Recent advance on extracellular vesicle labeling: From strategy to probe DOI
Sijung Hu,

Xinwen Chang,

Qiaojiao Ding

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216601 - 216601

Опубликована: Март 10, 2025

Язык: Английский

Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair DOI Creative Commons

Lei Qi,

Jing Wang,

Jinge Yan

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 12, 2025

Senescent mandibular bone repair poses a formidable challenge without completely satisfactory strategy. Endogenous cell recruitment and osteogenic differentiation are two sequential stages in regeneration, disruptions these processes present significant obstacles to senescent repair. To address issues, engineered extracellular vesicles (EV) with stem functions were developed. This study demonstrated that Apt19s-engineered (Apt19s-EV) recognize recruit marrow mesenchymal cells derived from old rats (O-BMSCs) specifically effectively. MiR-376b-5p, identified by RNA sequencing transfection, was significantly decreased O-BMSCs, it selected construct miR-376b-5p-engineered (376b-EV). 376b-EV could promote osteogenesis alleviate senescence of O-BMSCs targeting Camsap1. combine the advantages Apt19s miR-376b-5p, dual (Apt-376b-EV) comprising both miR-376b-5p modifications constructed. further validate its function, Gelatin methacryloyl (GelMA) hydrogel used as carrier Apt-376b-EV@GelMA delivery system. The vitro results have sequentially. Notably, vivo also showed sequentially endogenous enhance new formation fracture critical-sized defect models. In summary, vesicles, Apt-376b-EV, offer an appealing solution for recruiting promoting microenvironment, which may broaden clinical applications EV provide valuable strategies treating bone-related diseases future work.

Язык: Английский

Процитировано

2
Chitosan–exosome synergy: Advanced cell-free scaffold approaches for bone tissue engineering DOI

Nivetha Suresh,

Abinaya Shanmugavadivu, N. Selvamurugan

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140753 - 140753

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
The roles and therapeutic potential of exosomal non-coding RNAs in microglia-mediated intercellular communication DOI

Hu-Bo Yang,

Ding-Ci Lu,

Min Shu

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 148, С. 114049 - 114049

Опубликована: Янв. 16, 2025

Язык: Английский

Процитировано

0
Advances in lacrimal gland organoid development: Techniques and therapeutic applications DOI
Ahmed Abdal Dayem, Soo Bin Jang,

Nahee Lim

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 183, С. 117870 - 117870

Опубликована: Янв. 26, 2025

Язык: Английский

Процитировано

0
Extracellular vesicle as a next-generation drug delivery platform for rheumatoid arthritis therapy DOI
Yi Jin, Cong Xu, Yujuan Zhu

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113610 - 113610

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

0
Recent advance on extracellular vesicle labeling: From strategy to probe DOI
Sijung Hu,

Xinwen Chang,

Qiaojiao Ding

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216601 - 216601

Опубликована: Март 10, 2025

Язык: Английский

Процитировано

0