Nanotechnology in the life sciences, Год журнала: 2024, Номер unknown, С. 303 - 368
Опубликована: Янв. 1, 2024
Язык: Английский
Indian Journal of Clinical Biochemistry, Год журнала: 2024, Номер 40(2), С. 191 - 200
Опубликована: Март 15, 2024
Язык: Английский
Процитировано
3
Life Sciences, Год журнала: 2024, Номер 356, С. 122989 - 122989
Опубликована: Авг. 27, 2024
Язык: Английский
Процитировано
3
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Июль 25, 2024
The development of nanovaccines capable eliciting tumor-specific immune responses holds significant promise for tumor immunotherapy. However, many nanovaccine designs rely heavily on incorporating multiple adjuvants and carriers, increasing the biological hazards associated with these additional components. Here, this work introduces novel flexible nanocapsules (OVAnano) designed to mimic extracellular vesicles, primarily using ovalbumin antigen minimal polyethylenimine adjuvant These results show that biomimetic structure OVAnano facilitates enhanced uptake by dendritic cells (DCs), leading efficient release into cytosol via endosomal escape, ultimately, successful cross-presentation DCs. Furthermore, modulates intracellular nuclear factor kappa-B (NF-κB) signaling pathway, promoting DC maturation. highly purified antigens in demonstrate remarkable antigen-specific immunogenicity, triggering strong antitumor mediated Therapeutic vaccination studies have also shown administration effectively suppresses growth mice inducing from CD8
Язык: Английский
Процитировано
2
Biomaterials, Год журнала: 2024, Номер 314, С. 122856 - 122856
Опубликована: Сен. 28, 2024
Язык: Английский
Процитировано
2
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 23, 2024
Achieving full eradication of residual tumors post photothermal therapy (PTT) hinges on the immune system's activation and response. Nevertheless, resultant local inflammation attracts a significant influx aberrant cells fibroblasts, such as tumor-associated macrophages (TAMs) cancer-associated fibroblasts (CAFs), following tumor PTT. This phenomenon exacerbates evasion persistence cells, culminating in recurrence advancement. To tackle this challenge, combined therapeutic approach utilizing multifunctional ICG-SB@Lip-ZA nanosystem has been introduced. Indocyanine green (ICG) photothermal-transducer ablated zoledronic acid (ZA) depletes TAMs recruited by inflammatory microenvironment (mostly M2-like phenotype), SB-505124 affects CAFs proliferation (TME) inhibiting transforming growth factor-β （TGF-β） pathway, thereby removing physical barriers to T cell infiltration. In breast cancer model, these immunomodulatory nanoliposomes markedly decrease population TME, eliminate hindering infiltration, reshape immune-suppressive microenvironment, eventually leading rate 94%. (including conversion, TAM depletion, TGF-β pathway blockade) offers promising strategy for mitigating deteriorating PTT presents more efficient clinical photothermal-immune combination therapy.
Язык: Английский
Процитировано
2
Pharmaceutics, Год журнала: 2024, Номер 16(12), С. 1549 - 1549
Опубликована: Дек. 3, 2024
Nanodrug delivery systems have revolutionized tumor therapy like never before. By overcoming the complexity of microenvironment (TME) and bypassing drug resistance mechanisms, nanotechnology has shown great potential to improve efficacy reduce toxic side effects. This review examines impact TME on recent advances in nanomedicine overcome this challenge. Characteristics such as hypoxia, acidity, high interstitial pressure significantly effectiveness chemotherapy radiotherapy, leading increased cells. Then, summarizes innovative nanocarrier designs for these microenvironmental features, including hypoxia-sensitive nanoparticles, pH-responsive carriers, multifunctional nanosystems that enable targeted release improved penetration accumulation tumors. combining with therapeutic strategies, offers a novel perspective by focusing design nanocarriers interact TME, dimension often overlooked similar reviews. We highlight dual role modulation, emphasize their resistance, look at future research directions.
Язык: Английский
Процитировано
2
Meditsinskaya sestra, Год журнала: 2024, Номер unknown, С. 49 - 53
Опубликована: Окт. 16, 2024
Personalized nanomedicine is a revolutionary direction in healthcare, combining the achievements of nanotechnology with principles an individualized approach to treatment. This study analyzes current state and prospects for development nanomedicine, including use AI management nanorobots neural interfaces. Special attention paid ethical legal aspects safety medicine. Based on comprehensive analysis, recommendations are proposed overcoming technological, regulatory challenges ensure safe effective implementation clinical practice
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 3, 2024
Colorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, a novel therapeutic methodology, opened up new possibilities for colorectal patients. However, its actual clinical efficacy requires further enhancement. Copper, an exceptionally crucial trace element, can influence various signaling pathways, gene expression, and biological metabolic processes in cells, thus playing critical role pathogenesis cancer. Recent studies have revealed that cuproptosis, mode cell death, holds promise to become potential target overcome resistance immunotherapy. This shows substantial combination treatment Conveying copper into tumor cells via nano-drug delivery system induce cuproptosis could offer strategy eliminating drug-resistant vastly improving immunotherapy while ultimately destroy tumors. Moreover, combining induction with other anti-tumor approaches such photothermal therapy, photodynamic chemodynamic therapy enhance effect. review aims illuminate practical significance cuproptosis-inducing nano-drugs immunotherapy, scrutinize current challenges limitations this thereby providing innovative thoughts references advancement cuproptosis-based strategies.
Язык: Английский
Процитировано
1
Microbial Pathogenesis, Год журнала: 2024, Номер 197, С. 107063 - 107063
Опубликована: Окт. 21, 2024
Язык: Английский
Процитировано
0
Advances in chemical and materials engineering book series, Год журнала: 2024, Номер unknown, С. 413 - 440
Опубликована: Окт. 22, 2024
In the field of cancer research, nanotechnology holds tremendous potential for improving therapy efficacy while maintaining treatment safety and opening up new avenues development targeted customized medications. Numerous uses nanomaterials have been reported in therapy, including gene drug resistance, immunotherapy, tumor microenvironment modification, imaging, diagnostics, vaccine administration. To guarantee that medications are delivered precisely to cells, effective delivery systems (TDDS) rely on a number techniques, stimuli-responsive targeting, passive targeting active targeting. leading-edge methods being developed nano pharmaceuticals, which emerged as promising option cancer. fully achieve its promise, obstacles toxicity biocompatibility, manufacturing scalability, regulatory approval still need be addressed.
Язык: Английский
Процитировано
0