AQP3-liposome@GelMA promotes overloaded-induced degenerated disc regeneration via IBSP/ITG αVβ3/AKT pathway DOI
Junxian Hu, Yibo Zhu, Xiaoxiao Li

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 292, С. 139238 - 139238

Опубликована: Дек. 27, 2024

Язык: Английский

Therapeutic Potential of Quercitrin in Intervertebral Disc Degeneration: Targeting Pyroptosis and Inflammation DOI
Xinyu Wu, Qing Pan, Chao Yao

и другие.

Опубликована: Янв. 1, 2025

AbstractBackground: Intervertebral disc degeneration (IDD) is the predominant cause of low back pain (LBP), that leads to significant disability and imposes a substantial socioeconomic burden. Despite its prevalence, effective treatment for IDD has yet be fully established. This study aimed explore therapeutic potential quercitrin (QUE) in development elucidate underlying mechanisms.Methods:: In vitro, we investigated effects QUE on ECM metabolism, inflammatory response pyroptosis IL-1β-stimulated nucleus pulposus cells (NPCs), along with mechanisms. vivo, mice lumbar spinal instability (LSI) was established determined impact progression.Results: significantly alleviated inflammation maintained homeostasis under IL-1β stimulation NPCs. Moreover, appeared inhibit pyroptosis, which closely related intense response. Notably, protective abrogated upon inhibition TRIM31 activity, indicating mediated suppression crucial QUE.Con clusion: plays an important role alleviating within NPCs, thereby slowing progression IDD. Therefore, might emerge as promising candidate IDD, holding clinical application future.

Язык: Английский

Процитировано

0
HMGB1-mediated macrophage regulation of NF-κB activation and MMP3 upregulation in nucleus pulposus cells: A critical mechanism in the vicious cycle of intervertebral disc degeneration DOI
Shixin Lu,

Ming Li,

Ziying Cheng

и другие.

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111628 - 111628

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Therapeutic potential of quercitrin in intervertebral disc degeneration: Targeting pyroptosis and inflammation DOI Creative Commons
Xinyu Wu, Qing Pan, Chao Yao

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 156, С. 114680 - 114680

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0
The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair DOI

Yingjie Mai,

Siying Wu, Penghui Zhang

и другие.

Bioactive Materials, Год журнала: 2024, Номер 45, С. 19 - 40

Опубликована: Ноя. 9, 2024

Язык: Английский

Процитировано

1
AQP3-liposome@GelMA promotes overloaded-induced degenerated disc regeneration via IBSP/ITG αVβ3/AKT pathway DOI
Junxian Hu, Yibo Zhu, Xiaoxiao Li

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 292, С. 139238 - 139238

Опубликована: Дек. 27, 2024

Язык: Английский

Процитировано

0