FeMo6 integrated covalent organic frameworks: Peroxidase-mimetic colorimetric biosensors for multivariate sensing hydrogen peroxide and ascorbic acid in serum and beverages

Food Chemistry, Год журнала: 2025, Номер 479, С. 143727 - 143727

Опубликована: Март 6, 2025

Язык: Английский

---

A Modified Polydopamine Nanoparticle Loaded with Melatonin for Synergistic ROS Scavenging and Anti‐Inflammatory Effects in the Treatment of Dry Eye Disease

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract Dry eye disease (DED) is a multifaceted ocular surface disorder that significantly impacts patients’ daily lives and imposes substantial economic burden on society. Oxidative stress, induced by the overproduction of reactive oxygen species (ROS), critical factor perpetuating inflammatory cycle in DED. Effectively scavenging ROS essential to impede progression In this study, boronophenylalanine‐ containing polydopamine (PDA‐PBA) nanoparticles are developed loaded with melatonin (MT), which blended poly(vinyl alcohol) (PVA) create drops PVA/ PDA‐PBA@MT (PPP@MT). vitro vivo studies demonstrate PPP@MT exhibits dual functionalities reducing production downregulating pathways, thereby preserving mitochondrial integrity further inhibiting programmed cell death. Following treatment, tear secretion, corneal structure, number goblet cells markedly restored mouse model dry eye, indicating therapeutic efficacy agent. Collectively, PPP@MT, characterized minimal side effects favorable bioavailability, offers promising insights for management DED other ROS‐mediated disorders.

Язык: Английский

---

Fluorinated multifunctional polymer vesicles for enhanced ocular surface penetration and synergistic treatment of dry eye disease

Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 592 - 608

Опубликована: Янв. 24, 2025

Язык: Английский

---

Selenium nanoparticles attenuate retinal pathological angiogenesis by disrupting cell cycle distribution

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Март 21, 2025

This study aims to explore the mechanism by which selenium nanoparticles (SeNPs) inhibit retinal neovascularization (RNV) and identify a more effective treatment for pathological RNV. The characterization identification of synthesized were conducted investigate their effects on function human umbilical vein endothelial cells (HUVECs), blood vessel development in mice, impact oxygen-induced retinopathy. Tritium-labeled thymine was utilized label newly DNA both vivo vitro, allowing observation SeNPs' cell proliferation. Additionally, flow cytometry, immunofluorescence, western blotting techniques employed elucidate mechanisms SeNPs neovascularization. can significantly functions vascular cells, particularly proliferation, vitro. achieve this modulating expression cycle-related proteins through regulation PI3K-AKT-p21 axis, turn inhibits transition cycle from G1 phase S phase. may be novel interference

Язык: Английский

---

Associations between air pollution and daily outpatient visits for dry eye disease and the effect modification of temperature

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Март 27, 2025

Abstract Background Dry eye disease (DED) is one of the most common ocular surface disorders caused by various contributors. Air pollutants are considered a risk factor for diseases. We aimed to investigate associations between air (PM 2.5 , PM 10 NO 2 SO CO and O 3 ) constituents daily outpatient visits DED, as well modifying effect temperature on associations. Methods Daily data DED environmental variables during 2014–2019 were collected in Hangzhou, China. Distributed lag nonlinear models (DLNM) combined with time-stratified case-crossover design utilized evaluate effects 0‒3 days. Furthermore, we also estimated modification stratified median. The attributable fraction (AF) quantified. Stratified analyses gender, age, seasons conducted assess vulnerable population characteristics high-risk periods. Results Every interquartile range increase concentration significantly associated cases. AF 6.42% (95% CI: 1.09%, 11.58%), 8.00% (2.60%, 13.60%), 18.65% (11.52%, 25.21%), 10.82% (3.92%, 17.24%) 12.28% (0.23%, 22.86%), respectively. For constituents, − NH 4 + 4.34% (0.21%, 8.11%) 4.84% (0.18%, 9.09%), pollution significant low-temperature level CO; while statistically insignificant high-temperature level. Subgroup indicated present winter among patients aged 21–40 but other age groups. Conclusion Our results revealed that visits. Low temperatures might hazardous pollution. Besides, individuals pollution, was period. Clinical trial number Not applicable. Graphical abstract

Язык: Английский

---

Ruthenium Nanozyme@Magnesium silicate nanosheets encapsuled in microneedle patches promote repair of radiation‐induced skin defects by remodeling pathological environment

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Abstract Radiotherapy induced skin defect (RISD) is a severe radiotherapy complication with persistent oxidative stress and recurrent excessive reactive oxygen species (ROS), impeding normal tissue repair processes. Nevertheless, the lack of standardized animal model severely hinders progress related research work. We develop novel strategy for repairing RISD microenvironment, which combines initial ROS clearance, subsequent inhibition production proliferation cell pathways/functions. As proof concept, composite microneedle (MN) patch comprising γ‐polyglutamic acid as base ruthenium (Ru) clusters modified magnesium silicate nanosheets (MSR NSs) enzyme‐like component prepared. The Ru have excellent scavenging ability help activate peroxisome proliferators activated receptor signaling pathway confirmed by sequencing analysis while degraded under physiological conditions to release ions ions, enhancing proliferation, migration, angiogenesis ability. radiation established evaluate efficacy our MSR@MN in comparison γPGA‐MSR ointment commercial product Orgotein. results show that effectively improves pathological microenvironment abnormal accumulation, reduces inflammatory response promotes mature remodeling.

Язык: Английский

---

Advances in the application of smart materials in the treatment of ophthalmic diseases

Biomaterials, Год журнала: 2025, Номер unknown, С. 123316 - 123316

Опубликована: Апрель 1, 2025

Язык: Английский

---

TRPV1-targeted ion-responsive hydrogel against pyroptosis of dry eye disease

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156155 - 156155

Опубликована: Сен. 1, 2024

Язык: Английский

---

Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Abstract The incidence of dry eye disease (DED) has been increasing annually worldwide, creating an urgent need for new therapies. Due to the multifactorial mechanism underlying DED, traditional medications focused on decreasing ocular surface inflammation have unable address all harmful factors and fail achieve a complete clinical cure. Ferroptosis, form programmed cell death characterized by lipid peroxidation, become pivotal contributor oxidative stress‐driven pathology. Therefore, therapeutic targeting ferroptosis may be attractive option management. Herein, sialic acid‐targeting peptide‐modified liposome loaded with Cyclosporine A (CsA), typical anti‐inflammatory drug, Ferrostatin‐1 (Fer‐1), selective inhibitor, is developed termed as CF@SNPs, combing sustaining DED treatment. This multifunctional liposomal encapsulation demonstrates excellent aqueous solubility; moreover, peptide prolongs retention, further enhancing efficacy. CF@SNPs treatment comprehensively alleviates symptoms, including improving corneal defects, augmenting goblet count, restoring tear secretion. Specifically, attenuate pathology suppressing p53‐SLC7A11‐GSH‐dependent TNF‐α‐associated inflammatory cascades, accompanied favorable biocompatibility in vivo. These results underscore promising potential this superior nano‐formulation pharmacotherapy.

Язык: Английский

---

Borate and Disulfide Dual‐Dynamic Hydrogel for ROS Dual‐Scavenging

Journal of Polymer Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 30, 2024

ABSTRACT The excessive accumulation of reactive oxygen species (ROS) on wound surfaces poses considerable challenges to the healing process, as it exacerbates inflammation and heightens risk skin infections. Consequently, development multifunctional dressings that possess both ROS‐scavenging antimicrobial properties is clinical significance for enhancing healing. To address these challenges, we synthesized a dual‐scavenging hydrogel utilizing dual‐dynamic crosslinking techniques. This composed poly‐lysine‐grafted D‐glucono‐1,5‐lactone, dithiodipropionic acid/lipoic acid, dopamine (PLGDTD), in conjunction with borax. attributes can be attributed incorporation borate esters, dopamine, disulfide bonds. Experimental results demonstrate this exhibits robust antioxidant capacity pronounced inhibitory effect against Staphylococcus aureus Escherichia coli . cellular studies indicate capable effectively scavenging ROS mitigating oxidative stress, attributable its mechanism involving demonstrates significant potential candidate associated ROS.

Язык: Английский

---