Advances in cancer immunotherapy: historical perspectives, current developments, and future directions
Mei‐Yin Zhang,
Chao-jun Liu,
Jing Tu
и другие.
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Май 7, 2025
Cancer
immunotherapy,
encompassing
both
experimental
and
standard-of-care
therapies,
has
emerged
as
a
promising
approach
to
harnessing
the
immune
system
for
tumor
suppression.
Experimental
strategies,
including
novel
immunotherapies
preclinical
models,
are
actively
being
explored,
while
established
treatments,
such
checkpoint
inhibitors
(ICIs),
widely
implemented
in
clinical
settings.
This
comprehensive
review
examines
historical
evolution,
underlying
mechanisms,
diverse
strategies
of
cancer
highlighting
its
applications
ongoing
advancements.
The
delves
into
essential
components
anticancer
immunity,
dendritic
cell
activation,
T
priming,
surveillance,
addressing
challenges
posed
by
evasion
mechanisms.
Key
immunotherapeutic
vaccines,
oncolytic
viruses,
adoptive
transfer,
ICIs,
discussed
detail.
Additionally,
role
nanotechnology,
cytokines,
chemokines,
adjuvants
enhancing
precision
efficacy
were
explored.
Combination
particularly
those
integrating
immunotherapy
with
radiotherapy
or
chemotherapy,
exhibit
synergistic
potential
but
necessitate
careful
management
reduce
side
effects.
Emerging
factors
influencing
outcomes,
heterogeneity,
gut
microbiota
composition,
genomic
epigenetic
modifications,
also
examined.
Furthermore,
molecular
mechanisms
therapeutic
resistance
analyzed,
focus
on
contributions
noncoding
RNAs
alterations,
along
innovative
intervention
strategies.
emphasizes
recent
advancements,
particular
attention
biomarker-driven
approaches
aimed
at
optimizing
patient
prognosis.
Challenges
immunotherapy-related
toxicity,
limited
solid
tumors,
production
constraints
highlighted
critical
areas
future
research.
Advancements
personalized
therapies
delivery
systems
proposed
avenues
enhance
treatment
effectiveness
accessibility.
By
incorporating
insights
from
multiple
disciplines,
this
aims
deepen
understanding
application
ultimately
fostering
more
effective
accessible
solutions.
Язык: Английский
Organic small molecule for malignant tumor photothermal / photodynamic and immunotherapy via apoptosis and ferroptosis
European Polymer Journal,
Год журнала:
2025,
Номер
unknown, С. 114018 - 114018
Опубликована: Май 1, 2025
Язык: Английский
Nanomaterials evoke pyroptosis boosting cancer immunotherapy
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
15(2), С. 852 - 875
Опубликована: Ноя. 23, 2024
Cancer
immunotherapy
is
currently
a
very
promising
therapeutic
strategy
for
treating
tumors.
However,
its
effectiveness
restricted
by
insufficient
antigenicity
and
an
immunosuppressive
tumor
microenvironment
(ITME).
Pyroptosis,
unique
form
of
programmed
cell
death
(PCD),
causes
cells
to
swell
rupture,
releasing
pro-inflammatory
factors
that
can
enhance
immunogenicity
remodel
the
ITME.
Nanomaterials,
with
their
distinct
advantages
different
techniques,
are
increasingly
popular,
nanomaterial-based
delivery
systems
demonstrate
significant
potential
potentiate,
enable,
augment
pyroptosis.
This
review
summarizes
discusses
emerging
field
nanomaterials-induced
pyroptosis,
focusing
on
mechanisms
pyroptosis
pathways
strategies
activate
or
specific
Additionally,
we
provide
perspectives
development
this
field,
aiming
accelerate
further
clinical
transition.
Язык: Английский
Recent Developments in Photothermal Therapy: A Bibliometric and Visual Analysis
Опубликована: Янв. 1, 2024
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Язык: Английский
Recent developments in photothermal therapy: a bibliometric and visual analysis
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
unknown, С. 1 - 21
Опубликована: Дек. 8, 2024
Photothermal
therapy
(PTT)
has
recently
garnered
significant
attention
as
a
prominent
noninvasive
treatment
modality
for
broad
spectrum
of
diseases.
Despite
the
increasing
volume
scholarly
output
over
last
20
years,
holistic
synthesis
that
delineates
worldwide
research
trajectories
remains
elusive.
We
undertook
bibliometric
analysis
literature
from
2004
to
2023,
aiming
delineate
prevailing
focal
points
and
illuminate
prospective
avenues.
Research
articles
on
PTT
were
retrieved
Web
Science
Core
Collection.
Using
tools
such
CiteSpace,
VOSviewer,
Bibliometrix,
we
comprehensively
analyzed
visualized
11,184
published
academic
papers.
China
highest
number
publications.
Journals
related
are
primarily
comprised
interdisciplinary
comprehensive
journals.
associated
with
focused
its
antitumor
properties.
Current
areas
in
this
domain
include
synergistic
combination
photodynamic
therapy,
immunological
mechanisms
enhance
therapeutic
efficacy,
integrated
use
nanoenzyme
catalysis,
role
antimicrobial
applications.
This
provides
an
initial
examination
medical
applications
PTT,
offering
insights
into
global
landscape,
key
interest,
emerging
trends,
thereby
serving
valuable
reference
future
studies
field.
Язык: Английский