Nanomaterials for Endogenous and Exogenous Hydrogen Sulfide-Based NIR Photothermal Cancer Therapy: A Review DOI

Yucheng Zeng,

Tianyu Wu, Qingshan Pan

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(20), С. 23397 - 23415

Опубликована: Окт. 12, 2024

Hydrogen sulfide (H2S) is recognized as the third gaseous signaling molecule present, playing a crucial role in cellular processes. When designing nanomaterials, H2S not only serves cancer biomarker but also directly influences tumor cell proliferation and metastasis by modulating its concentration. However, gas donor inability to actively accumulate within tumors release controlled manner results restricted treatment efficacy potential toxic side effects. Near-infrared (NIR) responsive photothermal probes are characterized their rapid response time, high selectivity, sensitivity, noninvasive attributes. They offer opportunity for precise, real-time, modulation of concentrations at both murine levels. The integration therapy with other modalities through multifunctional nanocarrier platforms shows promise enhancing outcomes while minimizing adverse development capable controllably properties considered essential yet challenging academic research. This Review critically assesses two primary approaches NIR strategies involving H2S: targeted utilizing combining alternative modalities. Additionally, this addresses current limitations these technologies outlines future directions advancement. Overall, aims provide insights guidance seamless therapy, aligning rigorous standards journals.

Язык: Английский

Tumor microenvironment activation amplify oxidative stress promoting tumor energy remodeling for mild photothermal therapy and cuproptosis DOI Creative Commons

Lihong Qiao,

Wenting Xuan,

Yijing Ou

и другие.

Redox Biology, Год журнала: 2024, Номер 75, С. 103260 - 103260

Опубликована: Июнь 28, 2024

Tumor metabolic reprogramming requires high levels of adenosine triphosphate (ATP) to maintain treatment resistance, which poses major challenges chemotherapy and photothermal therapy. Especially, ATP promote copper ion efflux for limiting the curative effect cuproptosis. Here, an H

Язык: Английский

Процитировано

5
Curcumin-derived water-soluble carbon dots without detectable resistance: Dual potentials for antimicrobial activity and infected wound healing DOI

Jinyan Du,

S.M. Liu,

Jiwei Hou

и другие.

Diamond and Related Materials, Год журнала: 2025, Номер 153, С. 112075 - 112075

Опубликована: Фев. 6, 2025

Язык: Английский

Процитировано

0
Nanomaterials for Endogenous and Exogenous Hydrogen Sulfide-Based NIR Photothermal Cancer Therapy: A Review DOI

Yucheng Zeng,

Tianyu Wu, Qingshan Pan

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(20), С. 23397 - 23415

Опубликована: Окт. 12, 2024

Hydrogen sulfide (H2S) is recognized as the third gaseous signaling molecule present, playing a crucial role in cellular processes. When designing nanomaterials, H2S not only serves cancer biomarker but also directly influences tumor cell proliferation and metastasis by modulating its concentration. However, gas donor inability to actively accumulate within tumors release controlled manner results restricted treatment efficacy potential toxic side effects. Near-infrared (NIR) responsive photothermal probes are characterized their rapid response time, high selectivity, sensitivity, noninvasive attributes. They offer opportunity for precise, real-time, modulation of concentrations at both murine levels. The integration therapy with other modalities through multifunctional nanocarrier platforms shows promise enhancing outcomes while minimizing adverse development capable controllably properties considered essential yet challenging academic research. This Review critically assesses two primary approaches NIR strategies involving H2S: targeted utilizing combining alternative modalities. Additionally, this addresses current limitations these technologies outlines future directions advancement. Overall, aims provide insights guidance seamless therapy, aligning rigorous standards journals.

Язык: Английский

Процитировано

0