Novel Factors Regulating Proliferation, Migration, and Differentiation of Fibroblasts, Keratinocytes, and Vascular Smooth Muscle Cells during Wound Healing
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 1939 - 1939
Опубликована: Авг. 23, 2024
Chronic
diabetic
foot
ulcers
(DFUs)
are
a
significant
complication
of
diabetes
mellitus,
often
leading
to
amputation,
increased
morbidity,
and
substantial
financial
burden.
Even
with
the
advancements
in
treatment
DFU,
risk
amputation
still
exists,
this
occurs
due
presence
gangrene
osteomyelitis.
Nonhealing
chronic
DFU
is
decreased
angiogenesis,
granulation
tissue
formation,
extracellular
matrix
remodeling
persistent
inflammation.
During
wound
healing,
proliferation
migration
fibroblasts,
smooth
muscle
cells,
keratinocytes
play
critical
role
(ECM)
remodeling,
epithelialization.
The
molecular
factors
regulating
migration,
proliferation,
differentiation
these
cells
scarcely
discussed
literature.
literature
review
identifies
key
influencing
keratinocytes,
vascular
(VSMCs),
which
healing.
This
followed
by
discussion
on
various
novel
but
not
context
healing;
however,
they
may
role.
Using
network
analysis,
we
examined
interactions
between
factors,
findings
suggest
that
identified
promoting
during
healing
or
However,
warrant
further
investigation
establish
their
alone
synergistically.
Язык: Английский
Skin Structure, Physiology, and Pathology in Topical and Transdermal Drug Delivery
Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1403 - 1403
Опубликована: Окт. 31, 2024
Several
industries
are
increasingly
focused
on
enhancing
the
delivery
of
active
ingredients
through
skin
to
optimize
therapeutic
outcomes.
By
facilitating
penetration
barrier,
these
enhancers
can
significantly
improve
efficacy
various
formulations,
ranging
from
skincare
products
agents
targeting
systemic
circulation.
As
understanding
physiology
and
mechanisms
drug
absorption
deepen,
adopting
permeation
more
widely,
ultimately
leading
better
patient
outcomes
expanded
treatment
options.
However,
structure
physiological
function
vary
according
different
factors,
such
as
area
body
between
individuals.
These
variations,
along
with
external
environmental
exposures,
aging
pathological
conditions,
introduce
complexities
that
must
be
carefully
considered
when
designing
effective
systems.
Considering
intricacies
physiology,
tailoring
systems
account
for
regional
differences,
individual
variability,
changes
induced
by
factors
or
disease
is
critical
optimizing
This
review
discusses
features
structure,
pathologies,
well
application
in
contexts.
Furthermore,
it
addresses
use
animal
models
transdermal
dermatological
studies,
latest
developments
this
field.
Язык: Английский
Vicenin-2 reduces inflammation and apoptosis to relieve skin photoaging via suppressing GSK3β
Journal of Photochemistry and Photobiology B Biology,
Год журнала:
2025,
Номер
264, С. 113117 - 113117
Опубликована: Фев. 6, 2025
Язык: Английский
Lithocholic Acid Oleate Preparative Synthesis and Its Formulation with Lithocholic Acid as a Preventive Antiviral: In Vitro and In Vivo Assays Against HSV-1 as a Viral Infection Model
Viruses,
Год журнала:
2025,
Номер
17(3), С. 416 - 416
Опубликована: Март 14, 2025
The
discovery
and
design
of
antiviral
agents
have
gained
unprecedented
significance
due
to
the
emergence
global
health
threats.
use
synthetic
chemistry
has
enabled
modification
existing
molecules
creation
entirely
novel
compounds.
In
our
laboratory,
we
enzymatically
synthesized
a
bioconjugate,
lithocholic
acid
oleate
(LO),
derived
from
(LCA),
bile
that
been
proven
by
researchers
exhibit
activity
in
vitro.
study
presented
herein
describes
preparative
synthesis,
formulation,
evaluation
LO
both
vitro
vivo
for
its
against
human
herpes
simplex
virus
1
(HSV-1)
as
model
viral
infection.
Evaluation
cytotoxicity
using
A549
cells
indicated
combination
(400
μM)
LCA
(30
exhibited
favorable
safety
profile
while
effectively
inhibiting
HSV-1
infection
comparable
acyclovir
treatment.
Furthermore,
assay,
animals
treated
with
an
oily
formulation
containing
7%
LO;
0.50%
LCA;
3%
oleic
(OA),
48
h
prior
exposure,
showed
results
even
superior
5%
commercial
terms
scar
formation
wound
recovery.
These
promising
enable
development
new
preventive
products
probably
other
viruses.
Язык: Английский
The Role of IL-23 in the Development of Inflammatory Diseases
Biology,
Год журнала:
2025,
Номер
14(4), С. 347 - 347
Опубликована: Март 27, 2025
Interleukin-23
is
crucial
in
the
initiation
and
progression
of
certain
inflammatory
disorders.
As
a
key
cytokine,
IL-23
involved
differentiation
activation
Th17
cells,
which
play
role
broad
spectrum
diseases.
This
review
examines
molecular
mechanisms
through
contributes
to
pathogenesis
conditions
including
psoriasis,
rheumatoid
arthritis,
bowel
disease,
multiple
sclerosis.
By
elucidating
significant
inflammation,
this
underscores
its
importance
as
therapeutic
target
for
managing
conditions,
with
particular
emphasis
on
current
emerging
biologic
treatments.
Язык: Английский
Pathophysiologie der Fibrose – entzündlich vs. nichtentzündlich
Deleted Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Fibrosis
is
characterized
by
an
excessive
accumulation
of
extracellular
matrix
components
produced
connective
tissue
cells.
It
a
pathophysiological
feature
many
chronic
inflammatory
diseases.
Nearly
every
the
body
can
be
affected
fibrosis.
Its
progression
lead
to
dysfunction
and
organs
potentially
death.
Early
fibrotic
mechanisms
include
activation
immune
responses
leading
cells
misdirected
wound
healing
responses,
finally
scarring
Different
pathways
factors
contribute
pathophysiology
fibrosis
are
summarized
in
this
review.
Язык: Английский
Study of natto extract for the amelioration of dinitrochlorobenzene-induced atopic dermatitis by integrating untargeted metabolomics, network pharmacology, and molecular simulation
Jin Wang,
Z.H.A.N.G. Li-Wen,
K.U.A.N.G. Zhe-Lin
и другие.
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106510 - 106510
Опубликована: Апрель 1, 2025
Язык: Английский
Emerging Technological Advancement for Chronic Wound Treatment and Their Role in Accelerating Wound Healing
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(11), С. 7101 - 7132
Опубликована: Окт. 28, 2024
Chronic
wounds
are
a
major
healthcare
burden
and
may
severely
affect
the
social,
mental,
economic
status
of
patients.
Any
impairment
in
wound
healing
stages
due
to
underlying
factors
leads
prolonged
time
subsequently
chronic
wounds.
Traditional
approaches
for
treatment
include
dressing
free
local
therapy,
tissue
engineering
based
scaffold
therapies.
However,
traditional
therapies
need
improvisation
have
been
advanced
through
breakthrough
technologies.
The
present
review
spans
further
gives
an
extensive
account
advancements
Cutting
edge
technologies,
such
as
3D
printing,
which
includes
inkjet
fused
deposition
modeling,
digital
light
processing,
extrusion-based
microneedle
array-based
therapies,
gene
microRNAs
(miRNAs)
smart
dressings
real
monitoring
conditions
assessment
pH,
temperature,
oxygen,
moisture,
metabolites,
their
use
planning
better
strategies
discussed
detail.
future
direction
treatments
that
will
aid
lowering
caused
Язык: Английский