Implementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial DOI Creative Commons
Menglu Ouyang,

Anila Anjum,

Francisca González

и другие.

PLOS Global Public Health, Год журнала: 2024, Номер 4(12), С. e0003711 - e0003711

Опубликована: Дек. 19, 2024

The third, stepped-wedge, cluster-randomized, Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT3), has shown that a goal-directed multi-faceted incorporating protocols for the management of physiological variables was safe and effective improving functional recovery broad range patients acute intracerebral hemorrhage (ICH). INTERACT3 included time- target-based early intensive lowering systolic blood pressure (SBP, target <140mmHg), glucose control (target 6.1–7.8 mmol/L those without diabetes 7.8–10.0 diabetes), anti-pyrexia treatment body temperature ≤37.5°C), rapid reversal warfarin-related anticoagulation international normalized ratio <1.5). An embedded process evaluation conducted to allow better understanding how implemented different countries enhance transferability this evidence context. This study used mixed-methods approach involving interviews, focus group discussions, surveys evaluate implementation outcomes fidelity, dose, reach, acceptability, appropriateness, adoption, sustainability. Interviews (n = 27), discussions 3), quantitative 48) were 7 low- middle-income (LMICs) 1 high-income country during 2019–2022. generally delivered as planned well accepted by stakeholders, although some difficulties reported reaching SBP glycemic targets. Contextual factors including staff shortage, limited availability antihypertensive drugs, delayed systems care processes, common barriers implementing Bundle. Facilitating good communication collaboration emergency departments, development pathways within available resources, regular training monitoring. Our provides useful insights into contextual which need be addressed scale up global registration : is registered at Clinicaltrials.gov ( NCT03209258 ) Chinese Clinical Registry ChiCTR-IOC-17011787 ).

Язык: Английский

Exploring co-adaptation for public health interventions: insights from a rapid review and interviews DOI Creative Commons
Janneke de Boer, Giuliana Raffaella Longworth, Lea Rahel Delfmann

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 14, 2025

Adapting co-creation research processes and/or public health interventions improves the fit between intervention and population of interest, potentially resulting in more relevant effective interventions. Mode 2 approaches (e.g., co-creation, co-production, co-design, community-based participatory research, action research) can ensure that adaptations socio-cultural economic contexts. However, an overview existing practices how to co-adapt is lacking. This study aimed provide use co-adaptation We conducted a rapid review search on Health CASCADE database. Relevant peer-reviewed studies reporting were identified. A call for case via social media co-authors' snowballing was issued perform interviews with researchers gaining insights into applied from unpublished practice. Interviews analysed using template analysis. Fourteen addressed various issues by co-adapting processes, activities, communication platforms, monitoring strategies, training components, materials' language tone. Most lacked detailed process, though some provided information group composition number, duration, methods applied. Two out 14 used framework (i.e., Intervention Mapping Adapt), seven described their adaptation procedure without naming specific framework, five did not report any procedures or frameworks. Five frameworks ADAPT guidance). process emphasising importance contextual fit, integrating prior knowledge, logging adaptations. first introducing concept exploring It provides details regarding made, whether which used, adapt. The findings highlight need tailored better processes.

Язык: Английский

Процитировано

0
How long does it take to scale-up obesity prevention interventions? DOI Creative Commons
Karen Lee, Adrian Bauman, Luke Wolfenden

и другие.

Preventive Medicine, Год журнала: 2024, Номер 185, С. 108012 - 108012

Опубликована: Май 29, 2024

The scale-up of evidence-based interventions is necessary to reverse high rates obesity. However, doesn't occur frequently nor in a timely manner. While it has been estimated that takes 14-17 years for research translation occur, the time taken prevention largely unknown. This study examined obesity across four pathways.

Язык: Английский

Процитировано

1
Strengths, challenges, and strategies for implementing pragmatic multicenter randomized controlled trials (RCTs): example of the Personalized Citizen Assistance for Social Participation (APIC) trial DOI Creative Commons
Mélanie Levasseur,

Agathe Chaintré-Prieur,

Marie‐France Dubois

и другие.

Trials, Год журнала: 2024, Номер 25(1)

Опубликована: Июнь 27, 2024

Randomized controlled trials (RCTs) are rigorous scientific research designs for evaluating intervention effectiveness. However, implementing RCTs in a real-world context is challenging. To develop strategies to improve its application, it essential understand the strengths and challenges of this design. This study thus aimed explore strengths, challenges, improving implementation pragmatic multicenter, prospective, two-arm RCT effects Personalized Citizen Assistance Social Participation (Accompagnement-citoyen Personnalisé d'Intégration Communautaire: APIC; weekly 3-h personalized stimulation sessions given by trained volunteer over 12-month period) on older adults' health, social participation, life satisfaction.

Язык: Английский

Процитировано

1
Real-world public health interventions demonstrate how research evidence informs program scale-up DOI Creative Commons
Melanie Crane, Karen Lee, Luke Wolfenden

и другие.

Health Promotion International, Год журнала: 2024, Номер 39(5)

Опубликована: Авг. 13, 2024

Evidence-based population interventions rely on intervention testing (efficacy and effectiveness trials) to determine what works improve public health. We investigated the characteristics of real-world health address obesity explored extent which research was undertaken prior scale-up. identified 90 targeting physical activity, nutrition or obesity-related behaviours collected publicly available information their key outcomes. then assessed differences between that followed a pathway those did not. Two-thirds (n = 60) were reported as having pathway. Univariate logistic regression analysis revealed these more likely be education [odds ratio (OR): 5.56; 95% confidence interval (CI): 1.38-22.38], developed by institutes (OR: 12.81; CI: 3.47-47.34), delivered in North America 4.13; 1.61-10.62), less owned 0.35; 0.14-0.88) funded government organizations 0.37; 0.14-0.95). Interventions nearly three times have positive impact 2.72; 1.04-7.14). scale-up no sustained longer than Differences exist across follow population-scale delivery do not, regarding organizational environmental context. A benefit is it has

Язык: Английский

Процитировано

1
Implementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial DOI Creative Commons
Menglu Ouyang,

Anila Anjum,

Francisca González

и другие.

PLOS Global Public Health, Год журнала: 2024, Номер 4(12), С. e0003711 - e0003711

Опубликована: Дек. 19, 2024

The third, stepped-wedge, cluster-randomized, Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT3), has shown that a goal-directed multi-faceted incorporating protocols for the management of physiological variables was safe and effective improving functional recovery broad range patients acute intracerebral hemorrhage (ICH). INTERACT3 included time- target-based early intensive lowering systolic blood pressure (SBP, target <140mmHg), glucose control (target 6.1–7.8 mmol/L those without diabetes 7.8–10.0 diabetes), anti-pyrexia treatment body temperature ≤37.5°C), rapid reversal warfarin-related anticoagulation international normalized ratio <1.5). An embedded process evaluation conducted to allow better understanding how implemented different countries enhance transferability this evidence context. This study used mixed-methods approach involving interviews, focus group discussions, surveys evaluate implementation outcomes fidelity, dose, reach, acceptability, appropriateness, adoption, sustainability. Interviews (n = 27), discussions 3), quantitative 48) were 7 low- middle-income (LMICs) 1 high-income country during 2019–2022. generally delivered as planned well accepted by stakeholders, although some difficulties reported reaching SBP glycemic targets. Contextual factors including staff shortage, limited availability antihypertensive drugs, delayed systems care processes, common barriers implementing Bundle. Facilitating good communication collaboration emergency departments, development pathways within available resources, regular training monitoring. Our provides useful insights into contextual which need be addressed scale up global registration : is registered at Clinicaltrials.gov ( NCT03209258 ) Chinese Clinical Registry ChiCTR-IOC-17011787 ).

Язык: Английский

Процитировано

0