on
lipotoxicity
associated
T2DM.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 2, 2025
Diacylglycerol
kinases
(DGKs)
phosphorylate
diacylglycerol
to
generate
phosphatidic
acid,
which
plays
important
roles
in
intracellular
signal
transduction.
DGKα
is
reportedly
associated
with
progression
of
tumors,
including
hepatocellular
carcinomas,
but
its
relationship
liver
regeneration
has
not
been
examined.
The
purpose
this
research
elucidate
the
role
regeneration.
Here,
we
provide
a
detailed
examination
C57BL/6
wild-type
and
knockout
(KO)
mice
subjected
70%
partial
hepatectomy
(70%
PH)
modeling,
survival
rates,
hematological
marker
gene
expression
levels,
histological
analyses
factors
related
Following
PH,
KO
produce
higher
levels
hepatobiliary
enzymes
have
incidence
jaundice
compared
mice,
death
rate
~
40%.
Furthermore,
they
exhibit
impaired
glycogen
lipid
consumption,
low
energy
charge,
hepatocyte
hypertrophy
disorder,
accompanied
by
significantly
reduced
proliferating
cell
nuclear
antigen
cyclin
D.
We
conclude
that
key
molecule
post-PH
process
may
potential
as
therapeutic
target
for
acceleration
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Plant
derived
exosome-like
nanoparticles
(PELNs)
are
membrane
structures
isolated
from
different
plants,
which
encapsulate
many
active
substances
such
as
proteins,
lipids,
and
nucleic
acids,
exert
a
substantial
influence
on
physiological
processes
plant
growth
development,
self-defense,
tissue
repair.
Compared
with
synthetic
mammalian
cell
exosomes
(MDEs),
PELNs
have
lower
toxicity
immunogenicity
possess
excellent
biocompatibility.
The
intrinsic
properties
of
establish
robust
basis
for
their
applications
in
the
therapeutic
management
diverse
array
pathologies.
It
is
worth
mentioning
that
good
biological
targeting,
promotes
them
to
load
deliver
drugs
specific
tissues,
offering
superior
development
pathway
construction
new
drug
delivery
system
(DDS).
Glucose
lipid
metabolism
vital
life
process
body's
energy
material
supply.
maintenance
homeostatic
balance
provides
fundamental
ability
adjust
modifications
both
its
internal
external
environment.
Conversely,
imbalance
can
lead
range
severe
metabolic
disorders.
This
work
comprehensive
overview
extraction
representation
methods
PELNs,
transportation
storage
characteristics,
agents
direct
treatment
vehicles
enhance
nutrition
health.
Additionally,
it
examines
efficacy
practical
addressing
abnormalities
glucose
metabolism.
Finally,
combined
above
contents,
paper
summarizes
conceptual
framework
better
application
clinical
disease
treatment.
Journal of Traditional and Complementary Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 1, 2024
Astragali
Radix
has
been
widely
used
in
traditional
Chinese
medicine
to
treat
diabetes
and
a
variety
of
other
diseases.
This
study
aims
evaluate
the
alleviating
effects
mechanisms
Astragalus
mongholicus
Polysaccharide
(mAPS)
against
diet
combined
with
streptozotocin
(STZ)-induced
Type
2
Diabetes
Mellitus
(T2DM).
T2DM
rats
were
orally
administrated
either
200
mg/kg
mAPS
or
300
Metformin
(MET)
once
daily
for
four
weeks.
Body
weight
Fasting
Blood
Glucose
(FBG)
detected
every
6
days.
Serum
fasting
insulin
(FINS)
was
measured
by
ELISA
homeostatic
model
assessment
resistance
(HOMA-IR)
calculated
accordingly.
Histological
change
studied
Hematoxylin
eosin
(HE)
staining.
16S
rDNA
sequencing
detect
changes
gut
microbiota.
Oral
administration
significantly
decreased
body
weight,
FBG,
HOMA-IR
(p<0.05).
Moreover,
HE
staining
showed
that
could
alleviate
histological
distortion
liver
pancreas.
Treatment
elevated
hepatic
levels
phosphatidylinositol-3
kinase
(PI3K),
phospho-protein
B
(AKT),
glucose
transporter
type
4
(GLUT4),
while
reducing
phospho-nuclear
factor
kappa-B
(NF-κB),
Toll-like
receptor
(TLR4),
tumor
necrosis
factor-α
(TNF-α),
interleukin-6
(IL-6),
interleukin-1β
(IL-1β)
Furthermore,
supplementation
reverse
ratio
Firmicutes/Bacteroidetes
(F/B)
reduce
abundance
Clostridia
Proteobacteria
These
results
indicate
have
potential
enhance
sensitivity
diabetic
modifying
microbiota
controlling
glycolipid
metabolism
inflammation.
Plant-derived
extracellular
vesicles
(EVs)
are
promising
therapeutic
agents
owing
to
their
natural
abundance,
accessibility,
and
unique
biological
properties.
This
review
provides
a
comprehensive
exploration
of
the
potential
plant-derived
EVs
emphasizes
anti-inflammatory,
antimicrobial,
tumor-inhibitory
effects.
Here,
we
discussed
advancements
in
isolation
purification
techniques,
such
as
ultracentrifugation
size-exclusion
chromatography,
which
critical
for
maintaining
functional
integrity
these
nanovesicles.
Next,
investigated
diverse
administration
routes
carefully
weighed
respective
advantages
challenges
related
bioavailability
patient
compliance.
Moreover,
elucidated
multifaceted
mechanisms
action
EVs,
including
roles
anti-inflammation,
antioxidation,
antitumor
activity,
modulation
gut
microbiota.
We
also
impact
on
specific
diseases
cancer
inflammatory
bowel
disease,
highlighting
importance
addressing
current
production
scalability,
regulatory
compliance,
immunogenicity.
Finally,
proposed
future
research
directions
optimizing
EV
extraction
developing
targeted
delivery
systems.
Through
efforts,
envision
seamless
integration
into
mainstream
medicine,
offering
safe
potent
alternatives
across
various
medical
disciplines.
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2608 - 2608
Опубликована: Ноя. 14, 2024
Type
2
diabetes
mellitus
(T2DM)
is
a
metabolic
disorder,
and
urinary
exosomal
microRNAs
(miRNAs)
were
utilized
as
potential
disease
prediction
or
diagnostic
biomarkers
in
numerous
studies.
This
study
investigated
the
differential
expression
of
miRNAs
between
non-diabetes
(NDM)
individuals
those
with
T2DM.
Kinases and Phosphatases,
Год журнала:
2024,
Номер
2(3), С. 279 - 293
Опубликована: Сен. 20, 2024
Obesity
has
become
a
global
epidemic,
contributing
to
various
metabolic
diseases.
Despite
existing
therapies,
the
need
investigate
new
molecular
targets
combat
obesity-associated
pathologies
persists.
Glycogen
Synthase
Kinase-3
(GSK-3),
serine/threonine
kinase
with
two
paralogs
(GSK-3α
and
GSK-3β),
emerged
as
critical
player
in
such
type
2
diabetes
(T2D),
cardiovascular
diseases
(CVDs).
However,
its
ubiquitous
dynamic
expression
complex
context-dependent
signaling
pathways
present
challenges
understanding
precise
role
perturbations.
In
review,
we
will
highlight
specific
proposed
mechanisms
via
which
GSK-3
impact
T2D,
diabetic
cardiomyopathy
(DCM),
cognitive
impairment,
hallmark
of
Alzheimer’s
disease
(AD).
We
also
studies
delineating
GSK-3s
using
either
inhibitors
or
non-pharmacological
compounds
inhibit/taper
activity
Thus,
primary
goal
this
review
is
recent
findings
regulation/dysregulation
GSK-3α/β
tissues
heart,
liver,
skeletal
muscle,
pancreas,
brain,
adipose
tissue
that
undergo
morphological
changes
diet-induced
obesity
predisposes
obese
individuals
numerous
devastating
chronic
conditions
by
overactivity.
