Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes

Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 8 - 8

Опубликована: Янв. 1, 2025

Each year, the number of cases strokes and deaths due to this is increasing around world. This could be work stress, lifestyles, unhealthy food habits, several other reasons. Currently, there are traditional methods like thrombolysis mechanical thrombectomy for managing strokes. The current approach has limitations, delayed diagnosis, limited therapeutic delivery, risks secondary injuries. So, a need some effective reliable management strokes, which help in early diagnosis followed by treatment Nanotechnology played an immense role recently, it emerged as transformative solution offering innovative diagnostic tools strategies. Nanoparticles (NPs) belonging classes, including metallic (metallic metal oxide), organic (lipids, liposome), carbon, can cross blood–brain barrier may exhibit potential various Moreover, these NPs have exhibited promise improving imaging specificity delivery precise drug real-time monitoring efficacy. Nanomaterials cerium oxide (CeO2) liposome-encapsulated agents neuroprotective properties that reduce oxidative stress promote neuroregeneration. In present article, authors emphasized significant advancements nanomedicine stroke, NPs-based systems, neuroregenerative therapies, multimodal advancements.

Язык: Английский

---

Nanoparticle Strategies for Treating CNS Disorders: A Comprehensive Review of Drug Delivery and Theranostic Applications

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13302 - 13302

Опубликована: Дек. 11, 2024

This review aims to address the significant challenges of treating central nervous system (CNS) disorders such as neurodegenerative diseases, strokes, spinal cord injuries, and brain tumors. These are difficult manage due complexity disease mechanisms protective blood–brain barrier (BBB), which restricts drug delivery. Recent advancements in nanoparticle (NP) technologies offer promising solutions, with potential applications delivery, neuroprotection, neuroregeneration. By examining current research, we explore how NPs can cross BBB, deliver medications directly targeted CNS regions, enhance both diagnostics treatment. Key NP strategies, passive targeting, receptor-mediated transport, stimuli-responsive systems, demonstrate encouraging results. Studies show that may improve minimize side effects, increase therapeutic effectiveness models Alzheimer’s, Parkinson’s, stroke, glioblastoma. thus represent a approach for disorder management, combining delivery diagnostic capabilities enable more precise effective treatments could significantly benefit patient outcomes.

Язык: Английский

---

Targeting tumor microenvironment with RGD-functionalized nanoparticles for precision cancer therapy

Cancer Letters, Год журнала: 2025, Номер unknown, С. 217536 - 217536

Опубликована: Фев. 1, 2025

Язык: Английский

---

Polymer-based nanocarriers to transport therapeutic biomacromolecules across the blood-brain barrier

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Therapeutic biomacromolecules such as genetic material, antibodies, growth factors and enzymes represent a novel therapeutic alternative for neurological diseases disorders. In comparison to traditional therapeutics, which are mainly based on small molecular weight drugs that address the symptoms of these disorders, can reduce undesired side effects target specific pathological pathways, thus paving way towards personalized medicine. However, undergo degradation/denaturation processes in physiological environment show poor capacity cross blood-brain barrier (BBB). Consequently, they rarely reach central nervous system (CNS) their active form. Herein, we critically overview several polymeric nanocarriers protect deliver across BBB. Polymeric first categorized architecture (biodegradable solid nanoparticles, nanogels, dendrimers, self-assembled nanoparticles), ultimately determines physico-chemical properties function. The available formulations then thoroughly analyzed, placing particular attention those strategies ensure stability during encapsulation process promote passage BBB by controlling physical (e.g., mechanical properties, size, surface charge) chemical functional groups, targeting motifs) properties. Accordingly, this review gives unique perspective delivery BBB, representing concise, complete easy-to-follow guide, will be high interest chemists, material scientists, pharmacologists biologists. Besides, it also provides critical about limited clinical translation systems. STATEMENT OF SIGNIFICANCE: increasing incidence disorders is major health concern. use has been placed spotlight many investigations. reaching concentration levels restricted and, thus, represents main challenge when developing efficient therapies. provide discussion into system, highlighting potential future directions overcome current challenges.

Язык: Английский

---

Molecularly imprinted nanoparticles hitchhiking on neutrophils for precise treatment of ischemic stroke

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 689, С. 137246 - 137246

Опубликована: Март 4, 2025

Язык: Английский

---

Enhanced Vitamin D3 Adsorption Through Novel Hydrophobic Halloysite–Alginate Biopolymer Composites

Polymers, Год журнала: 2025, Номер 17(8), С. 1083 - 1083

Опубликована: Апрель 17, 2025

This study presents a sustainable strategy to enhance polymer encapsulation, adsorption, and functional properties by chemically modifying sodium alginate with hydrophobic groups. Hydrophobic derivatives were synthesized via solvent-free method using hexadecyl trimethylammonium bromide, resulting in nanoparticles capable of effectively capturing non-polar compounds. To further improve compatibility within alginate-based biocomposites, halloysite nanotubes modified through ball milling surfactant-assisted treatments. The nanocomposites (MBHA MHHA) exhibited significantly enhanced adsorption controlled release behavior, as confirmed FTIR analysis ester conjugation. Vitamin D3 followed the Langmuir isotherm, high correlation coefficients (R2 = 0.998 for MBHA R2 0.991 MHHA), indicating monolayer on homogenous surface. Kinetic modeling revealed that process adhered pseudo-second-order model 0.9969 0.999 suggesting chemisorption was dominant rate-controlling mechanism. These results demonstrate critical role surface modification designing nano-engineered biopolymers superior stability, profiles, offering applications medicine, agriculture, environmental remediation.

Язык: Английский

---

ROS-responsive Chitosan Bilirubin Nanoparticles loaded with Statin for Treatment of Cerebral Ischemia

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Cerebral ischemia impairs blood circulation, leading to elevated reactive oxygen species (ROS) production. A ROS-responsive delivery of drugs can enhance the therapeutic efficacy and minimize side effects. There is insufficient evidence on impact nanoparticles ischemic stroke. We developed chitosan–bilirubin (ChiBil) target acute lesions investigated effect atorvastatin-loaded ChiBil. randomly assigned rats with transient middle cerebral artery occlusion (MCAO) 4 groups: saline, Statin, ChiBil, ChiBil-Statin. These groups were treated daily via tail vein for 7 d. Behavioral assessment, magnetic resonance (MR) imaging, evaluation neuroinflammation, blood–brain barrier (BBB) integrity, apoptosis, neurogenesis after stroke conducted. In vitro, results showed nanoparticle uptake reduced intracellular ROS, lipid peroxidation, inflammatory cytokines (IL-6 TNF-α). vivo, improved motor deficits decreased infarct volumes MR images in ChiBil-Statin group compared Control day ( P < 0.05). Furthermore, expression such as IL-1β IL-6 was Improvements BBB observed group. The findings demonstrated that intravenous multifunctional could effectively deliver brain, exerting marked synergistic pleiotropic neuroprotective Therefore, holds promise a targeted therapy vascular diseases characterized by increased ROS production, new avenues future research potential clinical applications.

Язык: Английский

---

Current Status of Research on Nanomaterials Combined with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke

NeuroMolecular Medicine, Год журнала: 2024, Номер 26(1)

Опубликована: Дек. 7, 2024

Язык: Английский

---

Dual-stimuli responsive nanoparticles for co-delivery of small molecules to promote neural differentiation of human iPSCs

Nanoscale, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

The differentiation of human induced pluripotent stem cells (hiPSCs) into neural progenitor (NPCs) is a promising approach for the treatment neurodegenerative diseases and regenerative medicine.

Язык: Английский

---