Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1518 - 1518
Опубликована: Дек. 12, 2024
Oxidative
stress
plays
a
critical
role
in
various
physiological
and
pathological
processes,
particularly
during
pregnancy,
where
it
can
significantly
affect
maternal
fetal
health.
In
the
context
of
viral
infections,
such
as
those
caused
by
Human
Immunodeficiency
Virus
(HIV)
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
oxidative
may
exacerbate
complications
disrupting
cellular
function
immune
responses.
Antiviral
drugs,
while
essential
managing
these
also
contribute
to
stress,
potentially
impacting
both
mother
developing
fetus.
Understanding
mechanisms
which
antivirals
examination
pharmacokinetic
changes
pregnancy
that
influence
drug
metabolism
is
essential.
Some
research
indicates
antiretroviral
drugs
induce
mitochondrial
dysfunction
other
studies
suggest
their
use
generally
safe.
Therefore,
concerns
about
long-term
health
effects
persist.
This
review
delves
into
complex
interplay
between
antioxidant
defenses,
antiviral
therapies,
focusing
on
strategies
mitigate
potential
damage.
By
addressing
gaps
our
understanding,
we
highlight
importance
balancing
efficacy
with
risks
stress.
Moreover,
advocate
for
further
develop
safer,
more
effective
therapeutic
approaches
pregnancy.
dynamics
optimizing
outcomes
fetus
infections
Marine Drugs,
Год журнала:
2025,
Номер
23(4), С. 155 - 155
Опубликована: Апрель 3, 2025
The
liver
is
an
active
metabolic
site
that
generates
high
levels
of
reactive
oxygen
species
(ROS).
Oxidative
stress
has
been
implicated
in
the
chronicity
hepatitis
and
B
virus
(HBV)
infection.
This
study
aimed
to
determine
involvement
oxidative
HBV-infected
cells
efficacy
natural
Nrf2
activators.
intracellular
HBV
pregenomic
RNA
copy
number
relative
total
was
measured
by
RT-PCR,
various
protein
expressions
associated
with
were
analyzed
a
Western
blot
analysis.
results
showed
Nrf2,
HO-1,
Akt,
Bcl-xL
proteins
decreased
continuous
infection,
indicating
HBV-positive
exposed
stress.
present
evaluated
anti-HBV
infection
effects
activator
fucoxanthin
(Fx),
marine
carotenoid
from
edible
biological
resources,
including
comparative
pteryxin
(Ptx).
These
activators
suppressed
production
cells,
thus
increasing
expression
HO-1.
In
persistently
infected
transfected
genome,
Keap1
proteins,
which
contribute
suppressing
HBx
involved
replication,
overexpressed.
particular,
activity
these
marked
at
low
concentrations
Fx.
suggests
may
play
significant
role
could
be
valuable
source
for
further
development
through
functional
utilization
food
resources.
Background
and
Aims:
Protein
tyrosine
sulfation
(PTS)
is
a
common
posttranslational
modification
that
regulates
variety
of
physiological
pathological
processes.
However,
the
role
PTS
in
cancer
remains
poorly
understood.
The
goal
this
study
was
to
determine
whether
how
plays
HCC
progression.
Approach
Results:
By
mass
spectrometry
bioinformatics
analysis,
we
identified
SAV1
as
novel
substrate
HCC.
Oxidative
stress
upregulates
transcription
SLC35B2,
Golgi-resident
transporter
sulfate
donor
3ʹ-phosphoadenosine
5ʹ-phosphosulfate,
leading
increased
SAV1.
Sulfation
disrupts
formation
SAV1-MST1
complex,
resulting
decrease
MST1
phosphorylation
subsequent
inactivation
Hippo
signaling.
These
molecular
events
ultimately
foster
growth
cells
both
vivo
vitro.
Moreover,
SLC35B2
target
gene
pathway,
constituting
positive
feedback
loop
facilitates
progression
under
oxidative
stress.
Conclusions:
Our
findings
reveal
regulatory
mechanism
SLC35B2/SAV1
axis
response
stress,
highlighting
its
potential
promising
therapeutic
for
Diffuse
large
B-cell
lymphoma
(DLBCL)
is
an
aggressive
characterized
by
distinct
subtypes
and
heterogeneous
treatment
outcomes.
Oxidative
stress
the
dysregulation
of
related
regulatory
genes
are
prevalent
in
DLBCL,
prompting
investigation
into
nuclear
factor
erythroid
2-related
2
(Nrf2)-kelch-like
ECH-associated
protein
1
(Keap1)
signaling
pathway
associated
genes.
The
present
study
assessed
pathological
specimens
clinical
data
from
43
newly
diagnosed
patients
with
comparing
associations
correlations
between
expression
Nrf2,
Keap1,
microtubule-associated
light
chain
3β
(LC3B)
nitrotyrosine
activated
(ABC)
germinal
center
(GCB)
DLBCL
using
immunohistochemistry
digital
image
analysis
software.
Nuclear
Nrf2
activation
was
observed
33.3%
ABC,
demonstrating
a
higher
prevalence
hepatitis
B
surface
antigen
positivity,
calcium
ions
significant
body
weight
loss
(P<0.05).
Total
GCB
subtype
inversely
correlated
Keap1
ABC
subtype.
Furthermore,
positive
correlation
demonstrated
LC3,
indicating
that
total
inhibited
regulates
LC3
expression.
also
lower
white
blood
cell
counts
more
frequent
chemotherapy
courses
than
These
findings
suggest
could
be
biomarker
for
diagnosis.
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1793 - 1793
Опубликована: Июнь 6, 2024
Background
and
purpose:
Diet
might
be
a
modifiable
factor
in
preventing
cancer
by
modulating
inflammation.
This
study
aims
to
explore
the
association
between
dietary
inflammatory
index
(DII)
score
risk
of
bladder
(BC).
Methods:
A
total
112
BC
patients
292
control
subjects
were
enrolled
case–control
trial.
Additionally,
we
tracked
109
319
controls,
whose
propensity
scores
obtained
from
Nutrition
Examination
Survey
(NHANES)
database
spanning
1999
2020.
The
baseline
intake
data
assessed
using
food
frequency
questionnaire
(FFQ).
DII
calculated
based
on
20
nutrients
participants
categorized
into
four
groups.
potential
diet
was
investigated
multivariate
odds
ratios
(ORs)
95%
confidence
intervals
(CIs).
Results:
High
associated
with
pro-inflammatory
higher
BC,
positively
(quartiles
4
vs.
1,
ORs
4.89,
CIs
2.09–11.25
p
<
0.001).
Specifically,
this
promote
development
inducing
oxidative
stress
affecting
DNA
repair
mechanisms.
result
consistent
NHANES
findings
2.69,
1.25–5.77,
=
0.006)
further
supported
lifestyle
factors
BC.
Conclusions:
Diets
highest
an
increased
By
adjusting
factors,
individuals
effectively
lower
their
DII,
thereby
reducing
developing
results
are
cohort.
Pharmacological Research,
Год журнала:
2024,
Номер
210, С. 107512 - 107512
Опубликована: Дек. 1, 2024
Hepatocellular
carcinoma
(HCC)
comprises
the
majority
of
primary
liver
cancers
and
possesses
a
low
5-year
survival
rate
when
in
advanced
stages.
Anillin
(ANLN),
key
player
cell
growth
cytokinesis,
is
implicated
HCC
development.
Currently,
no
treatment
agents
are
known
to
suppress
ANLN.
Analysis
The
Cancer
Genome
Atlas
data
showed
that
high
ANLN
expression
associated
with
poor
prognosis
patients.
knockdown
was
shown
inhibit
proliferation,
cycle
progression,
PD-L1
cancer
cells.
antipsychotic
drug
penfluridol
identified
Connectivity
Map
analysis.
Penfluridol
downregulated
at
both
mRNA
protein
levels,
leading
G2/M
arrest
reduced
colony
formation
Mechanistically,
inhibited
transcription
factor
MYC
from
binding
an
E-box
motif
promoter.
This
process
mediated
by
penfluridol-induced
upregulation
NRF2,
which
competitively
bound
sequestered
away
interaction
between
NRF2
KEAP1,
increasing
NRF2.
In
syngeneic
mouse
model,
suppressed
tumour
accompanied
increased
decreased
expression.
These
findings
suggest
can
be
applied
as
first
blocker
modulate
MYC/NRF2/KEAP1
axis.
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1518 - 1518
Опубликована: Дек. 12, 2024
Oxidative
stress
plays
a
critical
role
in
various
physiological
and
pathological
processes,
particularly
during
pregnancy,
where
it
can
significantly
affect
maternal
fetal
health.
In
the
context
of
viral
infections,
such
as
those
caused
by
Human
Immunodeficiency
Virus
(HIV)
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
oxidative
may
exacerbate
complications
disrupting
cellular
function
immune
responses.
Antiviral
drugs,
while
essential
managing
these
also
contribute
to
stress,
potentially
impacting
both
mother
developing
fetus.
Understanding
mechanisms
which
antivirals
examination
pharmacokinetic
changes
pregnancy
that
influence
drug
metabolism
is
essential.
Some
research
indicates
antiretroviral
drugs
induce
mitochondrial
dysfunction
other
studies
suggest
their
use
generally
safe.
Therefore,
concerns
about
long-term
health
effects
persist.
This
review
delves
into
complex
interplay
between
antioxidant
defenses,
antiviral
therapies,
focusing
on
strategies
mitigate
potential
damage.
By
addressing
gaps
our
understanding,
we
highlight
importance
balancing
efficacy
with
risks
stress.
Moreover,
advocate
for
further
develop
safer,
more
effective
therapeutic
approaches
pregnancy.
dynamics
optimizing
outcomes
fetus
infections
