Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Ноя. 8, 2024
Breast cancer (BRCA) is the most common malignant tumor among women, characterized by high incidence rates and mortality rates. Oxidative stress immunity, particularly in relation to mitochondria, have emerged as pivotal factors breast carcinogenesis. Nonetheless, limited research has explored specific contribution of mitochondrial oxidative prognosis BRCA.
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2846 - 2846
Опубликована: Фев. 29, 2024
The treatment of patients with advanced cancer poses clinical problems due to the complications that arise as disease progresses. Bone metastases are a common problem may face, and currently, there no effective drugs treat these individuals. Prostate, breast, lung cancers often spread bone, causing significant disabling health conditions. bone is highly active dynamic tissue considered favorable environment for growth cancer. role osteoblasts osteoclasts in process remodeling way which their interactions change during progression metastasis critical understanding pathophysiology this disease. These create self-perpetuating loop stimulates metastatic cells bone. metabolic reprogramming both microenvironment has serious implications development metastasis. Insight into systemic elements regulate process, well cellular changes occur metastases, discovery cure It crucial explore different therapeutic options focus specifically on malignancy order effectively This review will effects disorders factors like hormones cytokines metastases. We also examine various alternatives available today upcoming advances novel treatments.
Язык: Английский
Процитировано
5
Cancer Medicine, Год журнала: 2025, Номер 14(4)
Опубликована: Фев. 1, 2025
ABSTRACT Aim Breast cancer frequently metastasizes to bones. The interaction between breast cells and bone results in osteolytic lesions by disrupting the balance osteoblast‐mediated production osteoclast‐mediated resorption. This study aims investigate effects of cannabinoid receptor type 2 (CB2) agonist, GW405833, on interactions osteoblasts as well its impact cancer‐induced osteoclastogenesis. Materials & Methods MDA‐MB‐231, UMR‐106, RAW 264.7 were used represent cells, osteoblast‐like macrophage‐osteoclast precursor respectively. Cell viability was evaluated MTT assay, cell invasion assessed Transwell assay. Tartrate‐resistant acid phosphatase (TRAP) staining utilized evaluate Results Our demonstrated that GW405833 disrupted MDA‐MB‐231‐induced UMR‐106 death promoted viability. underlying mechanism these determined this study. reduced AKT phosphorylation MDA‐MB‐231 without affecting mTOR protein expression or phosphorylation. Conversely, induced phosphorylated protein. Furthermore, inhibitor reversed GW405833‐induced recovery under MDA‐MB‐231‐derived conditioned media (CM) exposure. These findings underscore critical role AKT/mTOR pathway mediating GW405833's inhibitory cancer‐bone interactions. Additionally, suppressed osteoblast‐enhanced invasion‐related proteins both types, along with reducing osteoclastogenic factors CM suppressing CM‐enhanced osteoclastogenesis cells. Conclusion highlights therapeutic potential agonist for treating metastasis bone‐related complications.
Язык: Английский
Процитировано
0
The FASEB Journal, Год журнала: 2025, Номер 39(7)
Опубликована: Апрель 2, 2025
Lymph node metastasis (LNM) holds substantial implications for the recurrence and survival of cancer patients, but intricate regulatory mechanisms underlying LNM remain poorly understood. MTOGB was dominantly increased in pan-cancer, significantly activated epithelial cells enriched LNM. Subsequently, we identified a specific cell subpopulation, EC4, located at terminal differentiation trajectory Lineage2. By intersecting differentially expressed genes cluster 2, EC4 Lineage2, six crucial genes. Notably, expression Steroid 5α-reductase 3 (SRD5A3) with progression stages. Knockdown SRD5A3 effectively suppressed MTOGB, blocking both animal models. Nilotinib screened as candidate inhibitor confirmed to remarkably decrease metastasis. SOX4 potential transcription factor SRD5A3, modulated by dramatic increase communication SPP1+ macrophages immune microenvironment. The supernatant from macrophage enhanced SOX4/SRD5A3 metastatic ability cells, this effect reversed deletion SPP1. Collectively, our findings illuminate SPP1-SRD5A3 signaling driver suggest that its blockade could be promising option overcoming
Язык: Английский
Процитировано
0
Seminars in Oncology, Год журнала: 2025, Номер 52(2), С. 152340 - 152340
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 21, 2024
Abstract Breast cancer (BC) currently ranks second in the global incidence rate. Hypoxia is a common phenomenon BC. Under hypoxic conditions, cells tumor microenvironment (TME) secrete numerous extracellular vesicles (EVs) to achieve intercellular communication and alter metabolism of primary metastatic tumors that shape TME. In addition, emerging studies have indicated hypoxia can promote resistance treatment. Engineered EVs are expected become carriers for treatment due their high biocompatibility, low immunogenicity, drug delivery efficiency, ease modification. this review, we summarize mechanisms TME distant metastasis BC under conditions. Additionally, highlight potential applications engineered mitigating malignant phenotypes hypoxia.
Язык: Английский
Процитировано
1
Discover Chemistry., Год журнала: 2024, Номер 1(1)
Опубликована: Ноя. 28, 2024
Triple-negative breast cancer (TNBC), the most aggressive form of cancer, presents a significant mortality risk owing to its elevated potential for metastasis. The overexpression Murine Double Minute 2 homolog (MDM2) protein, key suppressor tumour p53, in TNBC amplifies growth, advancement, and invasiveness. Thus, inhibiting MDM2 protein emerges as compelling strategy enhance efficacy treatment. We aimed identify novel inhibitors from natural marine compounds, known their distinctive chemical structures heightened anticancer activities, utilizing molecular docking, ADME/T analysis, dynamics (MD) simulations, MM-PBSA calculations, silico PASS predictions. A compound library was constructed initial screening purpose docking analysis revealed that two namely 10,11-dihydrosodwanone B sodwanone T, exhibited significantly higher binding affinity (− 9.6 kcal/mol − 9.1 kcal/mol, respectively) compared established inhibitor nutlin-3a 8.4 kcal/mol). investigations were conducted ensure drug-likeness properties safety these compounds. Additionally, tool predicted both compounds possess activities. Molecular simulations (100 ns) calculations indicated T formed relatively more stable complex had binding-free energy with MDM2, respectively. In conclusion, this research suggests promising candidate further testing development an therapeutic applications against TNBC. Nevertheless, substantial experimental clinical are necessary applicability settings.
Язык: Английский
Процитировано
1
Neuroglia, Год журнала: 2024, Номер 5(2), С. 155 - 164
Опубликована: Июнь 1, 2024
The current lack of a comprehensive understanding brain metastasis mechanisms presents significant gap in cancer research. This review outlines the role that Schwann cells (SCs) have this process. SCs are already known for their myelination and nerve repair within peripheral nervous system (PNS), but there is less information on function facilitating transport activation neoplastic to aid invasion blood–brain barrier brain. Detailed insights into SCs’ interactions with various cancers, including lung, breast, melanoma, colon, kidney, pancreatic reveal how these coerced repair-like phenotypes accelerate spread modulate immune responses. By outlining involvement perineural BBB modification, highlights functions metastasis.
Язык: Английский
Процитировано
0
BIO Web of Conferences, Год журнала: 2024, Номер 124, С. 02015 - 02015
Опубликована: Янв. 1, 2024
Breast cancer ranks as a leading cause of cancer-related deaths in women globally. Current treatments often fall short eradicating it completely, posing challenges managing its incidence and mortality rates. The nervous system significantly influences breast initiation, progression, metastasis. review highlights how the hypothalamic-pituitary-adrenal axis central peripheral nerves, such parasympathetic sympathetic can either promote or inhibit development through neurotransmitter release. Understanding these mechanisms offers new therapeutic targets, potentially improving diagnosis treatment strategies.
Язык: Английский
Процитировано
0
Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(5), С. 100949 - 100949
Опубликована: Авг. 23, 2024
Tumor metastasis is responsible for 90% of cancer-associated deaths, and its early detection may decrease the likelihood mortality. Studies have demonstrated that results from interaction between "seeds" (tumor cells) "soil" (pre-metastatic niche, PMN). As first most abundant immune cells to be recruited PMN, neutrophils play a key role in ultimate formation metastatic foci through mechanisms such as supporting tumor cell growth, promoting angiogenesis, shaping an immune-suppressive microenvironment. In this study, two distinct types sialic acid (SA)-modified liposomes were prepared target regulate pro-metastatic l-selectin receptor. One these liposomes, named ICG@SAL, was used encapsulate indocyanine green (ICG) specifically designed cancer metastasis. The other liposome, referred ABE/Cur@SAL, co-loaded abemaciclib (ABE) curcumin (Cur), with intention suppressing progression tumor. Fluorescence imaging mouse spontaneous model indicated ICG@SAL faster targeting stronger accumulation organs than unmodified ICG (ICG@CL). This suggested could detect at stage. therapy experimental lung ABE/Cur@SAL inhibit regulatory T (Treg) proliferation, enhance effector activity reduce tumorigenic factor release, implying Overall, our work provided sensitive convenient approach diagnosis treatment employed metastasis, while development when identified.
Язык: Английский
Процитировано
0
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Ноя. 8, 2024
Breast cancer (BRCA) is the most common malignant tumor among women, characterized by high incidence rates and mortality rates. Oxidative stress immunity, particularly in relation to mitochondria, have emerged as pivotal factors breast carcinogenesis. Nonetheless, limited research has explored specific contribution of mitochondrial oxidative prognosis BRCA.
Язык: Английский
Процитировано
0