Polyetheretherketone biomaterials and their current progress, modification-based biomedical applications and future challenges
Materials & Design,
Год журнала:
2025,
Номер
unknown, С. 113716 - 113716
Опубликована: Фев. 1, 2025
Язык: Английский
GelMA Hydrogels Integrated With aptamer CH6‐Functionalized Tetrahedral DNA Nanostructures for Osteoporotic Mandibular Regeneration
Macromolecular Bioscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Osteoporotic
bone
regeneration
is
challenging
due
to
impaired
formation.
Tetrahedral
DNA
nanostructures
(TDN),
promising
nucleic
acid
nanomaterials,
have
garnered
attention
for
their
potential
in
osteoporotic
mandibular
owing
ability
enhance
cellular
activity
and
promote
osteogenic
differentiation.
Osteoblasts
play
a
critical
role
regeneration;
however,
intracellular
delivery
of
TDN
into
osteoblasts
remains
difficult.
In
this
study,
novel
osteoblast-targeted
CH6
aptamer-functionalized
(TDN-CH6)
aimed
develop
regeneration.
This
results
demonstrated
that
TDN-CH6
exhibits
superior
osteoblast
specificity
efficient
recruitment
fracture
sites.
Furthermore,
significantly
enhances
differentiation
compared
alone.
Notably,
Gelatin
Methacryloyl
(GelMA)
hydrogels
incorporating
shows
improved
biological
performance
are
favorable
regeneration,
suggesting
platform
represents
strategy
addressing
complex
defects.
Язык: Английский
Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 29, 2025
Abstract
This
study
examines
the
biocompatibility,
osteogenic
potential,
and
effectiveness
of
polyether
ether
ketone
(PEEK)
composites
for
treating
osteonecrosis,
seeking
to
establish
a
theoretical
basis
clinical
application.
A
range
PEEK
composite
materials,
including
sulfonated
(SPEEK),
polydopamine-sulfonated
(SPEEK-PDA),
bone-forming
peptide-poly-dopamine-sulfonated
(SPEEK-PDA-BFP),
vascular
endothelial
growth
factor-poly-dopamine-sulfonated
(SPEEK-PDA-VEGF),
were
constructed
by
concentrated
sulfuric
acid
sulfonation,
polydopamine
modification
grafting
bioactive
factors.
The
experiments
involved
adult
male
New
Zealand
rabbits
aged
24–28
weeks
weighing
2.6–4
kg.
SPEEK-PDA-BFP
possesses
smallest
water
contact
angle,
indicating
highest
hydrophilicity,
with
its
surface
characterized
rich
density
clustered
BFP
particles.
exhibits
superior
adhesion,
proliferation,
differentiation
capabilities,
along
pronounced
bacteriostatic
effects,
which
are
attributed
dense
particle
clusters.
facilitates
formation
regular
bone
trabeculae.
Comparative
on
osteonecrosis
SPEEK-PDA-VEGF
highlighted
mature
trabeculae
angiogenic
protein
CD31
around
SPEEK-PDA-VEGF.
materials
have
good
activity
repair
activity.
In
particular,
best
effect
repair.
Язык: Английский
Manganese Empowered Electronic Modulated Nanocatalysts Facilitate Bone Reconstruction via Osteoclastogenesis Inhibition and Osteogenesis Activation Bistimulatory Strategy
Composites Part B Engineering,
Год журнала:
2025,
Номер
unknown, С. 112364 - 112364
Опубликована: Март 1, 2025
Язык: Английский
Ultrasound-responsive Smart Biomaterials for Bone Tissue Engineering
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Bone
defects
resulting
from
trauma,
tumors,
or
other
injuries
significantly
impact
human
health
and
quality
of
life.
However,
current
treatments
for
bone
are
constrained
by
donor
shortages
immune
rejection.
tissue
engineering
has
partially
alleviated
the
limitations
traditional
repair
methods.
The
development
smart
biomaterials
that
can
respond
to
external
stimuli
modulate
biofunctions
become
a
prominent
area
research.
Ultrasound
technology
is
regarded
as
an
optimal
"remote
controller"
"trigger"
biomaterials.
This
review
reports
comprehensive
systematic
overview
ultrasound-responsive
It
presents
fundamental
theories
repair,
definition
ultrasound,
its
applications.
Furthermore,
summarizes
ultrasound
effect
mechanisms
their
roles
in
including
detailed
studies
on
anti-inflammation,
immunomodulation,
cell
therapy.
Finally,
advantages
future
prospects
this
field
discussed.
Язык: Английский
Piezoelectric poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) microspheres for collagen regeneration and skin rejuvenation
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Март 12, 2025
Introduction
Skin
aging
is
an
inevitable
physiological
process
driven
by
factors
like
cellular
senescence,
ultraviolet
radiation
(UV)
radiation,
and
environmental
pollutants.
A
key
feature
the
accelerated
collagen
degradation
in
dermal
extracellular
matrix,
leading
to
visible
signs
such
as
sagging,
wrinkles,
hyperpigmentation.
Traditional
fillers,
hyaluronic
acid
collagen-based
offer
only
temporary
volume
enhancement
without
stimulating
regeneration.
Studies
have
shown
that
electrical
signals
generated
piezoelectric
materials
can
promote
tissue
Methods
This
study
explored
potential
of
PHBHHx
microspheres
innovative
skin
filler
for
enhancing
regeneration
improving
maxillofacial
aesthetics,
with
aid
low-intensity
pulsed
ultrasound
(LIPUS)
stimulation.
comprehensive
characterizations
were
conducted,
their
stimulate
was
assessed
using
a
subcutaneous
injection
model
New
Zealand
white
rabbits.
Results
The
results
indicated
exhibited
stable
properties,
great
properties
excellent
biocompatibility.
Moreover,
when
stimulated
LIPUS,
collagen-regenerating
effect
further
enhanced,
histological
analysis
revealed
denser
more
organized
structures
LIPUS-stimulated
group.
Discussion
These
findings
highlight
advanced
biomaterial
applications
aesthetic
medicine,
particularly
promoting
rejuvenation.
Язык: Английский
Injectable Piezoelectric Hydrogel Promotes Tendon–Bone Healing via Reshaping the Electrophysiological Microenvironment and M2 Macrophage Polarization
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Rotator
cuff
tear
(RCT)
is
a
common
musculoskeletal
disease
that
poses
challenges
for
functional
regeneration
of
the
tendon-bone
interface
(TBI).
The
transition
TBI
between
soft
and
hard
tissues
determines
its
structural
physiological
environment
complexity.
Here,
we
present
an
injectable
biopiezoelectric
material
PVA/CNF/BTO@PDA
(Piezoelectric)
hydrogel
based
on
three-dimensional
(3D)
printing
inspired
by
"muscle-electrical
coupling".
This
Piezoelectric
indicated
desirable
piezoelectric
mechanical
properties,
excellent
biodegradability,
biosafety.
In
vitro,
electrical
stimulation
from
Flexcell
Tissue
Train
system
promoted
polarization
macrophages
to
M2
phenotype,
directing
targeted
aggregation
zonal-specific
differentiation
bone
mesenchymal
stem
cells
(BMSCs)
formation.
Also,
optimal
could
alleviate
inflammatory
factor
expression
regulate
osteotendinogenic
BMSCs
under
H2O2/IL-1β
inflammation
environment.
Furthermore,
in
vivo
application
demonstrates
regenerative
potential,
indicating
repair
with
significantly
accelerates
promotes
healing
chronic
RCT
model.
Therefore,
our
findings
propose
new
therapeutic
strategy
enhance
treatment
outcomes
RCT.
Язык: Английский
3D printed shape-memory piezoelectric scaffolds with in-situ self-power properties for bone defect repair
Bing Li,
Yichao Ma,
Kanwal Fatima
и другие.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 24, 2025
Electrical
stimulation
has
been
shown
to
regulate
early
immunity
and
late-stage
osteogenesis
in
bone
repair.
However,
achieving
in-situ
electrical
the
form
of
self-power
vivo
during
initial
postoperative
stages
when
patients
have
limited
mobility
remains
challenging.
In
this
study,
we
developed
a
3D-printed
self-powered
composite
scaffold
composed
shape
memory
polyurethane
elastomers
(SMPU)
polyvinylidene
fluoride
(PVDF)
piezoelectric
nanofibers.
The
demonstrates
excellent
performance,
allowing
for
minimally
invasive
implantation.
During
process,
can
provide
mechanical
force
PVDF
nanofibers
generate
charge.
Therefore,
was
achieved
through
integration
process
effects,
it
be
used
period.
Additionally,
output
voltage
under
continuous
stimulation,
indicating
that
apply
sustained
rehabilitation
exercises
regain
mobility.
Both
cell
experiments
animal
studies
confirmed
effectively
immune
microenvironment
enhance
osteogenesis.
This
study
successfully
achieves
by
integrating
which
is
expected
an
effective
repair
strategy
tissue
engineering.
Язык: Английский
Emerging Piezoelectric Metamaterials for Biomedical Applications
Опубликована: Ноя. 21, 2024
Emerging
piezoelectric
metamaterials
hold
immense
promise
for
biomedical
applications
by
merging
the
intrinsic
electrical
properties
of
piezoelectricity
with
precise
architecture
metamaterials.
This
review
provides
a
comprehensive
overview
various
materials-
such
as
molecular
crystals,
ceramics,
and
polymers-known
their
exceptional
performance
biocompatibility.
We
explore
advanced
engineering
approaches,
including
design,
supramolecular
packing,
3D
assembly,
which
enable
customization
targeted
applications.
Particular
attention
is
given
to
pivotal
role
metamaterial
structuring
in
development
0D
spheres,
1D
fibers
tubes,
2D
films,
scaffolds.
Key
applications,
tissue
engineering,
drug
delivery,
wound
healing,
biosensing,
are
discussed
through
illustrative
examples.
Finally,
article
addresses
critical
challenges
future
directions,
aiming
drive
further
innovations
biomaterials
next-generation
healthcare
technologies.
Язык: Английский