Developing fibrin-based biomaterials/scaffolds in tissue engineering

Bioactive Materials, Год журнала: 2024, Номер 40, С. 597 - 623

Опубликована: Авг. 15, 2024

Tissue engineering technology has advanced rapidly in recent years, offering opportunities to construct biologically active tissues or organ substitutes repair even enhance the functions of diseased and organs. Tissue-engineered scaffolds rebuild extracellular microenvironment by mimicking matrix. Fibrin-based possess numerous advantages, including hemostasis, high biocompatibility, good degradability. Fibrin provide an initial matrix that facilitates cell migration, differentiation, proliferation, adhesion, also play a critical role cell-matrix interactions. are now widely recognized as key component tissue engineering, where they can facilitate defect repair. This review introduces properties fibrin, its composition, structure, biology. In addition, modification cross-linking modes fibrin discussed, along with various forms commonly used engineering. We describe biofunctionalization fibrin. provides detailed overview use applications skin, bone, nervous tissues, novel insights into future research directions for clinical treatment.

Язык: Английский

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Chitin nanofibrils assisted 3D printing all-chitin hydrogels for wound dressing

Carbohydrate Polymers, Год журнала: 2024, Номер 334, С. 122028 - 122028

Опубликована: Март 6, 2024

Язык: Английский

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Nanomaterials-incorporated polymeric microneedles for wound healing applications

International Journal of Pharmaceutics, Год журнала: 2024, Номер 659, С. 124247 - 124247

Опубликована: Май 22, 2024

Язык: Английский

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Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 6, 2025

Seawater-immersed wounds can be threatened by high pH, permeability and infection, which may lead to the development of chronic wounds. The present study develops an aggregation strategy for rapid preparation α-lipoic acid (LA)-based bioadhesives at room temperature with strong underwater adhesion emergency treatment trauma in maritime activities. are fabricated from LA, MXene Ag+ through their supramolecular interactions, rapidly formed mild environments, showing interface without adhesive failure caused depolymerization, while exhibiting mechanical self-reinforcing. To further improve strength, formation MXene/Ag+/LA interactions was integrated into poly(2-hydroxyethyl methacrylate) (pHEMA) electrospinning manufacture electrospun film strength as 2 MPa. sensitive alkaline environments deprotonation LA. released H+ instantly adjust pH weakly seawater-immersed normal deprotonated LA is exert anti-inflammatory functions. Together antibacterial property, applied provide stable barrier protection correct adverse microenvironment, promoting wound healing.

Язык: Английский

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Metal-based antimicrobial agents in wound Dressings: Infection management and the challenge of antibiotic resistance

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160726 - 160726

Опубликована: Фев. 1, 2025

Язык: Английский

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Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 9, 2025

Despite the availability of a series classical antibiotic drugs, bacterial infections continue to represent significant and urgent threat global human health. The emergence drug-resistant bacteria slow pace development have rendered current treatment methods inadequate in meeting clinical demands infections. Consequently, there is an increasingly vital need for safe, efficient, alternative novel antimicrobial agents medical healthcare field. Over past five years, has been notable expansion field nanomedicine with regard prevention control infectious diseases. objective this article provide comprehensive review latest research developments metal nanomaterials therapy. We begin by delineating gravity infection crisis, subsequently undertaking examination potential mechanisms through which nanoparticles may combat specific applications these diverse In conclusion, we eagerly anticipate future directions believe that continuous technological advancements innovations, will make even more outstanding contributions safeguarding health well-being.

Язык: Английский

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Integrated anti-inflammatory and anti-fibrosis dual drug-loaded core-shell fiber scaffolds: Diabetic wound healing and scar reduction

Journal of Material Science and Technology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Thermo-sensitive Poloxamer based antibacterial anti-inflammatory and photothermal conductive multifunctional hydrogel as injectable, in situ curable and adjustable intraocular lens

Bioactive Materials, Год журнала: 2024, Номер 41, С. 30 - 45

Опубликована: Июль 9, 2024

Язык: Английский

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Preparation of ceftiofur-encapsulated hen-egg low-density lipoproteins and their antibacterial effects on intracellular Staphylococcus aureus

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134840 - 134840

Опубликована: Авг. 31, 2024

Язык: Английский

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Metal–Polyphenol–Collagen Self-Assembled Bioadhesive with Immune Regulation for Infected Wound Healing

ACS Applied Polymer Materials, Год журнала: 2024, Номер 6(15), С. 9343 - 9352

Опубликована: Июль 25, 2024

Destroyed skin barriers for extensive cutaneous wounds often bring about delayed healing and even systemic complications. Multifunctional dressing materials targeting different stages of the process have drawn growing concerns to obtain desirable tissue repair. In this study, a self-assembled collagen/tannic acid–zinc (ColTA-Zn) bioadhesive powder with dual cross-linking network was developed infected wound healing. The hydrogen bonds between collagen chains tannic acid, together metal coordination formed by Zn2+ mainly contribute adhesion performances mechanical properties bioadhesive. Furthermore, biocompatible ColTA-Zn exerts antimicrobial effects on Staphylococcus aureus. Crucially, can absorb blood or exudate quickly along rapid gelation adhere surface once contacting wounds, playing roles adsorption, convergence, adhesion. During process, self-gelled exhibits an immunomodulatory effect macrophage polarization ultimately accelerates Therefore, self-assembled, accessible, user-friendly adhesive might be potential candidate dressings adhesive, anti-infectious, conglutinant functions.

Язык: Английский

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