Gasdermin E as a potential target and biomarker for CRISPR-Cas9-based cancer therapy DOI
Mojtaba Tarin, Amir Sh. Saljooghi

Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116961 - 116961

Опубликована: Апрель 1, 2025

Язык: Английский

Convertible ROS Nanogenerator/Eliminator for Enhanced Tumor Photothermal Therapy with Reduced Inflammatory Response DOI Open Access

Houren Zhou,

Xinyu Zhang, Hui Liu

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract Photothermal therapy (PTT), as an innovative optical tumor treatment strategy, is characterized by its minimal invasiveness, high selectivity, long‐lasting efficacy, and safety, has attracted widespread attention. However, in order to effectively kill cancer cells, a higher local temperature very necessary, which inevitably results severe stress responses cell death, thereby triggering harmful inflammation. Additionally, achieving effective controlled release of drugs the microenvironment reduce systemic side effects still major challenge. Herein, intelligent nanoplatform first reported, featured sulfide iron (FeS) nanosheets core, loaded with perfluorohexane (PFH), skillfully coated polydopamine (PDA). It can serve generator reactive oxygen species (ROS) induce ferroptosis, further intensifying PTT, ROS eliminator normal tissue control undesired inflammatory response during differential strategy between surrounding tissue. Meanwhile, combination ultrasound‐targeted microbubble destruction (UTMD) technology significantly enhanced penetration drug. Overall, delivery FeS/PFH@PDA combined UTMD achieve precise efficient synergistic for tumors demonstrate outstanding ultrasound MR dual‐mode imaging performance.

Язык: Английский

Процитировано

1

Ultrasound-responsive Smart Biomaterials for Bone Tissue Engineering DOI

Bicheng Ake,

Hongsheng Yang, Hao Yang

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Bone defects resulting from trauma, tumors, or other injuries significantly impact human health and quality of life. However, current treatments for bone are constrained by donor shortages immune rejection. tissue engineering has partially alleviated the limitations traditional repair methods. The development smart biomaterials that can respond to external stimuli modulate biofunctions become a prominent area research. Ultrasound technology is regarded as an optimal "remote controller" "trigger" biomaterials. This review reports comprehensive systematic overview ultrasound-responsive It presents fundamental theories repair, definition ultrasound, its applications. Furthermore, summarizes ultrasound effect mechanisms their roles in including detailed studies on anti-inflammation, immunomodulation, cell therapy. Finally, advantages future prospects this field discussed.

Язык: Английский

Процитировано

0

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications DOI Creative Commons
Luyao Tian, Shilong Piao, Xia Li

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Abstract Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, acts double‐edged sword, making it important optimize strategies functional materials appropriately activate effective disease treatment. This paper summarizes discusses structure, pore formation, molecular mechanisms “executor” Gasdermins, well events preceding following these processes. Subsequently, focus is on reviewing that directly regulate Gasdermin formation target those indirectly before after control activity. Finally, advantages, disadvantages, future prospects designing such are provided, aiming facilitate precise design, pharmacological investigation, clinical translation pyroptosis‐related materials.

Язык: Английский

Процитировано

0

Therapeutic Applications of Nanodroplets in Ultrasound: In Vitro and in Vivo Perspectives DOI
Lantian Wang,

Zhaoyou Liu,

Yubo Lai

и другие.

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Язык: Английский

Процитировано

0

Dual-responsive nanoscale ultrasound contrast agent as an oxidative stress amplifier for enhanced DNA damage in BRCA-proficient ovarian cancer DOI Creative Commons

Jialu Zhang,

Xiaoxuan Wang,

Lu Guo

и другие.

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101761 - 101761

Опубликована: Апрель 11, 2025

PARP inhibitor (PARPi)-based synthetic lethal therapies have displayed limited benefits in BRCA-proficient ovarian cancer. To potentiate the application of PARPi, an ultrasound contrast agent OLA-NDs for delivery PARPi olaparib (OLA) was established enhancing DNA damage by blocking repair. were endowed with endogenous pH- and exogenous (US)-responsiveness to target tumors, as well contrast-enhanced US imaging diagnostic therapeutic integration. could upregulate NOX4 induce oxidative stress sensitize BRCA wild-type A2780 cells through utilization ultrasound-targeted microbubble destruction (UTMD). In addition, strategy further increased ROS production interfering mitochondrial function, thereby exacerbating double-strand breaks (DSBs) inducing mitochondria-mediated apoptosis. As a consequence, combined UTMD demonstrated significant antitumor effects vitro vivo. This amplifying improved lethality promoting DSBs apoptosis reduced adverse side effects, which would provide new insight clinical

Язык: Английский

Процитировано

0

Gasdermin E as a potential target and biomarker for CRISPR-Cas9-based cancer therapy DOI
Mojtaba Tarin, Amir Sh. Saljooghi

Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116961 - 116961

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0