Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review DOI

Mohammad Ebrahim Astaneh,

Narges Fereydouni

International Journal of Polymeric Materials, Год журнала: 2024, Номер unknown, С. 1 - 33

Опубликована: Дек. 16, 2024

This review delves into the efficacy of electrospun nanofibers as structures capable neutralizing Reactive Oxygen Species (ROS), thereby aiding in acceleration wound repair. ROS occupy a dual position cellular dynamics, being indispensable for intracellular communication, yet they potentially exacerbate oxidative stress which can stall healing trajectory. The method electrospinning synthesizes distinguished by their expansive surface area relative to volume and notable porosity, rendering them optimally suited medical endeavors, particularly frameworks that bolster recuperation. analysis elucidates diverse roles these play, from enhancing clot formation combating microbial invasion mitigating inflammation, fostering proliferation, facilitating angiogenesis—each pivotal component effective mending wounds.

Язык: Английский

Multifunctional nanoparticles for image-guided drug delivery in nuclear medicine: advancements and applications DOI

Bilal AbdulMajeed Mukhlif,

Muhammad Ikram Ullah, Subasini Uthirapathy

и другие.

Journal of Radioanalytical and Nuclear Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Язык: Английский

Процитировано

2
Neuron Modulation by Synergetic Management of Redox Status and Oxidative Stress DOI Open Access
Xianping Liu, Xingwu Jiang, Zonghao Liu

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Abstract The transient receptor potential (TRP) channel is a key sensor for diverse cellular stimuli, regulating the excitability of primary nociceptive neurons. Sensitization TRP can heighten pain sensitivity to innocuous or mildly noxious stimuli. Here, reversible modulation channels achieved by controlling both light‐induced photoelectrochemical reaction induce neuronal depolarization, and antioxidants protection. It based on hybrid nanosystem, CZPN, created coating CeO 2 nanocrystals with metalloporphyrin ZnTPyP. Light irradiation triggers an electrochemical response, efficient electron injection from ZnTPyP , converting Ce 4+ into 3+ as antioxidants. Meanwhile, charge migrates surrounding O molecules hole‐injected * giving rise reactive oxygen species (ROS). This change in redox environment sensitizes channels, eliciting action potentials rat neurons, partially blocked pretreatment capsazepine. resulting 2‐x high /Ce ratio, scavenge excessive ROS prevent oxidative damage. behaviors mice pre‐injected CZPN are further confirmed. work suggests safe, effective, universal approach processes research peripheral nervous system.

Язык: Английский

Процитировано

1
Targeted nanomedicine modulating intercellular communications to arrest renal cell carcinoma progression DOI

Mohammad Habeeb,

Shivani Arsey, Huay Woon You

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105983 - 105983

Опубликована: Июль 20, 2024

Процитировано

6
Dual Functionality of Cobalt Oxide Nanoparticles: Exploring Their Potential as Antimicrobial and Anticancer Agents DOI
Ikhazuagbe H. Ifijen,

Emmanuel Faderin,

C. O. OKAFOR

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Язык: Английский

Процитировано

0
An Evaluation of the Potential Radiosensitization Effect of Spherical Gold Nanoparticles to Induce Cellular Damage Using Different Radiation Qualities DOI Creative Commons
Monique Engelbrecht,

Xanthene Miles,

Charlot Vandevoorde

и другие.

Molecules, Год журнала: 2025, Номер 30(5), С. 1038 - 1038

Опубликована: Фев. 24, 2025

Global disparities in cancer prevention, detection, and treatment demand a unified international effort to reduce the disease's burden improve outcomes. Despite advances chemotherapy radiotherapy, many tumors remain resistant these treatments. Gold nanoparticles (AuNPs) have shown promise as radiosensitizers, enhancing effectiveness of low-energy X-rays by emitting Auger electrons that cause localized cellular damage. In this study, spherical AuNPs 5 nm 10 were characterized tested on various cell lines, including malignant breast cells (MCF-7), non-malignant (CHO-K1 MCF-10A), human lymphocytes. Cells treated with irradiated attenuated 6 megavoltage (MV) or p(66)/Be neutron radiation assess DNA double-strand break (DSB) damage, viability, cycle progression. The combination induced higher levels γ-H2AX foci micronucleus formation compared treatments X-ray alone. alone reduced kinetics increased accumulation G2/M phase, suggesting block For proliferation, significant effects only observed at concentration 50 μg/mL AuNPs, while lower concentrations had no inhibitory effect. Further research is needed quantify internalized correlate their unravel biological mechanisms radioenhancement.

Язык: Английский

Процитировано

0
Extraction, Purification and Characterization of Exopolysaccharide from Lactiplantibacillus plantarum B7 with Potential Antioxidant, Antitumor and Anti-Inflammatory Activities DOI Open Access
Abeer A. Ageeli, Sahera F. Mohamed

Processes, Год журнала: 2025, Номер 13(4), С. 935 - 935

Опубликована: Март 21, 2025

In recent years, exopolysaccharides (EPSs) have emerged as significant substances due to their impressive biological properties. This research intends analyze the EPS extracted from probiotic bacteria and assess its various activities. The promising isolated human breast milk was identified Lactiplantibacillus plantarum B7 by 16S rRNA sequencing. yield of this strain quantified 5.2 g/L. crude extract (EPSc) subjected purification chromatography on DEAE-cellulose Sephadex G-100 columns, giving two main fractions named EPSF1 EPSF2. Structural features were investigated HPLC, FTIR, GPC 1HNMR. Chromatographic analysis indicated that EPSF2 composed mannuronic acid, mannose glucose in a molar ratio 2.6:2.15:1.00 3.92:2.65:1.00 with molecular weight 4.36 × 104 5.27 105, respectively. Multiple vitro assays EPSc, showed potent radical scavenging activity DPPH, ABTS, hydroxyl (HRS) superoxide activity. Also, they reducing power 0.69, 0.61 0.58, respectively, at 1000 μg/mL. displayed negligible toxicity against WI-38 normal lung cells but had cytotoxic effects colon cancer (Caco-2), (IC50 = 122.13 ± 0.01, 72.5 0.12 81.6 0.1 μg/mL), HepG2 liver 112.5 60.3 62.0 0.03 μg/mL) prostate (PC3) 109.6 0.03, 65.7 0.01 70.3 0.04 μg/mL). While anti-inflammatory hemolysis inhibition 79.3 0.05, 93.5 0.05 87.9 0.03% 500 µg/mL, results indicate antioxidant, antitumor

Язык: Английский

Процитировано

0
Eco-friendly Nanoparticle Phytosynthesis via Plant Extracts: Mechanistic Insights, Recent Advances, and Multifaceted Uses DOI Creative Commons
Great Iruoghene Edo, Alice Njolke Mafe,

Ali B.M. Ali

и другие.

Nano TransMed, Год журнала: 2025, Номер unknown, С. 100080 - 100080

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Zinc‐Cobalt Bimetallic Organic Frameworks with Antioxidative and Osteogenic Activities for Periodontitis Treatment DOI
Hao Tang,

Yameng Yu,

Xinxin Zhan

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Periodontitis is a prolonged inflammatory disease caused by bacterial infection. Oxidative stress induced inflammation leads to excessive production of reactive oxygen species (ROS) and difficulties in bone tissue regeneration. ROS-scavenging agents regulate the periodontal microenvironment, which great significance treatment periodontitis. In this study, zinc-cobalt bimetallic organic framework (Zn/Co-MOF) constructed alleviate local resorption periodontitis cascading antioxidant activity. vitro experimental results show that Zn/Co-MOF not only provides effective cellular protection against ROS attack human marrow mesenchymal stem cells osteoblast precursor (MC3T3-E1), but also promotes osteogenic differentiation. vivo experiments rat models confirm Zn/Co-MOFs can reduce inflammation, osteoclasts, promote recovery alveolar height defects, beneficial for RNA sequencing regeneration mainly through activated Wnt pathways, accelerate Overall, exhibits capacity regeneration, making it promising strategy

Язык: Английский

Процитировано

0
Linc00963 up-regulation alleviates postmenopausal osteoporosis through suppression of miR-506-3p DOI Creative Commons
Qiang Li, Jian Zhao, Xiaoxia Yang

и другие.

Journal of Orthopaedic Surgery and Research, Год журнала: 2025, Номер 20(1)

Опубликована: Апрель 11, 2025

This study aimed to investigate the regulatory effect of linc00963 on postmenopausal osteoporosis and potential molecular mechanisms. Taking MC3T3-E1 cells as object, a cell cycle assay was used evaluate proliferation. mRNA levels Runx2, OCN, collagenia-1, OPG, RANKL RANK were detected. Dual luciferase reporter verified targeting relationship between miR-506-3p. A rat model established after ovariectomy in 32 Sprague-Dawley rats. The rats divided into sham group, OVX overexpression blank plasmid group. bone mineral density (BMD) femur measured by X-ray densitometer. Serum expression detected RT-qPCR. protein ALP, BGP serum ELISA. Cell studies have shown that alleviates down-regulating Animal showed compared with level, BMD, Ca, P, LEP, SOD, OPG group significantly decreased, while body weight, BGP, IL-6, IL-13, RANKL, increased. Compared use can improve above indexes play corresponding therapeutic menopausal Linc00963 is involved pathogenesis up-regulating miR-506-3p activating OPG/RANKL/RANK pathway. expected be target for osteoporosis.

Язык: Английский

Процитировано

0
Intelligent Nanomaterials Design for Osteoarthritis Managements DOI Open Access
Zhihao Chen, Xuan Zheng, Zhengzhi Mu

и другие.

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Март 30, 2025

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive degradation, pain, and diminished mobility, all of which collectively impair patients' quality life escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, temporary symptom relief, underscoring urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials nanomedicines offer promising solutions improving drug bioavailability, reducing effects providing targeted benefits. This review critically examines pathogenesis OA, highlights limitations existing treatments, explores latest innovations intelligent design OA therapy, with an emphasis on their engineered properties, mechanisms, translational potential clinical application. By compiling recent findings, this work aims inspire further exploration innovation nanomedicine, ultimately advancing development personalized therapies.

Язык: Английский

Процитировано

0