NCAPG-mediated CDK1 promotes malignant progression of non-small cell lung cancer via ERK signaling activation DOI
Yilin Wu, Ming Yang, Ming Chen

и другие.

American Journal of Cancer Research, Год журнала: 2024, Номер 14(11), С. 5338 - 5350

Опубликована: Янв. 1, 2024

Non-SMC condensing I complex subunit G (NCAPG) has been implicated in tumor progression. However, its role, potential mechanism and prognostic significance human non-small cell lung cancer (NSCLC) remain elusive. Through the conjoint analysis of TCGA The Gene Expression Omnibus (GEO) databases, we confirmed that NCAPG is an upregulated gene. value was elucidated through data analysis. functional roles mechanistic insights NSCLC growth metastasis were evaluated vitro vivo. expression significantly increased NSCLC. Multivariate Cox regression demonstrated independent factor patients with high correlated lymphatic metastasis. Additionally, effectively promoted In terms mechanism, interaction between Cyclin-dependent kinase 1 (CDK1) promotes phosphorylation Extracellular signal-regulated (ERK). Overall, our results reveal key role highlight regulatory function NCAPG/CDK1/ERK axis regulating progression NSCLC, providing prognosis therapeutic targets for treatment

Язык: Английский

Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies DOI Creative Commons
Liping Chen,

Qingqing Li

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101782 - 101782

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
NCAPG-mediated CDK1 promotes malignant progression of non-small cell lung cancer via ERK signaling activation DOI
Yilin Wu, Ming Yang, Ming Chen

и другие.

American Journal of Cancer Research, Год журнала: 2024, Номер 14(11), С. 5338 - 5350

Опубликована: Янв. 1, 2024

Non-SMC condensing I complex subunit G (NCAPG) has been implicated in tumor progression. However, its role, potential mechanism and prognostic significance human non-small cell lung cancer (NSCLC) remain elusive. Through the conjoint analysis of TCGA The Gene Expression Omnibus (GEO) databases, we confirmed that NCAPG is an upregulated gene. value was elucidated through data analysis. functional roles mechanistic insights NSCLC growth metastasis were evaluated vitro vivo. expression significantly increased NSCLC. Multivariate Cox regression demonstrated independent factor patients with high correlated lymphatic metastasis. Additionally, effectively promoted In terms mechanism, interaction between Cyclin-dependent kinase 1 (CDK1) promotes phosphorylation Extracellular signal-regulated (ERK). Overall, our results reveal key role highlight regulatory function NCAPG/CDK1/ERK axis regulating progression NSCLC, providing prognosis therapeutic targets for treatment

Язык: Английский

Процитировано

1