Journal of drug targeting,
Год журнала:
2024,
Номер
unknown, С. 1 - 26
Опубликована: Окт. 15, 2024
Breast
cancer
(BC)
is
a
major
cause
of
cancer-related
mortality
across
the
globe
and
especially
highly
prevalent
in
females.
Based
on
poor
outcomes
several
limitations
present
management
approaches
BC,
there
an
urgent
need
to
focus
explore
alternate
target
possible
drug
candidates
against
BC.
The
accumulation
misfolded
proteins
subsequent
activation
unfolded
protein
response
(UPR)
alters
homeostasis
endoplasmic
reticulum
(ER)
lumen
that
ultimately
causes
oxidative
stress
ER.
UPR
activates
stress-detecting
such
as
IRE1α,
PERK,
ATF6,
these
sometimes
may
lead
pro-apoptotic
signaling
pathways
cancerous
cells.
ER
stress-dependent
antitumor
activity
could
be
achieved
either
through
suppressing
adaptive
make
cells
susceptible
or
by
causing
chronic
triggering
pathways.
Several
herbal
drugs
trigger
ER-dependent
apoptosis
BC
Therefore,
this
review
discussed
role
fifty-two
their
active
constituents,
focusing
disrupting
balance
within
Further,
challenges
opportunities
have
also
been
BC.Breast
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8621 - 8621
Опубликована: Авг. 7, 2024
Inflammation
is
activated
by
diverse
triggers
that
induce
the
expression
of
cytokines
and
adhesion
molecules,
which
permit
a
succession
molecules
cells
to
deliver
stimuli
functions
help
immune
system
clear
primary
cause
tissue
damage,
whether
this
an
infection,
tumor,
or
trauma.
During
inflammation,
short-term
changes
in
secretion
strong
mediators
inflammation
occur,
while
long-term
occur
specific
groups
cells.
Long-term
include
cellular
transdifferentiation
for
some
types
need
regenerate
damaged
tissue,
as
well
death
can
be
detrimental
integrity
if
they
remain
active
beyond
boundaries
essential
function.
The
transcriptional
regulator
NFκB
enables
fundamental
gene
during
development.
recurrence
malignant
disease,
cell
stress-induced
alterations
enable
growth
cancer
clones
are
substantially
resistant
therapeutic
intervention
system.
A
number
those
due
significant
defects
feedback
signal
cascades
control
activity
NFκB.
Specifically,
stress
contributes
it
overrides
modules
otherwise
protect
host
tissue.
involved
both
suppression
promotion
cancer,
key
distinctive
feature
determines
its
net
effect
remains
unclear.
This
paper
aims
provide
answer
at
least
one
aspect
question,
namely
mechanism
divergent
response
critical
inflammatory
general.
Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(8)
Опубликована: Окт. 25, 2024
ABSTRACT
The
endothelial
semipermeable
monolayers
ensure
tissue
homeostasis,
are
subjected
to
a
plethora
of
stimuli,
and
their
function
depends
on
cytoskeletal
integrity
remodeling.
permeability
those
membranes
can
fluctuate
maintain
organ
homeostasis.
In
cases
severe
injury,
inflammation
or
disease,
barrier
hyperpermeability
cause
irreparable
damage
endothelium‐dependent
issues,
eventually
death.
Elucidation
the
signaling
regulating
structure
promotes
development
targeted
pharmacotherapies
towards
disorders
related
impaired
endothelium
(e.g.,
acute
respiratory
distress
syndrome,
sepsis).
Recent
reports
investigate
role
unfolded
protein
response
in
function.
Herein
we
review
components,
function;
interrelations
health
disorder.
Moreover,
emphasize
modulators,
since
they
ameliorate
illness
leak.
Genes,
Год журнала:
2024,
Номер
15(6), С. 658 - 658
Опубликована: Май 22, 2024
The
increase
in
hypoxia
events,
a
result
of
climate
change
coastal
and
fjord
ecosystems,
impacts
the
health
survival
mussels.
These
organisms
deploy
physiological
molecular
responses
as
an
adaptive
mechanism
to
maintain
cellular
homeostasis
under
environmental
stress.
However,
specific
effects
on
mussels
socioeconomic
interest,
such
Mytilus
chilensis,
are
unknown.
Using
RNA-seq,
we
investigated
transcriptomic
profiles
gills,
digestive
gland,
adductor
muscle
M.
chilensis
(10
days
at
2
mg
L−1)
reoxygenation
6
L−1).
There
were
15,056
differentially
expressed
transcripts
identified
11,864
9862
muscle.
response
varied
among
tissues,
showing
chromosomal
changes
Chr1,
Chr9,
Chr10
during
hypoxia.
Hypoxia
regulated
signaling
genes
Toll-like,
mTOR,
citrate
cycle,
apoptosis
pathways
indicating
metabolic
immunological
alterations.
suggest
that
induced
shift
mussels,
reducing
reliance
aerobic
respiration
increasing
anaerobic
metabolism.
Furthermore,
appeared
suppress
immune
response,
potentially
disease
susceptibility,
with
negative
implications
for
mussel
culture
industry
natural
bed
populations.
This
study
provides
pivotal
insights
into
adaptations
offering
candidate
traits.
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Окт. 31, 2024
The
diagnosis
of
lymphomas
is
challenging
due
to
their
diverse
histological
presentations
and
clinical
manifestations.
There
a
need
for
inexpensive
tools
that
require
minimal
expertise
are
accessible
routine
laboratories.
Contrastingly,
current
conventional
diagnostic
methods
often
found
only
in
specialized
environments.
Attenuated
total
reflection-Fourier
transform
infrared
(ATR-FTIR)
spectroscopy
offers
nondestructive
user-friendly
approach
the
analysis
wide
range
samples.
In
this
paper,
we
determined
whether
technique
coupled
with
machine
learning
can
detect
differentiate
lymphoma
within
lymphoid
tissue
Tissue
sections
from
295
individuals
diagnosed
389
without
disease
were
analyzed
using
ATR-FTIR
spectroscopy.
resulting
spectral
dataset
was
split
70:30
train-test
split.
Partial
least
Squares
Discriminant
Analysis
(PLS-DA)
models
trained
distinguish
non-malignant
samples
between
subtypes.
On
training
set
(n
=
478),
significant
differences
mainly
identified
1800-900
cm
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 15, 2024
AbstractBackground:
Ovarian
carcinoma
is
one
of
the
most
common
gynecological
cancers
with
high
mortality
rates.
Succinate
dehydrogenase
(SDH
or
Complex
II)
which
important
enzymes
in
tricarboxylic
acid
(TCA)
cycle
plays
an
role
carcinomas.
subunit
B
(SDHB)
gene,
encodes
four
subunits
SDH,
has
been
found
played
as
a
tumor
suppressor
ovarian
cancer.
However,
SDHB
cancer
chemotherapy
still
unclear.
Methods:
Using
specific
siRNA
and
overexpression
plasmid,
expression
was
silenced
conversely
induced
cell
lines
SKOV3
A2780,
respectively.
The
possible
investigated
vitro
using
CCK8
Colony
formation
assays.
Real-time
PCR
used
to
exam
SDH
tissues
normal
tissues.
Immunohistochemistry
human
cisplatin-resistant
corresponding
cisplatin-sensitive
To
explore
mechanism,
epithelial
mesenchymal
transition
(EMT)
DNA
damage
repair
related
proteins
such
E-cadherin,
Vimentin,
γ-H2AX
ERCC1
were
examined
by
western
blot
A2780
cells.
EMT
transcription
factors
Slug,
Snail
Twist
mRNA
levels
quantitative
real-time
reverse
transcriptase
PCR.
Results:
expressed
lower
than
tissues,
being
Moreover,
metastatic
that
primary
In
cells,
E-cadherin
decreased,
Vimentin
increased.
EMT-
Slug
significantly
increased
(P<0.05),
while
showed
no
significant
increase
(P>0.05)
SDHB-silenced
contrast,
reduced
silencing
drug
resistance
opposite
results
level
ERCC1,
contributes
platinum
promoting
repair,
increased,
γ-H2AX,
apoptosis
Conclusions:
cells
significantly,
its
mechanism
might
be
inhibiting
further
reducing
their
ability
thereby
resistance,
provides
preliminary
experimental
theoretical
basis
for
treatment
