Molecular Therapy — Methods & Clinical Development, Год журнала: 2024, Номер 32(3), С. 101279 - 101279
Опубликована: Июнь 6, 2024
Язык: Английский
Cryobiology, Год журнала: 2024, Номер 115, С. 104856 - 104856
Опубликована: Фев. 8, 2024
Mesenchymal stromal cells (MSCs) have become one of the most investigated and applied for cellular therapy regenerative medicine. In this update our review published in 2015, we show that studies continue to abound regarding characterization MSCs distinguish them from other similar cell types, discovery new tissue sources MSCs, confirmation their properties functions render suitable as a therapeutic. Because cryopreservation is widely recognized only technology would enable on-demand availability here although traditional method cryopreserving by slow cooling presence 10% dimethyl sulfoxide (Me2SO) continues be used many, several novel MSC approaches emerged. As previous review, conclude these recent reports viable functional diverse tissues can recovered after using variety cryoprotectants, freezing protocols, storage temperatures, periods storage. We also logistical reasons there are now more devoted which derived. A topic included covers application COVID-19 arising immunomodulatory antiviral properties. Due inherent heterogeneity populations different still no standardized procedure isolation, identification, characterization, cryopreservation, route administration, not likely "one-size-fits-all" approach applications cell-based
Язык: Английский
Процитировано
4
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 243 - 273
Опубликована: Янв. 1, 2025
Процитировано
0
Cells, Год журнала: 2024, Номер 13(7), С. 617 - 617
Опубликована: Апрель 2, 2024
Glioblastoma is the most aggressive, malignant, and lethal brain tumor of central nervous system. Its poor prognosis lies in its inefficient response to currently available treatments that consist surgical resection, radiotherapy, chemotherapy. Recently, use mesenchymal stem cells (MSCs) as a possible kind cell therapy against glioblastoma gaining great interest due their immunomodulatory properties, tropism, differentiation into other types. However, MSCs seem present both antitumor pro-tumor properties depending on tissue from which they come. In this work, possibility using deliver therapeutic genes, oncolytic viruses, miRNA presented, well strategies can improve efficacy glioblastoma, such CAR-T cells, nanoparticles, exosomes.
Язык: Английский
Процитировано
2
Stem Cells Translational Medicine, Год журнала: 2024, Номер 13(8), С. 738 - 749
Опубликована: Июнь 12, 2024
Abstract Oncolytic adenoviruses have emerged as a promising therapeutic approach for cancer therapy. However, systemic delivery of the viruses to metastatic tumors remains major challenge. Mesenchymal stem cells (MSCs) possess tumor tropism property and can be used cellular vehicles delivering oncolytic sites. Since telomerase activity is found in ~90% human carcinomas, but undetected normal adult cells, reverse transcriptase gene (TERT) promoter exploited regulating replication adenoviruses. Here, we evaluated antitumor effects syngeneic murine MSCs loaded with luciferase-expressing, telomerase-dependent adenovirus Ad.GS2 (MSC-Ad.GS2) alone on MBT-2 bladder tumors. supported low degree replication, which could augmented by coculture or tumor-conditioned medium (TCM), suggesting that viral increased when MSC-Ad.GS2 migrates TCM enhanced Ad.GS2-infected MSCs. SDF-1 cell homing factor. Our results suggest SDF-1/STAT3/TERT signaling axis response microenvironment may contribute carried Notably, demonstrate potent efficacy systemically delivered pleural disseminated experimental metastasis models using intrapleural tail vein injection respectively. Treatment significantly reduced growth prolonged survival mice bearing expressed broad spectrum cancers, this strategy broadly applicable.
Язык: Английский
Процитировано
2
Virology, Год журнала: 2024, Номер 598, С. 110196 - 110196
Опубликована: Июль 31, 2024
Язык: Английский
Процитировано
2
Molecular Therapy — Methods & Clinical Development, Год журнала: 2024, Номер 32(3), С. 101279 - 101279
Опубликована: Июнь 6, 2024
Язык: Английский
Процитировано
0