Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116961 - 116961
Опубликована: Апрель 1, 2025
Язык: Английский
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Abstract Photothermal therapy (PTT), as an innovative optical tumor treatment strategy, is characterized by its minimal invasiveness, high selectivity, long‐lasting efficacy, and safety, has attracted widespread attention. However, in order to effectively kill cancer cells, a higher local temperature very necessary, which inevitably results severe stress responses cell death, thereby triggering harmful inflammation. Additionally, achieving effective controlled release of drugs the microenvironment reduce systemic side effects still major challenge. Herein, intelligent nanoplatform first reported, featured sulfide iron (FeS) nanosheets core, loaded with perfluorohexane (PFH), skillfully coated polydopamine (PDA). It can serve generator reactive oxygen species (ROS) induce ferroptosis, further intensifying PTT, ROS eliminator normal tissue control undesired inflammatory response during differential strategy between surrounding tissue. Meanwhile, combination ultrasound‐targeted microbubble destruction (UTMD) technology significantly enhanced penetration drug. Overall, delivery FeS/PFH@PDA combined UTMD achieve precise efficient synergistic for tumors demonstrate outstanding ultrasound MR dual‐mode imaging performance.
Язык: Английский
Процитировано
1
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Bone defects resulting from trauma, tumors, or other injuries significantly impact human health and quality of life. However, current treatments for bone are constrained by donor shortages immune rejection. tissue engineering has partially alleviated the limitations traditional repair methods. The development smart biomaterials that can respond to external stimuli modulate biofunctions become a prominent area research. Ultrasound technology is regarded as an optimal "remote controller" "trigger" biomaterials. This review reports comprehensive systematic overview ultrasound-responsive It presents fundamental theories repair, definition ultrasound, its applications. Furthermore, summarizes ultrasound effect mechanisms their roles in including detailed studies on anti-inflammation, immunomodulation, cell therapy. Finally, advantages future prospects this field discussed.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Abstract Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, acts double‐edged sword, making it important optimize strategies functional materials appropriately activate effective disease treatment. This paper summarizes discusses structure, pore formation, molecular mechanisms “executor” Gasdermins, well events preceding following these processes. Subsequently, focus is on reviewing that directly regulate Gasdermin formation target those indirectly before after control activity. Finally, advantages, disadvantages, future prospects designing such are provided, aiming facilitate precise design, pharmacological investigation, clinical translation pyroptosis‐related materials.
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 32, С. 101761 - 101761
Опубликована: Апрель 11, 2025
PARP inhibitor (PARPi)-based synthetic lethal therapies have displayed limited benefits in BRCA-proficient ovarian cancer. To potentiate the application of PARPi, an ultrasound contrast agent OLA-NDs for delivery PARPi olaparib (OLA) was established enhancing DNA damage by blocking repair. were endowed with endogenous pH- and exogenous (US)-responsiveness to target tumors, as well contrast-enhanced US imaging diagnostic therapeutic integration. could upregulate NOX4 induce oxidative stress sensitize BRCA wild-type A2780 cells through utilization ultrasound-targeted microbubble destruction (UTMD). In addition, strategy further increased ROS production interfering mitochondrial function, thereby exacerbating double-strand breaks (DSBs) inducing mitochondria-mediated apoptosis. As a consequence, combined UTMD demonstrated significant antitumor effects vitro vivo. This amplifying improved lethality promoting DSBs apoptosis reduced adverse side effects, which would provide new insight clinical
Язык: Английский
Процитировано
0
Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116961 - 116961
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0