The type I IFN-IL-27 axis promotes mRNA vaccine-induced CD8+T cell responses DOI Open Access
Anthony T. Phan, Emily Aunins, Elisa Cruz-Morales

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

The ability of lipid nanoparticle (LNP)-delivered mRNA vaccines to induce type I IFNs is critical promote CD8 + T cell responses. studies presented here indicate that immunization with nucleoside modified mRNA-LNP drives myeloid expression the cytokine IL-27, which acts on antigen-specific cells sustain expansion. In vitro and in vivo revealed IFN signaling necessary for mRNA-LNP-induced IL-27 production, failed KO mice, IFNAR1-deficient mice particles also encode restored addition, mRNA-LNPs served as an adjuvant improved cytolytic responses therapeutic efficacy drive anti-pathogen anti-tumor immunity. These highlight central role induced this augment functionality response prophylactic or immunization.

Язык: Английский

The type I IFN-IL-27 axis promotes mRNA vaccine-induced CD8+T cell responses DOI Open Access
Anthony T. Phan, Emily Aunins, Elisa Cruz-Morales

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

The ability of lipid nanoparticle (LNP)-delivered mRNA vaccines to induce type I IFNs is critical promote CD8 + T cell responses. studies presented here indicate that immunization with nucleoside modified mRNA-LNP drives myeloid expression the cytokine IL-27, which acts on antigen-specific cells sustain expansion. In vitro and in vivo revealed IFN signaling necessary for mRNA-LNP-induced IL-27 production, failed KO mice, IFNAR1-deficient mice particles also encode restored addition, mRNA-LNPs served as an adjuvant improved cytolytic responses therapeutic efficacy drive anti-pathogen anti-tumor immunity. These highlight central role induced this augment functionality response prophylactic or immunization.

Язык: Английский

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