Targeting cGAS-STING pathway for reprogramming tumor-associated macrophages to enhance anti-tumor immunotherapy
Biomarker Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Март 12, 2025
Abstract
The
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
genes
(STING)
signaling
pathway
plays
a
crucial
role
in
activating
innate
and
specific
immunity
anti-tumor
immunotherapy.
As
the
major
infiltrating
cells
tumor
microenvironment
(TME),
tumor-associated
macrophages
(TAMs)
could
be
polarized
into
either
M1
or
pro-tumor
M2
types
based
on
various
stimuli.
Accordingly,
targeted
reprogramming
TAMs
to
restore
immune
balance
shows
promise
as
an
effective
strategy.
In
this
review,
we
aim
target
cGAS-STING
for
enhance
We
investigated
double-edged
sword
effects
of
regulating
TME.
regulative
roles
its
impact
TME
were
further
revealed.
More
importantly,
several
strategies
targeting
designed
enhancing
Taken
together,
might
promising
strategy
Язык: Английский
Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications
Medical Oncology,
Год журнала:
2024,
Номер
41(11)
Опубликована: Окт. 18, 2024
Язык: Английский
STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Abstract
As
cancer
continues
to
rank
among
the
leading
causes
of
death,
demand
for
novel
treatments
has
never
been
higher.
Immunotherapy
shows
promise,
yet
many
solid
tumors
such
as
pancreatic
or
glioblastoma
remain
resistant.
In
these,
“cold”
tumor
microenvironment
with
low
immune
cell
infiltration
and
inactive
anti‐tumoral
cells
leads
increased
resistance
these
drugs.
This
driven
development
several
drug
candidates,
including
stimulators
interferon
genes
(STING)
agonists
reprogram
system
fight
off
tumors.
Preclinical
studies
demonstrated
that
STING
can
trigger
immunity
cycle
increase
type
I
secretion
T
activation,
which
subsequently
induces
regression.
Despite
promising
preclinical
data,
biological
physical
challenges
persist
in
translating
success
into
clinical
trials.
Nonetheless,
combination
strategies
are
emerging,
investigating
other
immunotherapies,
presenting
encouraging
results.
review
will
examine
potential
assess
benefits
employing
them
immunotherapy.
Язык: Английский
Decoding STING’s roles in cancer: immunity, pain, dormancy, and autophagy
Molecular and Cellular Biochemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Язык: Английский
Berbamine As Potential STING Inhibitor For KRAS-Mutant Non-Small Cell Lung Cancer
Pharmacological Research,
Год журнала:
2025,
Номер
216, С. 107777 - 107777
Опубликована: Май 16, 2025
Lung
adenocarcinoma
(LUAD)
is
a
leading
cause
of
cancer-related
mortality.
Poor
prognostic
results
in
LUAD
are
frequently
associated
with
KRAS
mutations
and
drug
resistance.
can
induce
STING
activation
by
triggering
DNA
damage
response
(DDR)
activation.
This
persistently
activated
signaling
gives
rise
to
an
immunosuppressive
microenvironment,
thereby
complicating
treatment
efforts.
In
this
study,
we
identified
that
the
low-toxicity
pro-apoptotic
Berbamine
(BBM)
as
potential
therapeutic
agent
for
cells
mutations.
BBM
exhibits
anti-tumor
effects
cell
cycle
arrest,
enhancing
senescence,
activating
apoptosis.
also
targets
STING,
downregulation
p-STING
(Ser366)
CCL2.
turn
reduced
infiltration
M-MDSCs
into
tumor
microenvironment.
These
combined
mechanisms
not
only
suppress
STING-dependent
growth
but
remodel
immunity.
Collectively,
our
findings
position
promising
mutations,
offering
strategy
target
STING-associated
pathways,
overcome
immune
suppression,
ultimately
improve
patient
outcomes.
Язык: Английский
<i>STIL</i> enhances the development of lung adenocarcinoma by regulating the glycolysis pathway
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics,
Год журнала:
2024,
Номер
33(1), С. 123 - 132
Опубликована: Май 29, 2024
Background:
To
investigate
STIL
centriolar
assembly
protein
(STIL)'s
role
and
prognostic
significance
in
lung
adenocarcinoma
(LUAD)
progression,
we
examined
E2
promoter
binding
factor
1
(E2F1)
expressions
their
impacts
on
LUAD
prognosis
using
Gene
Expression
Profiling
Interactive
Analysis
(GEPIA).Methods:
Functional
assays
including
CCK-8,
wound-healing,
5-ethynyl-2-deoxyuridine
(EdU),
Transwell
assays,
flow
cytometry,
elucidated
E2F1's
effects
cell
viability,
proliferation,
apoptosis,
migration.GSEA
identified
potential
pathways,
while
metabolic
assessed
glucose
metabolism.Results:
Our
findings
reveal
that
E2F1
are
overexpressed
LUAD,
correlating
with
adverse
outcomes.It
enhances
migration,
invasion,
suppresses
activating
downstream
of
E2F1.Silencing
reversed
the
promotion
effect
overexpression
viability
invasiveness.Importantly,
modulates
glycolysis,
influencing
consumption,
lactate
production,
energy
balance
cells.Conclusion:
model,
incorporating
STIL,
age,
disease
stage,
robustly
predicts
patient
prognosis,
underscoring
STIL's
pivotal
pathogenesis
through
reprogramming.This
comprehensive
approach
not
only
confirms
value
but
also
highlights
its
as
a
therapeutic
target
LUAD.
Язык: Английский