Exercise-augmented THSD7B exhibited a positive prognostic implication and tumor-suppressed functionality in pan-cancer
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 5, 2024
Breast
cancer,
one
of
the
most
prevalent
malignancies
among
women
worldwide,
has
rising
incidence
rates.
Physical
activity,
particularly
exercise,
emerged
as
a
significant
modifier
cancer
prognosis,
influencing
both
tumor
biology
and
patient
outcomes.
Язык: Английский
Novel therapeutic insights into pathological cardiac hypertrophy: tRF-16-R29P4PE regulates PACE4 and metabolic pathways
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research,
Год журнала:
2025,
Номер
unknown, С. 119920 - 119920
Опубликована: Фев. 1, 2025
Язык: Английский
Zn‐DHM Nanozymes Enhance Muscle Regeneration Through ROS Scavenging and Macrophage Polarization in Volumetric Muscle Loss Revealed by Single‐Cell Profiling
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Abstract
Volumetric
muscle
loss
(VML)
is
a
severe
condition
in
which
the
of
skeletal
surpasses
body's
intrinsic
repair
capabilities,
leading
to
irreversible
functional
deficits
and
potential
disability,
with
persistent
inflammation
impaired
myogenic
differentiation.
To
address
these
challenges,
novel
zinc‐dihydromyricetin
(Zn‐DHM)
nanozyme
superoxide
dismutase
(SOD)‐like
activity
developed,
designed
neutralize
excessive
reactive
oxygen
species
(ROS)
restore
oxidative
balance.
Zn‐DHM
mitigates
stress
promotes
polarization
macrophages
from
proinflammatory
M1
phenotype
anti‐inflammatory
M2
phenotype,
thereby
reducing
chronic
creating
conducive
environment
for
repair.
Further,
significantly
enhances
differentiation
C
2
12
cells,
accelerating
wound
healing
processes.
These
studies
confirm
biosafety
low
toxicity
Zn‐DHM.
As
per
murine
tibialis
anterior
VML
model,
effectively
suppresses
markedly
improves
outcomes.
Single‐cell
RNA
sequencing
reveals
that
treatment
increases
expression
macrophage
markers
proliferation
capacity
stem
cells
(MuSCs).
In
addition,
intercellular
communication
analysis
interactions
between
MuSCs
group,
suggesting
may
drive
tissue
regeneration
through
activation
GAS
Notch
signaling
pathways.
Язык: Английский
Platelet-rich plasma Inhibits Ferroptosis and Inflammation to Alleviate Frozen Shoulder via Activating the CST1/GPX4 Signaling Pathway
Archives of Biochemistry and Biophysics,
Год журнала:
2025,
Номер
unknown, С. 110429 - 110429
Опубликована: Апрель 1, 2025
Язык: Английский
The impact of diabetes mellitus on tendon pathology: a review
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 5, 2024
Diabetes
is
one
of
the
most
common
metabolic
diseases
worldwide,
leading
to
complications,
mortality,
and
significant
healthcare
expenditures,
which
impose
a
substantial
social
financial
burden
globally.
A
diabetic
environment
can
induce
changes,
negatively
affecting
tendon
homeostasis,
alterations
in
biomechanical
properties
histopathology.
Numerous
studies
have
investigated
mechanisms
through
diabetes
exerts
pathological
effects
on
tendons,
including
increased
free
radical
production,
oxidative
stress,
inflammatory
responses,
deposition
advanced
glycation
end
products
(AGEs),
microvascular
changes.
These
changes
damages
structure,
biomechanics,
repair
processes.
The
proliferation
stem
cells
decreases,
apoptosis
increases,
abnormal
differentiation,
along
with
expression
myofibroblasts,
ultimately
lead
insufficient
repair,
fibrosis,
remodeling.
Although
researches
unveiling
tendinopathy,
fibrosis
or
contracture,
injury
healing
are
growing,
systematic
understanding
still
lacking.
Therefore,
this
review
summarizes
current
research
status
provides
comprehensive
overview,
offering
theoretical
guidance
for
future
in-depth
exploration
impact
tendons
development
treatments
diabetes-related
diseases.
Язык: Английский