International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 33
Опубликована: Дек. 16, 2024
This
review
delves
into
the
efficacy
of
electrospun
nanofibers
as
structures
capable
neutralizing
Reactive
Oxygen
Species
(ROS),
thereby
aiding
in
acceleration
wound
repair.
ROS
occupy
a
dual
position
cellular
dynamics,
being
indispensable
for
intracellular
communication,
yet
they
potentially
exacerbate
oxidative
stress
which
can
stall
healing
trajectory.
The
method
electrospinning
synthesizes
distinguished
by
their
expansive
surface
area
relative
to
volume
and
notable
porosity,
rendering
them
optimally
suited
medical
endeavors,
particularly
frameworks
that
bolster
recuperation.
analysis
elucidates
diverse
roles
these
play,
from
enhancing
clot
formation
combating
microbial
invasion
mitigating
inflammation,
fostering
proliferation,
facilitating
angiogenesis—each
pivotal
component
effective
mending
wounds.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11519 - 11519
Опубликована: Окт. 26, 2024
Heart
Failure
with
Preserved
Ejection
Fraction
(HFpEF)
is
one
of
the
most
frequent
causes
heart
failure
in
world’s
population
(about
19–55%),
and
commonly
associated
a
high
rate
hospitalization
(almost
70–80%)
increased
mortality
(40–50%
5-year
timeframe).
The
elderly
are
more
often
affected,
higher
rates
hospitalizations
than
young
people,
currently
almost
70%
aged
65
years
old
has
HFpEF.
An
increase
cardiomyocyte
stiffness,
thus
resulting
diastolic
dysfunction,
filling
pressures
preserved
ejection
fraction
characteristics
features
disease.
In
addition,
among
various
HFpEF,
cardiac
amyloidosis
(CA)
can
provoke
dysfunction
wall
stiffness
directly
from
intercellular
deposition
insoluble
proteic
substances
their
toxic
activity.
Totally,
30
different
proteins
able
to
form
deposits,
but
frequently
involved
transthyretin
misfolded
monoclonal
immunoglobulin
light
chains,
which
bring
two
clinical
conditions
called
(ATTR)
light-chain
(AL).
Although
there
been
increasing
attention
on
ATTR-CA
recent
years,
actual
prevalence
remains
underestimated,
especially
people
advanced
age,
as
well
its
real
impact
cause
only
data
derived
autoptic
exams
available.
Moreover,
CA
itself
mimics
some
conflicting
use
predictive
scores
described
literature.
close
relationship
between
HFpEF
CA,
older
main
pathophysiological
mechanisms
bond
these
this
focused
review.
need
screen
red
flags
for
patients
urgently
advised,
because
prompt
recognition
disease
optimize
approach
an
early
therapeutic,
life-saving
choice.
International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 33
Опубликована: Дек. 16, 2024
This
review
delves
into
the
efficacy
of
electrospun
nanofibers
as
structures
capable
neutralizing
Reactive
Oxygen
Species
(ROS),
thereby
aiding
in
acceleration
wound
repair.
ROS
occupy
a
dual
position
cellular
dynamics,
being
indispensable
for
intracellular
communication,
yet
they
potentially
exacerbate
oxidative
stress
which
can
stall
healing
trajectory.
The
method
electrospinning
synthesizes
distinguished
by
their
expansive
surface
area
relative
to
volume
and
notable
porosity,
rendering
them
optimally
suited
medical
endeavors,
particularly
frameworks
that
bolster
recuperation.
analysis
elucidates
diverse
roles
these
play,
from
enhancing
clot
formation
combating
microbial
invasion
mitigating
inflammation,
fostering
proliferation,
facilitating
angiogenesis—each
pivotal
component
effective
mending
wounds.
