ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
As
we
progress
into
the
21st
century,
cancer
stands
as
one
of
most
dreaded
diseases.
With
approximately
in
every
four
individuals
facing
a
lifetime
risk
developing
cancer,
remains
serious
health
challenges
worldwide.
Its
multifaceted
nature
makes
it
an
arduous
and
tricky
problem
to
diagnose
treat.
Over
years,
researchers
have
explored
plenty
approaches
avenues
improve
management.
One
notable
strategy
includes
study
extracellular
vesicles
(EVs)
potential
biomarkers
therapeutics.
Among
these
EVs,
exosomes
emerged
particularly
promising
candidates
due
their
unique
characteristic
properties
functions.
They
are
small
membrane-bound
secreted
by
cells
carrying
cargo
biomolecules
such
proteins,
nucleic
acids,
lipids.
These
play
crucial
roles
intercellular
communication,
facilitating
transfer
biological
information
between
cell-to-cell
communication.
Exosomes
transport
cargoes
DNA,
RNA,
lipids
involved
cellular
reprogramming
promoting
cancer.
In
this
review,
explore
molecular
composition
exosomes,
significance
chemistry
development,
its
theranostic
application
well
research
complications
solutions.
Biotechnology for Biofuels and Bioproducts,
Год журнала:
2024,
Номер
17(1)
Опубликована: Янв. 28, 2024
Abstract
Background
Microalgae-derived
extracellular
vesicles
(EVs),
which
transfer
their
cargos
to
the
environment
affect
recipient
cells,
play
important
roles
in
microalgal
growth
and
environmental
adaptation.
And,
they
are
also
considered
as
sustainable
renewable
bioresources
of
delivery
nanocarrier
for
bioactive
molecules
and/or
artificial
drug
molecules.
However,
molecular
composition
functions
remain
poorly
understood.
Results
In
this
study,
isolation,
characterization,
functional
verification
Haematococcus
pluvialis
-derived
EVs
(HpEVs)
were
performed.
The
results
indicated
that
HpEVs
with
typical
EV
morphology
size
secreted
by
H.
cells
during
whole
period
accumulated
culture
medium.
Cellular
uptake
was
confirmed,
regulation
various
physiological
processes
characterized.
short-term
inhibition
HpEV
secretion
accumulation
cellular
components
HpEVs,
thereby
altering
biological
response
these
at
level.
Meanwhile,
continuously
inhibiting
negatively
influenced
growth,
fatty
acid
astaxanthin
.
Small
RNA
high-throughput
sequencing
further
performed
determine
miRNA
cargoes
compelling
details
depth.
Comparative
analysis
revealed
commonalities
differences
species
expression
levels
three
stages
HpEVs.
A
total
163
mature
miRNAs
identified
a
few
unique
reveal
highest
levels,
profile
exhibited
clear
stage-specific
pattern.
Moreover,
12
differentially
expressed
target
genes
classified
cell
cycle
control,
lipid
transport
metabolism,
secondary
metabolites
biosynthesis
so
on.
Conclusion
It
therefore
proposed
including
constituents,
suggested
potential
modulate
state
To
summarize,
work
uncovers
intercellular
communication
metabolism
Materials Advances,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
pursuit
of
effective
drug
delivery
systems
is
critical
in
advancing
cancer
therapies,
particularly
the
realms
chemotherapy,
radiotherapy
and
immunotherapy.
Aim
This
study
aims
to
explore
a
sustainable
and
scalable
approach
using
tomato
fruit-derived
sEVs
(TsEVs)
deliver
calcitriol
for
enhanced
anticancer
effects,
addressing
challenges
of
low
yield
high
costs
associated
with
mammalian
cell-derived
sEVs.
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(3), С. 144 - 144
Опубликована: Фев. 22, 2025
Exosome-like
nanovesicles
(ELNs)
derived
from
natural
products
are
gaining
attention
as
innovative
therapeutic
agents
due
to
their
biocompatibility,
low
immunogenicity,
and
capability
transport
bioactive
molecules
such
proteins,
lipids,
nucleic
acids.
These
plant-derived
ELNs
exhibit
structural
similarities
with
mammalian
exosomes,
making
them
suitable
for
drug
delivery,
microbiome-targeted
therapies,
regenerative
medicine.
Recent
studies
highlight
potential
in
treating
cancer,
inflammation,
metabolic
disorders.
Additionally,
have
applications
cosmetics,
agriculture,
the
food
industry.
This
review
combines
latest
advancements
research
on
ELNs,
focusing
isolation
techniques,
pharmacological
effects,
applications.
Although
offer
promising
opportunities,
several
challenges
must
be
addressed,
including
standardization,
large-scale
production,
vivo
efficacy.
By
summarizing
cutting-edge
suggesting
future
directions,
we
aim
inspire
further
development
of
next-generation
platforms.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
As
we
progress
into
the
21st
century,
cancer
stands
as
one
of
most
dreaded
diseases.
With
approximately
in
every
four
individuals
facing
a
lifetime
risk
developing
cancer,
remains
serious
health
challenges
worldwide.
Its
multifaceted
nature
makes
it
an
arduous
and
tricky
problem
to
diagnose
treat.
Over
years,
researchers
have
explored
plenty
approaches
avenues
improve
management.
One
notable
strategy
includes
study
extracellular
vesicles
(EVs)
potential
biomarkers
therapeutics.
Among
these
EVs,
exosomes
emerged
particularly
promising
candidates
due
their
unique
characteristic
properties
functions.
They
are
small
membrane-bound
secreted
by
cells
carrying
cargo
biomolecules
such
proteins,
nucleic
acids,
lipids.
These
play
crucial
roles
intercellular
communication,
facilitating
transfer
biological
information
between
cell-to-cell
communication.
Exosomes
transport
cargoes
DNA,
RNA,
lipids
involved
cellular
reprogramming
promoting
cancer.
In
this
review,
explore
molecular
composition
exosomes,
significance
chemistry
development,
its
theranostic
application
well
research
complications
solutions.
