Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Янв. 24, 2023
In
the
last
few
decades,
practical
use
of
stem
cells
(SCs)
in
clinic
has
attracted
significant
attention
regenerative
medicine
due
to
ability
these
proliferate
and
differentiate
into
other
cell
types.
However,
recent
findings
have
demonstrated
that
therapeutic
capacity
SCs
may
also
be
mediated
by
their
secrete
biologically
active
factors,
including
extracellular
vesicles
(EVs).
Such
submicron
circular
membrane-enveloped
released
from
surface
harbour
bioactive
cargo
form
proteins,
lipids,
mRNA,
miRNA,
regulatory
factors.
Notably,
growing
evidence
indicated
EVs
transfer
content
recipient
greatly
modulate
functional
fate.
Thus,
they
been
recently
envisioned
as
a
new
class
paracrine
factors
cell-to-cell
communication.
Importantly,
activity
immune
system,
playing
an
important
role
regulation
inflammation,
exhibiting
broad
spectrum
immunomodulatory
promotes
transition
pro-inflammatory
pro-regenerative
environment
site
tissue
injury.
Consequently,
interest
is
placed
on
attempts
utilize
clinical
applications
inflammatory-related
dysfunctions
potential
next-generation
alternative
cell-based
approaches.
this
review
we
will
discuss
current
knowledge
biological
properties
SC-derived
EVs,
with
special
focus
inflammatory
response.
We
address
several
disease
models,
vitro
vivo
preclinical,
well
studies.
Finally,
highlight
perspectives
future
challenges
emerging
EV-based
strategies
inflammation-related
diseases
treatment.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Янв. 12, 2024
Abstract
Although
stem
cell-based
therapy
has
demonstrated
considerable
potential
to
manage
certain
diseases
more
successfully
than
conventional
surgery,
it
nevertheless
comes
with
inescapable
drawbacks
that
might
limit
its
clinical
translation.
Compared
cells,
cell-derived
exosomes
possess
numerous
advantages,
such
as
non-immunogenicity,
non-infusion
toxicity,
easy
access,
effortless
preservation,
and
freedom
from
tumorigenic
ethical
issues.
Exosomes
can
inherit
similar
therapeutic
effects
their
parental
cells
embryonic
adult
through
vertical
delivery
of
pluripotency
or
multipotency.
After
a
thorough
search
meticulous
dissection
relevant
literature
the
last
five
years,
we
present
this
comprehensive,
up-to-date,
specialty-specific
disease-oriented
review
highlight
surgical
application
exosomes.
derived
(e.g.,
embryonic,
induced
pluripotent,
hematopoietic,
mesenchymal,
neural,
endothelial
cells)
are
capable
treating
encountered
in
orthopedic
neurosurgery,
plastic
general
cardiothoracic
urology,
head
neck
ophthalmology,
obstetrics
gynecology.
The
diverse
cells-derived
hierarchical
translation
tissue-specific
responses,
cell-specific
molecular
signaling
pathways.
In
review,
viable
potent
alternative
managing
various
conditions.
We
recommend
future
research
combines
wisdoms
surgeons,
nanomedicine
practitioners,
cell
researchers
intriguing
area.
Cell Communication and Signaling,
Год журнала:
2023,
Номер
21(1)
Опубликована: Апрель 13, 2023
Abstract
Extracellular
vesicles
(EVs)
are
small,
membrane-bound
structures
that
released
from
cells
into
the
surrounding
environment.
These
can
be
categorized
as
exosomes,
microvesicles,
or
apoptotic
vesicles,
and
they
play
an
essential
role
in
intercellular
communication.
attracting
significant
clinical
interest
offer
potential
for
drug
delivery,
disease
diagnosis,
therapeutic
intervention.
To
fully
understand
regulation
of
communication
through
EVs,
it
is
to
investigate
underlying
mechanisms.
This
review
aims
provide
a
summary
current
knowledge
on
communications
involved
EV
targeting,
binding,
uptake,
well
factors
influence
these
interactions.
include
properties
cellular
environment,
recipient
cell.
As
field
EV-related
continues
expand
techniques
improve,
we
expect
uncover
more
information
about
this
complex
area,
despite
limitations
our
knowledge.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(4), С. 571 - 571
Опубликована: Апрель 10, 2023
Drug
delivery
to
the
central
nervous
system
(CNS)
is
limited
due
presence
of
blood–brain
barrier
(BBB),
a
selective
physiological
located
at
brain
microvessels
that
regulates
flow
cells,
molecules
and
ions
between
blood
brain.
Exosomes
are
nanosized
extracellular
vesicles
expressed
by
all
cell
types
function
as
cargos,
allowing
for
communication
cells.
The
exosomes
were
shown
cross
or
regulate
BBB
in
healthy
disease
conditions.
However,
mechanistic
pathways
which
have
not
been
fully
elucidated
yet.
In
this
review,
we
explore
transport
mechanisms
through
BBB.
A
large
body
evidence
suggests
exosome
occurs
primarily
transcytosis.
transcytosis
influenced
several
regulators.
Inflammation
metastasis
also
enhance
trafficking
across
We
shed
light
on
therapeutical
applications
treating
diseases.
Further
investigations
essential
provide
clearer
insights
related
treatment.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115087 - 115087
Опубликована: Июнь 29, 2023
All
forms
of
life
produce
nanosized
extracellular
vesicles
called
exosomes,
which
are
enclosed
in
lipid
bilayer
membranes.
Exosomes
engage
cell-to-cell
communication
and
participate
a
variety
physiological
pathological
processes.
function
via
their
bioactive
components,
delivered
to
target
cells
the
form
proteins,
nucleic
acids,
lipids.
as
drug
delivery
vehicles
due
unique
properties
innate
stability,
low
immunogenicity,
biocompatibility,
biodistribution,
accumulation
desired
tissues,
toxicity
normal
stimulation
anti-cancer
immune
responses,
penetration
capacity
into
distance
organs.
mediate
cellular
communications
by
delivering
various
molecules
including
oncogenes,
oncomiRs,
specific
DNA,
messenger
RNA
(mRNA),
microRNA
(miRNA),
small
interfering
(siRNA),
circular
(circRNA).
These
substances
can
be
transferred
change
transcriptome
influence
tumor-related
signaling
pathways.
After
considering
all
available
literature,
this
review
we
discuss
biogenesis,
composition,
production,
purification
exosomes.
We
briefly
exosome
isolation
techniques.
explore
great-length
exosomes
mechanism
for
substances,
chemicals,
chemotherapeutic
drugs.
also
talk
about
benefits
drawbacks
This
concludes
with
discussion
future
perspective
challenges.
hope
that
will
provide
us
better
understanding
current
state
nanomedicine
applications
biomedicine.
Frontiers in Immunology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 19, 2023
Exosomes
are
membranous
vesicles
actively
secreted
by
almost
all
cells
and
they
deliver
certain
intracellular
molecules,
including
nucleic
acids,
proteins,
lipids,
to
target
cells.
They
also
considered
be
good
carriers
for
drug
delivery
due
their
biocompatibility,
high
permeability,
low
immunogenicity,
toxicity.
from
immune
were
reported
have
immunomodulatory
activities.
Herein
we
evaluated
the
application
of
exosomes
derived
expanded
natural
killer
(eNK-EXO)
treatment
ovarian
cancer
(OC).
We
demonstrate
that
eNK-EXO
express
typical
protein
markers
(NK)
cells,
can
preferentially
uptaken
SKOV3
display
cytotoxicity
against
OC
Furthermore,
loaded
with
cisplatin
could
sensitize
drug-resistant
anti-proliferation
effect
cisplatin.
In
addition,
show
activate
NK
immunosuppressive
tumor
microenvironment,
mechanism
which
is
explored
transcriptional
analysis.
summary,
exhibit
anti-tumor
activity
on
its
own,
used
enhance
cytotoxic
reverse
immunosuppression
may
lead
great
prospect
using
in
clinic.
Our
work
builds
a
strong
foundation
further
evaluation
other
solid
therapies.
Journal of Controlled Release,
Год журнала:
2023,
Номер
356, С. 463 - 480
Опубликована: Март 15, 2023
Complexity
and
difficulties
in
wound
management
are
pressing
concerns
that
affect
patients'
quality
of
life
may
result
tissue
infection,
necrosis,
loss
local
systemic
functions.
Hence,
novel
approaches
to
accelerate
healing
being
actively
explored
over
the
last
decade.
Exosomes
as
important
mediators
intercellular
communications
promising
natural
nanocarriers
due
their
biocompatibility,
low
immunogenicity,
drug
loading
targeting
capacities,
innate
stability.
More
importantly,
exosomes
developed
a
versatile
pharmaceutical
engineering
platform
for
repair.
This
review
provides
an
overview
biological
physiological
functions
derived
from
variety
origins
during
phases,
strategies
exosomal
engineering,
therapeutic
applications
skin
regeneration.
Biomedicines,
Год журнала:
2023,
Номер
11(4), С. 1053 - 1053
Опубликована: Март 29, 2023
Plant-derived
exosome-like
nanoparticles
(PDENs)
comprise
various
bioactive
biomolecules.
As
an
alternative
cell-free
therapeutic
approach,
they
have
the
potential
to
deliver
nano-bioactive
compounds
human
body,
and
thus
lead
anti-inflammatory,
antioxidant,
anti-tumor
benefits.
Moreover,
it
is
known
that
Indonesia
one
of
herbal
centers
world,
with
abundance
unexplored
sources
PDENs.
This
encouraged
further
research
in
biomedical
science
develop
natural
richness
plants
as
a
source
for
welfare.
study
aims
verify
PDENs
purposes,
especially
regenerative
therapy
applications,
by
collecting
analyzing
data
from
latest
relevant
developments.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3888 - 3888
Опубликована: Фев. 15, 2023
Adipose-derived
mesenchymal
stromal
cells
(AD-MSCs)
have
been
extensively
studied
in
recent
years.
Their
attractiveness
is
due
to
the
ease
of
obtaining
clinical
material
(fat
tissue,
lipoaspirate)
and
relatively
large
number
AD-MSCs
present
adipose
tissue.
In
addition,
possess
a
high
regenerative
potential
immunomodulatory
activities.
Therefore,
great
stem
cell-based
therapies
wound
healing
as
well
orthopedic,
cardiovascular,
or
autoimmune
diseases.
There
are
many
ongoing
trials
on
AD-MSC
cases
their
effectiveness
has
proven.
this
article,
we
current
knowledge
about
based
our
experience
other
authors.
We
also
demonstrate
application
selected
pre-clinical
models
studies.
can
be
pillar
next
generation
that
will
chemically
genetically
modified.
Despite
much
research
these
cells,
there
still
important
interesting
areas
explore.
