Cancer stem cells: advances in knowledge and implications for cancer therapy
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 5, 2024
Abstract
Cancer
stem
cells
(CSCs),
a
small
subset
of
in
tumors
that
are
characterized
by
self-renewal
and
continuous
proliferation,
lead
to
tumorigenesis,
metastasis,
maintain
tumor
heterogeneity.
continues
be
significant
global
disease
burden.
In
the
past,
surgery,
radiotherapy,
chemotherapy
were
main
cancer
treatments.
The
technology
treatments
develop
advance,
emergence
targeted
therapy,
immunotherapy
provides
more
options
for
patients
certain
extent.
However,
limitations
efficacy
treatment
resistance
still
inevitable.
Our
review
begins
with
brief
introduction
historical
discoveries,
original
hypotheses,
pathways
regulate
CSCs,
such
as
WNT/β-Catenin,
hedgehog,
Notch,
NF-κB,
JAK/STAT,
TGF-β,
PI3K/AKT,
PPAR
pathway,
their
crosstalk.
We
focus
on
role
CSCs
various
therapeutic
outcomes
resistance,
including
how
affect
content
alteration
related
molecules,
CSCs-mediated
clinical
value
targeting
refractory,
progressed
or
advanced
tumors.
summary,
efficacy,
method
is
difficult
determine.
Clarifying
regulatory
mechanisms
biomarkers
currently
mainstream
idea.
Язык: Английский
Targeting Cancer Stemness Using Nanotechnology in a Holistic Approach: A Narrative Review
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 277 - 277
Опубликована: Фев. 20, 2025
Increasing
evidence
shows
that
a
very
small
population
of
cancer
stem
cells
(CSCs)
is
responsible
for
recurrence,
drug
resistance,
and
metastasis.
CSCs
usually
reside
in
hypoxic
tumor
regions
are
characterized
by
high
tumorigenicity.
Their
inaccessible
nature
allows
them
to
avoid
the
effects
conventional
treatments
such
as
chemotherapy,
radiotherapy,
surgery.
In
addition,
chemo-
radiotherapy
potentially
toxic
could
help
spread
survive.
New
therapeutic
targets
against
sought,
including
different
signaling
pathways
distinct
cell
surface
markers.
Recent
advances
nanotechnology
have
provided
hope
development
new
avenues
eradicate
CSCs.
this
review,
we
present
newly
discovered
nanoparticles
can
be
co-loaded
with
an
apoptosis-inducing
agent
or
differentiation-inducing
agent,
stability,
cellular
penetration,
release.
We
also
summarize
molecular
characteristics
their
survival
maintenance.
Controlled
release
targeting
aims
reduce
stemness-related
suppress
growth,
prevent
relapse
metastases.
Язык: Английский
Detection of Cancer Stem Cells from Patient Samples
Cells,
Год журнала:
2025,
Номер
14(2), С. 148 - 148
Опубликована: Янв. 20, 2025
The
existence
of
cancer
stem
cells
(CSCs)
in
various
tumors
has
become
increasingly
clear
addition
to
their
prominent
role
therapy
resistance,
metastasis,
and
recurrence.
For
early
diagnosis,
disease
progression
monitoring,
targeting,
there
is
a
high
demand
for
clinical-grade
methods
quantitative
measurement
CSCs
from
patient
samples.
Despite
years
active
research,
standard
not
yet
reached
clinical
settings,
especially
the
case
solid
tumors.
This
because
detecting
this
plastic
heterogeneous
population
straightforward.
review
summarizes
techniques,
highlighting
benefits
limitations
In
addition,
designed
detect
based
on
secreted
niche-associated
signaling
factors
are
reviewed.
Spatial
single-cell
analyzing
tumor
tissues
noninvasive
techniques
such
as
liquid
biopsy
vivo
imaging
discussed.
Additionally,
recently
established
laboratories,
preclinical
studies,
assays
covered.
Finally,
we
discuss
characteristics
an
ideal
method
look
toward
future.
Язык: Английский
Emerging roles of hyaluronic acid hydrogels in cancer treatment and wound healing: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140442 - 140442
Опубликована: Янв. 1, 2025
Язык: Английский
Recent advances in DNA nanotechnology for cancer detection and therapy: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142136 - 142136
Опубликована: Март 1, 2025
Язык: Английский
Mapping global research in the field of health biotechnology for the period 1990–2023. A bibliometric analysis
Journal of Science and Technology Policy Management,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 16, 2024
Purpose
The
purpose
of
this
study
focused
on
a
global
longitudinal
bibliometric
mapping
research
in
the
field
health
biotechnology
between
1990
and
2023
to
determine
who
is
leading
knowledge
estimate
sub-disciplines
that
are
emerging
project
those
will
prevail
future.
Design/methodology/approach
identified
most
relevant
countries,
institutions
researchers,
as
well
type
scientific
collaborations.
applied
steps
were
following:
identification
selection
keyword
terms
by
panel
experts;
design
application
an
algorithm
identify
these
selected
keywords
titles,
abstracts
using
Web
Science
contrast
them;
performance
JCR
data
processing
during
R,
Python
VOSviewer.
Findings
Among
conclusions
following
exponential
growth
has
been
observed
period;
new
branches
have
emerged
which
subjects
acquiring
their
own
autonomous
capabilities;
R&D
still
concentrated
small
group
core
trend
for
it
remain
so
due
capacity
needs
required.
Originality/value
This
contribution
seeks
systematize
existing
biotechnology,
specifically
area
health,
technique
based
logical
model
indicators
aims
potential
thematic
ramifications.
Язык: Английский
DLK1 Is Associated with Stemness Phenotype in Medullary Thyroid Carcinoma Cell Lines
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 11924 - 11924
Опубликована: Ноя. 6, 2024
Medullary
thyroid
carcinoma
(MTC)
is
a
rare
and
aggressive
tumor,
often
requiring
systemic
treatment
in
advanced
or
metastatic
stages,
where
drug
resistance
presents
significant
challenge.
Given
the
role
of
cancer
stem
cells
(CSCs)
recurrence
resistance,
we
aimed
to
identify
CSC
subpopulations
within
two
MTC
cell
lines
harboring
pathogenic
variants
most
common
MEN2-associated
codons.
We
analyzed
15
stemness-associated
markers,
along
with
well-established
markers
(CD133,
CD44,
ALDH1),
novel
candidate
(DLK1),
multidrug
proteins
(MRP1
MRP3).
The
ability
efflux
fluorescent
dye
Hoechst
3342
form
spheroids,
representing
behavior,
was
also
assessed.
MZ-CRC-1
(p.M918T)
displayed
higher
expressions
canonical
DLK1,
MRP
than
TT
(p.C634W).
formed
more
spheroids
showed
less
accumulation
(p
<
0.0001).
Finally,
observed
that
DLK1+
(those
expressing
DLK1)
both
exhibited
significantly
levels
stemness
compared
DLK1−
lacking
DLK1
expression).
These
findings
underscore
DLK1’s
enhancing
phenotype,
providing
valuable
insights
into
progression
suggesting
potential
therapeutic
implications.
Язык: Английский
Crosstalk between thyroid CSCs and immune cells: basic principles and clinical implications
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 24, 2024
Thyroid
cancer
has
become
the
most
common
endocrine
malignancy.
Although
majority
of
differentiated
thyroid
cancers
have
a
favorable
prognosis,
advanced
cancers,
iodine-refractory
and
highly
malignant
undifferentiated
carcinomas
still
face
serious
challenge
poor
prognosis
even
death.
Cancer
stem
cells
are
recognized
as
one
central
drivers
tumor
evolution,
recurrence
treatment
resistance.
A
fresh
viewpoint
on
oncological
aspects
cancer,
including
proliferation,
invasion,
recurrence,
metastasis,
therapeutic
resistance,
been
made
possible
by
recent
thorough
understanding
defining
developing
features
well
plasticity
(TCSCs).
The
above
characteristics
TCSCs
complicated
regulated
cell-intrinsic
mechanisms
(including
activation
key
signaling
pathways,
somatic
cell
dedifferentiation,
etc.)
cell-extrinsic
mechanisms.
complex
communication
between
infiltrating
immune
populations
in
microenvironment
(TME)
is
paradigm
for
regulators.
This
review
introduces
current
advances
studies
TCSCs,
origin
intrinsic
pathways
regulating
stemness
emerging
biomarkers;
We
further
highlight
underlying
principles
bidirectional
crosstalk
driving
progression,
or
specific
which
maintain
other
properties
how
reshape
microenvironmental
landscape
to
create
an
evasive
pro-tumorigenic
ecological
niche.
Finally,
we
outline
promising
strategies
challenges
targeting
programs
TCSCs-immune
process
treat
cancer.
Язык: Английский