Regulation and targeting of SREBP-1 in hepatocellular carcinoma

Cancer and Metastasis Reviews, Год журнала: 2023, Номер 43(2), С. 673 - 708

Опубликована: Дек. 1, 2023

Abstract Hepatocellular carcinoma (HCC) is an increasing burden on global public health and associated with enhanced lipogenesis, fatty acid uptake, lipid metabolic reprogramming. De novo lipogenesis under the control of transcription factor sterol regulatory element-binding protein 1 (SREBP-1) essentially contributes to HCC progression. Here, we summarize current knowledge regulation SREBP-1 isoforms in based cellular, animal, clinical data. Specifically, (i) address overarching mechanisms for regulating transcription, proteolytic processing, nuclear stability, transactivation (ii) critically discuss their impact HCC, taking into account (iii) insights from pharmacological approaches. Emphasis placed cross-talk phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt)-mechanistic target rapamycin (mTOR) axis, AMP-activated (AMPK), A (PKA), other kinases that directly phosphorylate SREBP-1; factors, such as liver X receptor (LXR), peroxisome proliferator-activated receptors (PPARs), γ co-activator (PGC-1), signal transducers activators (STATs), Myc; epigenetic mechanisms; post-translational modifications SREBP-1-regulatory metabolites oxysterols polyunsaturated acids. By carefully scrutinizing role development, progression, metastasis, therapy resistance, shed light potential SREBP-1-targeting strategies prevention treatment.

Язык: Английский

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Efficient ultrasound-mediated drug delivery to orthotopic liver tumors – Direct comparison of doxorubicin-loaded nanobubbles and microbubbles

Journal of Controlled Release, Год журнала: 2024, Номер 367, С. 135 - 147

Опубликована: Янв. 25, 2024

Язык: Английский

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Tamarind seed gum-based hydrogel for the targeted delivery of imidazobenzothiazole sulfonamide derivative as an anticancer agent

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 295, С. 139665 - 139665

Опубликована: Янв. 8, 2025

Язык: Английский

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Global research trends and emerging hotspots in nano-drug delivery systems for lung cancer: a comprehensive bibliometric analysis (1998–2024)

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 11, 2025

Nano-drug delivery systems (NDDS) have become a promising alternative and adjunctive strategy for lung cancer (LC) treatment. However, comprehensive bibliometric analyses examining global research efforts on NDDS in LC are scarce. This study aims to fill this gap by identifying key trends, emerging hotspots, collaboration networks within the field of LC. A total 2452 publications, spanning from 1998 2024, were extracted Web Science Core Collection. The data analyzed using tools such as VOSviewer, CiteSpace, R package 'bibliometrix'. analysis covered contributions 12,539 researchers affiliated with 2689 institutions across 55 countries, their work published 551 different journals. Research output has increased steadily, China United States leading both publication volume impact. Major contributors include Chinese Academy Sciences Shanghai Jiao Tong University. International Journal Nanomedicine most articles, while Controlled Release ranked highest co-citations. Kamal Dua authored papers, Maeda, H. was frequently co-cited author. Key areas encompass "active targeting", "drug optimization", "overcoming drug resistance", "nanocarriers", "pulmonary delivery". Emerging hotspots "epithelial mesenchymal transition", "mucus penetration", "lipid nanoparticles", "hydrogels", "immune checkpoint inhibitors". analysis, first LC, identifies targeting" nanoparticles" These findings provide essential insights guide future optimize treatment strategies.

Язык: Английский

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Recent advances in polymeric nanoparticles for the treatment of hepatic diseases

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Янв. 24, 2025

The liver performs crucial roles in energy metabolism, detoxification, and immune regulation. Hepatic diseases, including hepatitis, fibrosis, cancer, have posed a significant threat to global health, emphasizing the critical need for development of novel effective treatment approaches. Nanotechnology, an emerging technology, has been extensively researched medicine. Among many types nanomaterials, polymeric nanoparticles (NPs) are widely used drug delivery systems. Compared traditional therapies, they offer advantages disease by improving outcomes reducing side effects. This review introduced discussed application natural polymers synthetic their management. Furthermore, this paper reviewed -mainly chitosan (CS), hyaluronic acid (HA), polyethylene glycol (PEG) poly (lactic-co-glycolic acid) (PLGA)-in treatment, focusing on use various systems pure bioactive compounds origin, drugs, nucleic acids, peptides, others. Finally, challenges future perspectives NPs were provide guidance further research directions, with aim promoting clinical nanotherapeutics treating hepatic diseases.

Язык: Английский

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Cerium oxide decorated 5-fluorouracil loaded chitosan nanoparticles for treatment of hepatocellular carcinoma

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 216, С. 52 - 64

Опубликована: Июнь 22, 2022

Язык: Английский

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Combination of micelles and liposomes as a promising drug delivery system: a review

Drug Delivery and Translational Research, Год журнала: 2023, Номер 13(11), С. 2767 - 2789

Опубликована: Июнь 6, 2023

Язык: Английский

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Wireless sequential dual light delivery for programmed PDT in vivo

Light Science & Applications, Год журнала: 2024, Номер 13(1)

Опубликована: Май 15, 2024

Abstract Using photodynamic therapy (PDT) to treat deep-seated cancers is limited due inefficient delivery of photosensitizers and low tissue penetration light. Polymeric nanocarriers are widely used for photosensitizer delivery, while the self-quenching encapsulated would impair PDT efficacy. Furthermore, generated short-lived reactive oxygen spieces (ROS) can hardly diffuse out nanocarriers, resulting in Therefore, a smart nanocarrier system which be degraded by light, followed activation potentially overcome these limitations enhance A light-sensitive polymer encapsulating (RB-M) was synthesized. An implantable wireless dual wavelength microLED device delivers two light wavelengths sequentially developed programmatically control release loaded photosensitizer. Two transmitter coils with matching resonant frequencies allow connected LEDs emit different independently. Optimal irradiation time, dose, RB-M concentration were determined using an agent-based digital simulation method. In vitro vivo validation experiments orthotopic rat liver hepatocellular carcinoma disease model confirmed that rupture sequential dose strategy resulted successful at reduced clinically significant event enhances treatment safety.

Язык: Английский

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Hepatic artery infusion chemotherapy: A resurgence

World Journal of Gastrointestinal Oncology, Год журнала: 2025, Номер 17(2)

Опубликована: Янв. 18, 2025

In this manuscript, we comment on the article by Zhou et al, who assessed efficacy of hepatic arterial infusion chemotherapy (HAIC) and its combination strategies for advanced hepatocellular carcinoma (HCC) using network meta-analysis methodology. We focus specifically potential advantages role HAIC in treatment algorithm HCC. However, there remains numerous knowledge gaps before can be established. There is significant heterogeneity regimes with difficult interpretation clinical outcomes. Additionally, a lack direct comparative data between HAIC, systemic chemotherapy, novel immunotherapies targeted therapies. The underlying biochemical mechanisms that might explain effect HCC microenvironment requires further research. developing era nanotechnology drug delivery systems, integration technologies to effectively treat whilst minimising complications.

Язык: Английский

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Targeted delivery of curcumin and CM11 peptide against hepatocellular carcinoma cells based on binding affinity of PreS1-coated chitosan nanoparticles to SB3 protein

Amino Acids, Год журнала: 2025, Номер 57(1)

Опубликована: Янв. 25, 2025

In recent years, the use of cationic peptides as alternative drugs with anticancer activity has received attention. this study, targeted release curcumin (Cur) and CM11 peptide alone together against hepatocellular carcinoma (HCC) was evaluated using chitosan nanoparticles (CS NPs) coated Pres1 that target SB3 antigen HCC cells (PreS1-Cur-CM11-CS NPs). protein is specific PreS1 a part hepatitis B antigen, which can specifically bind to protein. Chitosan used prepare NPs. To Cur loading, were added CS solution in appropriate concentrations. coupled surface NPs EDC catalyst HepG2 cells. SEM DLS analysis confirmed PreS1-Cur-CM11-CS had size about 132 nm, ideal for penetrating cell membrane. The loading equal 87% 65%, respectively, sustained better acidic environment than physiological environment. MTT assay showed act manner highest toxicity on compared control by decrease viability 26% after 48 h based apoptosis. results are capable drug cancer have significant potential fight cancer.

Язык: Английский

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