Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Дек. 6, 2024

Neuropathic pain (NP) is an ineffectively treated, debilitating chronic disorder that associated with maladaptive changes in the central nervous system, particularly spinal cord. Murine models of NP looking at mechanisms underlying these suggest important role microglia, resident immune cells various stages disease progression. However, given number different and resource limitations come tracking longitudinal animals, many studies fail to truly recapitulate patterns exist between conditions temporal microglial changes. This review integrates how are being carried out murine microglia over time can affect behavior order inform better study design highlight knowledge gaps field. 258 peer-reviewed, primary source articles were selected using Covidence. Trends type mice, statistical tests, models, interventions, markers recorded analyzed. Studies primarily conducted inbred, young adult, male mice having peripheral nerve injury which highlights lack generalizability data currently collected. Changes behavior, both increased, tested most commonly up 2 weeks after initiation despite aberrant activity also later points conditions. treatments decrease show decreased 1- 2-week point not recording involvement dysfunction their development. These results need for only studying dynamics a variety longer but clinically relevant considerations.

Язык: Английский