Development of a ROS-responsive, glutathione-functionalized injectable hydrogel system for controlled drug release DOI
Kai Hu,

Linlin Liang,

Jian Song

и другие.

Journal of Biomaterials Applications, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Oxidative stress arises from an imbalance between excessive production of reactive oxygen species (ROS) and the body’s antioxidant defenses. In neurodegenerative diseases, this leads to ROS accumulation, causing neuronal dysfunction cell death. Traditional drug therapies often fail address dynamic nature neuroinflammation, limiting their therapeutic efficacy. To overcome challenge, we have developed innovative ROS-responsive injectable hydrogel. This hydrogel is designed detect oxidative sensitively release glutathione in a controlled manner, thereby modulating inflammation restoring damaged immune microenvironment facilitate tissue repair. The was synthesized by crosslinking polyvinyl alcohol (PVA) with sodium alginate modified 3-aminophenylboronic acid (Alg-PBA). We investigated hydrogel’s formation mechanism analyzed how component variations affect its morphological rheological properties. Our findings demonstrate that optimal Alg-PBA PVA weight ratio 2:1 yields superior mechanical strength. Glutathione (GSH) studies confirmed pronounced behavior. Furthermore, biocompatibility assessments revealed loaded 100 μg/mL GSH exhibited excellent compatibility significantly inhibited apoptosis under oxygen-glucose deprivation (OGD) conditions. work presents promising strategy for treating inflammation-related diseases provides valuable insights designing next-generation hydrogels adapt injury-responsive microenvironments.

Язык: Английский

Signaling Paradigms of H2S-Induced Vasodilation: A Comprehensive Review DOI Creative Commons
Constantin Munteanu, Cristina Raluca Gh. Popescu, Andreea-Iulia Vlădulescu-Trandafir

и другие.

Antioxidants, Год журнала: 2024, Номер 13(10), С. 1158 - 1158

Опубликована: Сен. 25, 2024

Hydrogen sulfide (H

Язык: Английский

Процитировано

10
Exploring Medical Gas Therapy in Hemorrhagic Stroke Treatment: A Narrative Review DOI Creative Commons
Liang Cao, Chen Chen,

Wenjun Pi

и другие.

Nitric Oxide, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Hemorrhagic stroke (HS) is a neurological disorder caused by the rupture of cerebral blood vessels, resulting in seeping into brain parenchyma and causing varying degrees impairment, including intracerebral hemorrhage (ICH) subarachnoid (SAH). Current treatment methods mainly include hematoma evacuation surgery conservative treatment. However, these have limited efficacy enhancing function prognosis. The current challenge treating HS lies inhibiting occurrence progression secondary damage after bleeding, which key factor affecting prognosis patients. Studies shown that medical gas therapy gaining more attention has demonstrated various levels neuroprotective effects on central nervous system disorders, such as hyperbaric oxygen, hydrogen sulfide, nitric oxide, carbon monoxide, other inhalable molecules. These molecules primarily improve tissue dysfunction regulating inflammation, oxidative stress, apoptosis, processes. many gasses also possess neurotoxic properties. Therefore, use gases deserves further exploration research. In this review, we will elucidate therapeutic study advances HS.

Язык: Английский

Процитировано

0
Development of a ROS-responsive, glutathione-functionalized injectable hydrogel system for controlled drug release DOI
Kai Hu,

Linlin Liang,

Jian Song

и другие.

Journal of Biomaterials Applications, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Oxidative stress arises from an imbalance between excessive production of reactive oxygen species (ROS) and the body’s antioxidant defenses. In neurodegenerative diseases, this leads to ROS accumulation, causing neuronal dysfunction cell death. Traditional drug therapies often fail address dynamic nature neuroinflammation, limiting their therapeutic efficacy. To overcome challenge, we have developed innovative ROS-responsive injectable hydrogel. This hydrogel is designed detect oxidative sensitively release glutathione in a controlled manner, thereby modulating inflammation restoring damaged immune microenvironment facilitate tissue repair. The was synthesized by crosslinking polyvinyl alcohol (PVA) with sodium alginate modified 3-aminophenylboronic acid (Alg-PBA). We investigated hydrogel’s formation mechanism analyzed how component variations affect its morphological rheological properties. Our findings demonstrate that optimal Alg-PBA PVA weight ratio 2:1 yields superior mechanical strength. Glutathione (GSH) studies confirmed pronounced behavior. Furthermore, biocompatibility assessments revealed loaded 100 μg/mL GSH exhibited excellent compatibility significantly inhibited apoptosis under oxygen-glucose deprivation (OGD) conditions. work presents promising strategy for treating inflammation-related diseases provides valuable insights designing next-generation hydrogels adapt injury-responsive microenvironments.

Язык: Английский

Процитировано

0