Evaluation of Ocular and Systemic Oxidative Stress Markers in Patients with Diabetic Retinopathy

Life, Год журнала: 2024, Номер 14(12), С. 1588 - 1588

Опубликована: Дек. 2, 2024

Proliferative diabetic retinopathy (PDR) is the most severe complication of chronic hyperglycaemi stimulates oxidative stress that changes retinal basement membrane function and provokes neovascularization, macular edema detachment. But an oxidative–antioxidant biomarker assessment in ocular matrices, such as aqueous humor (AH) vitreous, might show (OS) status posterior segment. Here, we a cross-sectional analytical study 39 patients who had vitrectomy assess levels different biomarkers blood, vitreous three groups: diabetes mellitus 2 (DM2) with PDR [DM(+)PDR(+)] (n =13), DM2 without [DM(+)PDR(−)] = 13) non-DM2 non-PDR [DM(−)PDR(−)] control group 13). Our finding suggests presence retinopathy, evidenced by increased 8-isoprostanes decreased total antioxidant capacity from stages before development retinopathy. results reveal notable increment catalase DM(+)PDR(+) blood humor. Likewise, identified DM(+)PDR(−) presents significant 8-IP SOD versus These suggest role enzymes compensating mechanisms development.

Язык: Английский

3D Printing of Stiff, Tough, and ROS-Scavenging Nanocomposite Hydrogel Scaffold for in Situ Corneal Repair

Acta Biomaterialia, Год журнала: 2024, Номер 192, С. 189 - 205

Опубликована: Дек. 4, 2024

Язык: Английский

Hyaluronan-modified nanoceria for dry eye disease treatment

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 215 - 225

Опубликована: Дек. 25, 2024

Язык: Английский