A dissolving microneedle patch provides minimally invasive riboflavin delivery and enhances corneal crosslinking in keratoconus therapy
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Corneal
collagen
cross-linking
(CXL)
is
an
effective
surgical
approach
to
halt
the
progression
of
keratoconus.
A
key
challenge
lies
in
maintaining
epithelial
integrity
while
achieving
sufficient
stromal
riboflavin
(RF)
concentration
ensure
CXL
efficacy.
Additionally,
efficacy
under
RF-mediated
still
has
room
for
improvement.
In
this
study,
we
developed
a
silk
fibroin
methacryloyl
(SFMA)-based
dissolvable
microneedle
(MN)
system
(termed
RF/SFMA
MNs).
vitro
and
ex
vivo
experiments
showed
that
MNs
exhibited
excellent
mechanical
strength,
dissolution
profile,
drug
release
profile
biocompatibility.
vivo,
were
characterized
by
suitable
corneal
penetration
capability
through
minimally
invasive
approach.
with
different
RF
concentrations
(0-2%)
tip
lengths
(330-800
µm)
tested.
1%
length
550
µm
achieved
permeation
delivery
depth
within
stroma.
Furthermore,
integrating
SFMA
into
procedure
allowed
mediate
multiple
crosslinking
events
between
collagen,
resulting
enhanced
increase
biomechanical
strength
compared
conventional
Epi-on
Epi-off
strategies.
Over
two-week
observation
period,
MN-based
biomechanics
more
effectively
than
CXL,
arrangement
without
adverse
effects
on
epithelium
or
endothelium.
Therefore,
MNs,
designed
efficacy,
present
promising
innovative
optimize
treatment
Язык: Английский
Responsive Microneedles for Diagnostic and Therapeutic Applications of Ocular Diseases
Small Methods,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Abstract
Traditional
ophthalmic
formulations
are
characterized
by
low
bioavailability,
short
intraocular
retention
time,
strong
irritation,
and
failure
to
achieve
the
expected
therapeutic
effect
due
special
physiological
structure
of
eye
existence
many
barriers.
Microneedle
drug
delivery
is
a
novel
transdermal
modality.
Responsive
microneedles
defined
as
controllably
releasing
payloads
in
response
stimuli,
including
pH
levels,
temperature,
enzymes,
reactive
oxygen
species
(ROS),
well
external
stimuli
such
magnetic
fields
light.
In
addition
inheriting
advantages
traditional
microneedles,
which
include
enhanced
targeting
permeability,
non‐invasiveness,
painless
application,
integration
with
stimulus‐responsive
materials
enables
responsive
personalized
precision
process,
further
increases
accuracy
efficiency
ocular
treatments,
making
on‐demand
possible.
This
article
systematically
reviews
classification,
mechanisms,
characteristics
provides
detailed
introduction
their
diagnostic
applications
real‐time
monitoring
potential
diseases,
aiming
offer
insights
for
treatment
diseases
future.
Язык: Английский
Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment
Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1571 - 1571
Опубликована: Дек. 9, 2024
Microneedles
(MNs),
composed
of
multiple
micron-scale
needle-like
structures
attached
to
a
base,
offer
minimally
invasive
approach
for
transdermal
drug
delivery
by
penetrating
the
stratum
corneum
and
delivering
therapeutic
agents
directly
epidermis
or
dermis.
Hydrogel
microneedles
(HMNs)
stand
out
among
various
MN
types
due
their
excellent
biocompatibility,
high
drug-loading
capacity,
tunable
drug-release
properties.
This
review
systematically
examines
matrix
materials
fabrication
methods
HMN
systems,
highlighting
advancements
in
natural
synthetic
polymers,
explores
applications
treating
conditions
such
as
wound
healing,
hair
loss,
cardiovascular
diseases,
cancer.
Furthermore,
potential
HMNs
disease
diagnostics
is
discussed.
The
identifies
key
challenges,
including
limited
mechanical
strength,
efficiency,
lack
standardization,
while
proposing
strategies
overcome
these
issues.
With
integration
intelligent
design
enhanced
control
over
dosage
safety,
are
poised
revolutionize
expand
personalized
medicine.
Язык: Английский