Exosomes in the Chemoresistance of Glioma: Key Point in Chemoresistance
Journal of Cellular and Molecular Medicine,
Год журнала:
2025,
Номер
29(4)
Опубликована: Фев. 1, 2025
ABSTRACT
Gliomas
are
the
most
ordinary
primary
virulent
brain
tumours
and
commonly
used
clinical
treatments
include
tumour
resection,
radiation
therapy
chemotherapy.
Although
significant
progress
has
been
made
in
recent
years
progression‐free
survival
(PFS)
overall
(OS)
for
patients
with
high‐grade
gliomas,
prognosis
remains
poor.
Chemoresistance
refers
to
phenomenon
of
decreased
sensitivity
cells
drugs,
resulting
reduced
or
ineffective
drug
efficacy,
is
an
important
cause
failure
Exosomes,
a
type
extracellular
vesicle,
secreted
by
cancer
various
stromal
microenvironment
(TME)
transfer
their
inclusions
cells,
increasing
chemoresistance.
Furthermore,
depletion
exosomes
reverses
certain
detrimental
effects
on
metabolism
restores
chemotherapeutic
agents.
Here,
we
summarised
correlation
between
resistance
agents
glioma
patients,
mechanisms
action
involved
value.
We
aimed
afford
new
thoughts
research,
diagnosis
intervention
chemoresistance
patients.
Язык: Английский
Exosome-Laden Hydrogels as Promising Carriers for Oral and Bone Tissue Engineering: Insight into Cell-Free Drug Delivery
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11092 - 11092
Опубликована: Окт. 15, 2024
Mineralization
is
a
key
biological
process
that
required
for
the
development
and
repair
of
tissues
such
as
teeth,
bone
cartilage.
Exosomes
(Exo)
are
subset
extracellular
vesicles
(~50–150
nm)
secreted
by
cells
contain
genetic
material,
proteins,
lipids,
nucleic
acids,
other
substances
have
been
extensively
researched
oral
tissue
regeneration.
However,
Exo-free
biomaterials
or
exosome
treatments
exhibit
poor
bioavailability
lack
controlled
release
mechanisms
at
target
site
during
By
encapsulating
Exos
into
like
hydrogels,
these
disadvantages
can
be
mitigated.
Several
engineering
approaches,
those
wound
healing
processes
in
diabetes
mellitus,
treatment
osteoarthritis
(OA)
cartilage
degeneration,
intervertebral
disc
cardiovascular
diseases,
etc.,
exploited
to
deliver
exosomes
containing
variety
therapeutic
diagnostic
cargos
tissues.
Despite
significant
efficacy
Exo-laden
their
use
mineralized
tissues,
tissue,
very
sparse.
This
review
aims
explore
summarize
literature
related
potential
hydrogel-encapsulated
provides
insight
practical
procedures
future
clinical
techniques.
Язык: Английский
Polydopamine-functionalized nanohydroxyapatite coated exosomes with enhanced cytocompatibility and osteogenesis for bone regeneration
Bio-Medical Materials and Engineering,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Background
Mesenchymal
stem
cells-derived
exosomes,
crucial
in
regenerative
medicine,
have
been
explored
for
their
potential
the
functional
modification
of
bone
scaffolds.
Objective
To
design
a
functionally
modified
biomimetic
nanohydroxyapatite
using
exosomes
and
explore
its
effects
on
regeneration.
Methods
A
(named
as
tHA)
was
fabricated
previous
methods
polydopamine
(pDA)
structure
template,
(Exo)
derived
from
periodontal
ligament
cells
(PDLSCs)
were
used
to
modify
tHA
scaffold
material
through
pDA.
The
composite
(tHA-Exo)
proliferation
osteogenic
differentiation
investigated.
Furthermore,
effect
regeneration
also
evaluated
vivo.
Results
Exosomes
can
be
loaded
onto
via
pDA
tHA-Exo
releases
sustained
stable
manner.
showed
improved
cytocompatibility
compared
controls.
Additionally,
significantly
enhanced
PDLSCs.
More
importantly,
animal
experiments
shown
that
could
dramatically
promote
Conclusion
nanoparticles,
by
PDLSCs-Exo
pDA,
promoted
improving
potential,
which
serve
promising
promoting
Язык: Английский