Critical Reviews in Eukaryotic Gene Expression,
Год журнала:
2024,
Номер
35(2), С. 87 - 95
Опубликована: Дек. 30, 2024
RNA
methylation
is
involved
in
the
pathogenesis
of
ankylosing
spondylitis
(AS).
This
study
aimed
to
investigate
potentials
METTL17
AS.
mRNA
expression
was
detected
using
RT-qPCR.
MeRIP
assay.
Protein
western
blot.
Cell
proliferation
EdU
Macrophage
functions
flow
cytometry.
upregulated
after
exposure
LPS.
However,
knockdown
promoted
inflammatory
response.
Moreover,
M1
macrophage
polarization.
Mechanically,
regulate
methylation.
STAT1,
inhibiting
and
protein
stability
STAT1.
In
summary,
inhibits
response
polarization
via
mediating
Therefore,
targeting
METTL17/STAT1
may
be
a
promising
strategy
for
In
parallel
with
population
aging,
the
prevalence
of
neurological
and
neurodegenerative
diseases
has
been
dramatically
increasing
over
past
few
decades.
Neurodegenerative
reduce
quality
life
patients
impose
a
high
cost
on
health
system.
These
slowly
progressive
can
cause
functional,
perceptual,
behavioral
deficits
in
patients.
Therefore,
impairments
have
always
an
interesting
subject
for
scientists
clinicians.
One
these
is
spinal
cord
injury
(SCI).
SCI
lead
to
irreversible
damage
classified
into
two
main
subtypes:
traumatic
non-traumatic,
each
very
different
pathophysiological
features.
Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(9)
Опубликована: Сен. 19, 2024
Spinal
cord
injury
(SCI)
is
a
severe
central
nervous
system
disorder
with
no
currently
available
effective
treatment.
Microglia
are
immune
cells
in
the
that
play
crucial
roles
SCI
occurrence,
development,
and
recovery
stages.
They
exhibit
dynamic
polarization
over
time
can
switch
between
classical
activation
(M1)
alternative
(M2)
phenotypes
to
respond
environmental
stimuli.
The
M1
phenotype
involved
initiating
sustaining
inflammatory
responses,
while
M2
exerts
anti-inflammatory
effects
promotes
tissue
repair
damaged
areas.
Inhibiting
promoting
have
become
hotspots
regulating
neuroinflammation
treating
SCI.
This
article
provides
comprehensive
review
centered
on
modulating
microglial
for
Critical Reviews in Eukaryotic Gene Expression,
Год журнала:
2024,
Номер
35(2), С. 87 - 95
Опубликована: Дек. 30, 2024
RNA
methylation
is
involved
in
the
pathogenesis
of
ankylosing
spondylitis
(AS).
This
study
aimed
to
investigate
potentials
METTL17
AS.
mRNA
expression
was
detected
using
RT-qPCR.
MeRIP
assay.
Protein
western
blot.
Cell
proliferation
EdU
Macrophage
functions
flow
cytometry.
upregulated
after
exposure
LPS.
However,
knockdown
promoted
inflammatory
response.
Moreover,
M1
macrophage
polarization.
Mechanically,
regulate
methylation.
STAT1,
inhibiting
and
protein
stability
STAT1.
In
summary,
inhibits
response
polarization
via
mediating
Therefore,
targeting
METTL17/STAT1
may
be
a
promising
strategy
for
