Electron Pump and Photon Trap Effect-Derived Selective Antitumor of Fe-Ppy@CaO2-Modified Polyetheretherketone for Bone Tumor Therapy DOI

Xingdan Liu,

Haifeng Zhang,

Shiwei Guan

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Bone tumors with high mortality and disability have become a major clinical challenge. Herewith, it is necessary to design materials for bone tumor therapy repair. In this work, Fe-doped polypyrrole (Fe-Ppy) CaO2 are constructed on sulfonated polyetheretherketone (SP) form multistage-responsive coating. The coating achieves long-lasting antitumor through chemodynamic (CDT), photothermal (PTT), combined immunotherapy. Fe-Ppy acts as an electron pump replenish Fe2+ oxidizing -NH- -N+-, which lasts the Fenton reaction persistently produces reactive oxygen species (ROS) in microenvironment (TME). selectively provides exogenous H2O2 response TME boost cycle. Stronger near-infrared light absorption due Fe doping more photon traps caused by porous structure-induced scattering refraction diminishment improve conversion of modified SP. Furthermore, ROS effective enhance M1 activation secrete TNF-α IFN kill cells. After therapy, Fe-Ppy@CaO2-modified SP could adaptively switch macrophage M2 promote osteogenesis abolishment NIR stimulation. summary, ROS, enhanced conversion, immunomodulation potential candidate tissue

Язык: Английский

Electron Pump and Photon Trap Effect-Derived Selective Antitumor of Fe-Ppy@CaO2-Modified Polyetheretherketone for Bone Tumor Therapy DOI

Xingdan Liu,

Haifeng Zhang,

Shiwei Guan

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Bone tumors with high mortality and disability have become a major clinical challenge. Herewith, it is necessary to design materials for bone tumor therapy repair. In this work, Fe-doped polypyrrole (Fe-Ppy) CaO2 are constructed on sulfonated polyetheretherketone (SP) form multistage-responsive coating. The coating achieves long-lasting antitumor through chemodynamic (CDT), photothermal (PTT), combined immunotherapy. Fe-Ppy acts as an electron pump replenish Fe2+ oxidizing -NH- -N+-, which lasts the Fenton reaction persistently produces reactive oxygen species (ROS) in microenvironment (TME). selectively provides exogenous H2O2 response TME boost cycle. Stronger near-infrared light absorption due Fe doping more photon traps caused by porous structure-induced scattering refraction diminishment improve conversion of modified SP. Furthermore, ROS effective enhance M1 activation secrete TNF-α IFN kill cells. After therapy, Fe-Ppy@CaO2-modified SP could adaptively switch macrophage M2 promote osteogenesis abolishment NIR stimulation. summary, ROS, enhanced conversion, immunomodulation potential candidate tissue

Язык: Английский

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