Differences in the prevalence of allergy and asthma among US children and adolescents during and before the COVID-19 pandemic DOI Creative Commons

Yingyu Liang,

Qian Li, Man Wang

и другие.

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 6, 2024

The increasing prevalence of allergies and asthma has led to a growing global socioeconomic burden. Since the outbreak COVID-19 pandemic, health lifestyles children adolescents have changed dramatically. It's unclear how this shift impacted allergy asthma, with limited studies addressing question. We aim explore difference among US during before pandemic using nationally representative sample adolescents. This cross-sectional study included 31,503 participants in National Health Interview Survey (NHIS) between 2018 2021. Allergies were defined on an affirmative response questionnaire by parent or guardian. Chi-square tests used compare baseline characteristics for categorical variables. Differences estimated weighted logistic regression, adjusting demographic factors. Interaction analyses explored variations across strata. In aged 0 17, any was 26.1% (95% CI, 24.8%- 27.4%) 27.1% 25.9%- 28.2%) Thereinto, 2018, respiratory allergies, food skin 14.0% 13.1%- 15.0%), 6.5% 5.8%- 7.1%) 12.6% 11.6%- 13.5%), respectively, 2021, 18.8% 17.8%- 19.9%), 5.8% 5.2%- 6.4%) 10.7% 9.9%- 11.5%), respectively. And 11.1% 10.5%- 11.7%) 2018–2019 9.8% 9.2%- 10.4%) 2020–2021. Prevalence had statistically significant differences. differences persisted after increased both decreased compared pre-COVID-19 pandemic. Further research is required association allergic diseases particular emphasis impact lifestyle changes resulting from measures prevent infection.

Язык: Английский

T Lymphocyte Characteristic Changes Under Serum Cytokine Deviations and Prognostic Factors of COVID-19 in Pregnant Women DOI

Ehsan Aminsobahni,

Maryam Hosseini, Nasim Gholizadeh

и другие.

Applied Biochemistry and Biotechnology, Год журнала: 2023, Номер 196(7), С. 4366 - 4381

Опубликована: Ноя. 10, 2023

Язык: Английский

Процитировано

2

Changes in RNA dynamics in the course of hypoxia in myeloid cells DOI Creative Commons
Rebekka Bauer

Опубликована: Янв. 1, 2024

Molecular oxygen (O2) is essential for numerous metabolic processes. Not surprisingly, hypoxia and the resulting adaptations play a pivotal role in pathophysiology, e.g., cancer or inflammatory diseases. Of note, myeloid cells are known to accumulate hypoxic regions such as tumor cores rheumatoid arthritis joints may contribute disease progression. While most studies so far concentrated on transcriptional adaptation by hypoxia-inducible factors (HIF) 1 2 under short term hypoxia, prolonged deprivation alternative post-transcriptional regulation rather poorly investigated. Consequently, aim of study was generate comprehensive overview mRNA de novo synthesis degradation its contribution total changes monocytic course hypoxia. To this end, I used thiol-linked alkylation sequencing RNA (SLAM-Seq) characterize dynamics Specifically, labeled THP-1 normoxia (N), acute (AH; 8 h 1% O2), chronic (CH; 72 O2) with 4-thiouridine (4sU), which allows transcriptome-wide identification synthesized mRNAs estimation their half-lives. Total expression analyses revealed that occurred CH. Considering HIF accumulation shown decline again CH, further analyzed impact stability gene expression. observed global reduction half-lives indicative attenuation energy-consuming protein upon deprivation. Moreover, subgroup destabilized transcripts decreased consisted 59 nuclear-encoded mitochondrial mRNAs. This might prevent futile production new mitochondria conditions, where even actively degraded detrimental reactive species. stability-regulated were mainly vast majority differentially upregulated. Functional not only but also cholesterol homeostasis response top enriched terms, corroborating findings level. Focusing hypoxia-altered metabolism, an 9 early decrease late precursors, separated several oxygen-dependent enzymatic steps. Although levels slightly reduced, my data indicate locally lowered endoplasmic reticulum (ER) cause feedback activation ER cholesterol-sensing transcription factor sterol regulatory element-binding (SREBP2) induction biosynthesis enzymes. Interestingly, broad range interferon-stimulated genes (ISGs), antiviral function, induced similar kinetics SREBP2 targets, suggesting immunometabolic crosstalk. availability certain intermediates well direct involvement seemed unlikely ISG induction, intracellular distribution appeared crucial chemokine-ISGs. Mechanistically, found MyD88-dependent toll-like receptor 4 (TLR4) signaling contributes enhanced likely sensitized dynamics. Importantly, amplified chemokine-ISGs monocytes treatment severe respiratory syndrome coronavirus type (SARS-CoV-2) spike via TLR4 similarly after addition infectious virus, systemic inflammation hypoxemic patients disease-2019 (COVID-19). Taken together, comprehensively monocytes. identified modulating mechanism limit oxygen-restricted conditions. characterized crosstalk between disturbed spontaneous interferon (IFN)-signaling monocytes, cases COVID-19.

Язык: Английский

Процитировано

0

INTERSEÇÃO VIRAL: ANÁLISE DOS EFEITOS NEUROLÓGICOS PÓS-COVID NO SISTEMA NERVOSO DOI Open Access
Aléxia Stefani Siqueira Zetum,

Danielle Ribeiro Campos da Silva,

Giulia Maria Giacinti

и другие.

Опубликована: Март 5, 2024

Процитировано

0

OS EFEITOS DA CL EM OUTROS SISTEMAS CORPORAIS DOI Open Access
Giulia Maria Giacinti, Aléxia Stefani Siqueira Zetum, Flávio dos Santos Alvarenga

и другие.

Опубликована: Март 5, 2024

Процитировано

0

INTRODUÇÃO DOI Open Access
Aléxia Stefani Siqueira Zetum,

Giulia Maria Giacinti,

Felipe Ataides Mion

и другие.

Опубликована: Март 5, 2024

Процитировано

0

COVID-19 E O SISTEMA IMUNOLÓGICO DOI Open Access
Aléxia Stefani Siqueira Zetum,

Giulia Maria Giacinti,

Yasmin Moreto Guaitolini

и другие.

Опубликована: Март 5, 2024

Процитировано

0

EFEITOS DA COVID LONGA NO SISTEMA CARDIORRESPIRATÓRIO DOI Open Access

Vinícius do Prado Ventorim,

Giulia Maria Giacinti,

Aléxia Stefani Siqueira Zetum

и другие.

Опубликована: Март 5, 2024

Процитировано

0

Além da pandemia: desvendando a covid longa e suas múltiplas facetas DOI Open Access
Elizeu Fagundes de Carvalho, Sônia Groisman, Iúri Drumond Louro

и другие.

Опубликована: Март 5, 2024

Процитировано

0

QUALIDADE DE VIDA PÓS-PANDEMIA: AVALIANDO IMPACTOS E RECUPERANDO O BEM-ESTAR DOI Open Access

Livia Cesar Morais,

Henrique Perini Rosa,

Aléxia Stefani Siqueira Zetum

и другие.

Опубликована: Март 5, 2024

Процитировано

0

Evaluation of changes in exhausted T lymphocytes and miRNAs expression in the different trimesters of pregnancy in pregnant women DOI

Ali Akbar Shekarchi,

Leila Hosseini,

Amin Kamrani

и другие.

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Март 23, 2024

Язык: Английский

Процитировано

0