Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders DOI Open Access
Anyuan Zhang, Qiubai Li, Zhichao Chen

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 225 - 225

Опубликована: Дек. 30, 2024

The global issue of aging populations has become increasingly prominent, thus the research and development for anti-aging therapies to assure longevity as well ameliorate age-related complications is put high on agenda. young humoral milieu been substantiated impart youthful characteristics aged cells or organs. Extracellular vesicles (EVs) are a heterogeneous group cell-derived membrane-limited structures that serve couriers proteins genetic material regulate intercellular communication. Of note, EVs appeared be an indispensable component blood in prolonging lifespans, circulating have indicated mediate beneficial effect aging. Human umbilical cord mesenchymal stem (HUCMSC-EVs), isolated from youngest adult cell source, speculated reproduce function partially revitalize numerous organs old animals. Robust evidence suggested HUCMSC-EVs muti-target therapeutic agents combating alleviating degenerative disorders. Here, we provide comprehensive overview effects brain, heart, vasculature, kidney, muscle, bone, other Furthermore, critically discuss current investigation engineering strategies HUCMSC-EVs, intending unveil their full potential field research.

Язык: Английский

Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders DOI Open Access
Anyuan Zhang, Qiubai Li, Zhichao Chen

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 225 - 225

Опубликована: Дек. 30, 2024

The global issue of aging populations has become increasingly prominent, thus the research and development for anti-aging therapies to assure longevity as well ameliorate age-related complications is put high on agenda. young humoral milieu been substantiated impart youthful characteristics aged cells or organs. Extracellular vesicles (EVs) are a heterogeneous group cell-derived membrane-limited structures that serve couriers proteins genetic material regulate intercellular communication. Of note, EVs appeared be an indispensable component blood in prolonging lifespans, circulating have indicated mediate beneficial effect aging. Human umbilical cord mesenchymal stem (HUCMSC-EVs), isolated from youngest adult cell source, speculated reproduce function partially revitalize numerous organs old animals. Robust evidence suggested HUCMSC-EVs muti-target therapeutic agents combating alleviating degenerative disorders. Here, we provide comprehensive overview effects brain, heart, vasculature, kidney, muscle, bone, other Furthermore, critically discuss current investigation engineering strategies HUCMSC-EVs, intending unveil their full potential field research.

Язык: Английский

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