Interleukin-37 modulates microglial phenotype and inhibits inflammatory response via the MyD88/NF-κB pathway in Lipopolysaccharide-induced neuroinflammation DOI Creative Commons
Jiangwen Zhang, Muhammad Abid Hayat,

Yu Si

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

Abstract Objective Interleukin-37 (IL-37), an anti-inflammatory cytokine within the interleukin-1 (IL-1) family, exhibits immunomodulatory properties. Here we evaluate effects of IL-37 on microglia in neuroinflammation and its potential mechanisms. Methods C57BL/6 mice were injected intraperitoneally with 1 μg recombinant human protein (rhIL-37), 24 h later lipopolysaccharide (LPS) (5 mg/kg) to induce neuroinflammation. After 2-hour pretreatment BV2 cells rhIL-37 (100 ng/mL), vitro model was established by treating LPS ng/mL). Mice assessed for behavioral tests, neuronal damage evaluated Nissl staining hematoxylin eosin staining. The expression Iba1, CD86, CD206, NF-κB detected immunofluorescence staining, inflammatory mediators pathway proteins ELISA, qRT-PCR, Western blot. Results significantly ameliorated LPS-induced deficits protected from injury. In experiments suggested that modulates polarization M1 M2 phenotype, along reducing pro-inflammatory production. Moreover, attenuated production MyD88. Conclusions regulates against neuroinflammatory responses blocking MyD88/NF-κB shows first time how influences phenotype microglia, suggesting a therapeutic target

Язык: Английский

The Role of Brain-Derived Neurotrophic Factor as an Essential Mediator in Neuronal Functions and the Therapeutic Potential of Its Mimetics for Neuroprotection in Neurologic and Psychiatric Disorders DOI Creative Commons

Tadahiro Numakawa,

Ryutaro Kajihara

Molecules, Год журнала: 2025, Номер 30(4), С. 848 - 848

Опубликована: Фев. 12, 2025

Among neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4/5), BDNF has been extensively studied for its physiological role in cell survival synaptic regulation the central nervous system's (CNS's) neurons. binds to TrkB (a tyrosine kinase) with high affinity, resulting downstream intracellular signaling cascades play crucial roles determining fate, neuronal differentiation maturation of CNS It well demonstrated that downregulation/dysregulation BDNF/TrkB system is implicated pathogenesis neurologic psychiatric disorders, such as Alzheimer's disease (AD) depression. Interestingly, effects mimetic compounds flavonoids, small molecules which can activate TrkB-mediated signaling, have investigated potential therapeutic strategies brain diseases, given p75NTR, a common neurotrophin receptor, also contributes death under variety pathological conditions neurodegeneration. Since downregulation associated pathophysiology neurodegenerative diseases understanding how alterations contribute progression could provide valuable insight prevention these diseases. The present review shows recent advances molecular mechanisms underlying plasticity, providing critical insights into impact mimetics

Язык: Английский

Процитировано

6
Exogenous L-fucose attenuates depression induced by chronic unpredictable stress: implicating core fucosylation has an antidepressant potential DOI Creative Commons
Dan Wang, Tomohiko Fukuda,

Tiangui Wu

и другие.

Journal of Biological Chemistry, Год журнала: 2025, Номер unknown, С. 108230 - 108230

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Spontaneous Reaction of Oleacein and Oleocanthal with Primary Amines: A Biochemical Perspective DOI Creative Commons
Daniel Di Risola,

Davide Laurenti,

F. Ferraro

и другие.

Molecules, Год журнала: 2025, Номер 30(7), С. 1645 - 1645

Опубликована: Апрель 7, 2025

Oleacein (Olea) and Oleocanthal (Oleo) are two phenolic compounds found in olive oil. Cell animal studies have shown these can modulate inflammation, cancer, neurodegenerative diseases. Unfortunately, the study of pharmacokinetics appears difficult due to their high reactivity with primary amines. Indeed, presence amines culture media biological fluids raises question as whether observed effects attributable parent or amine derivatives. In present work, we investigated adduct formation between Olea Oleo tris(hydroxymethyl)aminomethane (Tris), a well-known used primarily buffer system, showing that reaction kinetics were extremely rapid. addition, assessed newly formed Tris adducts, i.e., Olea-Tris Oleo-Tris, retained antioxidant capacity by means ABTS DPPH radical scavenging assays, activity was partially maintained. Finally, evaluated anti-inflammatory adducts on murine BV-2 microglial cells stimulated lipopolysaccharide (LPS) kept an amine-free medium, how response varied compound degraded. Taken together, data demonstrate reported literature mainly amino-derivatives rather than polyphenols derived from breakdown (tyrosol hydroxytyrosol).

Язык: Английский

Процитировано

0
Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora DOI Creative Commons
Ana Leonor Pardo Campos Godoy,

Fernanda Fortes Frota,

Larissa Parreira Araújo

и другие.

Biomedicines, Год журнала: 2025, Номер 13(5), С. 1129 - 1129

Опубликована: Май 7, 2025

Background/Objectives: Major depressive disorder (MDD) is a major global health concern that intimately linked to neuroinflammation, oxidative stress, mitochondrial dysfunction, and complicated metabolic abnormalities. Traditional antidepressants frequently fall short, highlighting the urgent need for new, safer, more acceptable therapeutic techniques. Phytochemicals, i.e., natural derived from plants, are emerging as powerful plant-based therapies capable of targeting many pathogenic pathways at same time. Summary: This narrative review synthesizes evidence preclinical clinical studies on efficacy phytochemicals such curcumin, polyphenols, flavonoids, alkaloids in lowering depressed symptoms. Consistent data show these substances have neuroprotective, anti-inflammatory, antioxidant properties, altering neuroimmune interactions, reducing damage, improving resilience. Particularly, polyphenols flavonoids great potential because their capacity penetrate blood–brain barrier, inhibit cytokine activity, encourage neuroplasticity mediated by brain-derived neurotrophic factor (BDNF). Despite promising results, heterogeneity study designs, phytochemical formulations, patient demographics highlights importance thorough, standardized studies. Conclusions: identifies compelling adjuvant or independent depression treatment, providing multimodal mechanisms enhanced tolerability. Additional research into improved dosage, pharmacokinetics, long-term safety, integrative therapy approaches essential. Using phytotherapeutics could considerably improve holistic customized care, encouraging new routes neuroscience psychiatry.

Язык: Английский

Процитировано

0
Interleukin-37 modulates microglial phenotype and inhibits inflammatory response via the MyD88/NF-κB pathway in lipopolysaccharide-induced neuroinflammation DOI
Jingwen Zhang, Muhammad Abid Hayat,

Yu Si

и другие.

Inflammation Research, Год журнала: 2025, Номер 74(1)

Опубликована: Май 29, 2025

Язык: Английский

Процитировано

0
Bifidobacterium lactis-Derived Vesicles Attenuate Hippocampal Neuroinflammation by Targeting IL-33 to Regulate FoxO6/P53 Signaling DOI Open Access
Xiaoyu Du, Ming Zhang, Ran Wang

и другие.

Nutrients, Год журнала: 2024, Номер 16(21), С. 3586 - 3586

Опубликована: Окт. 22, 2024

Hippocampal Neuroinflammation (HNF) is a critical driver of cognitive impairment. The lipopolysaccharide (LPS) accumulate amyloid beta (Aβ) and lead to HNF.

Язык: Английский

Процитировано

2
Interleukin-37 modulates microglial phenotype and inhibits inflammatory response via the MyD88/NF-κB pathway in Lipopolysaccharide-induced neuroinflammation DOI Creative Commons
Jiangwen Zhang, Muhammad Abid Hayat,

Yu Si

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

Abstract Objective Interleukin-37 (IL-37), an anti-inflammatory cytokine within the interleukin-1 (IL-1) family, exhibits immunomodulatory properties. Here we evaluate effects of IL-37 on microglia in neuroinflammation and its potential mechanisms. Methods C57BL/6 mice were injected intraperitoneally with 1 μg recombinant human protein (rhIL-37), 24 h later lipopolysaccharide (LPS) (5 mg/kg) to induce neuroinflammation. After 2-hour pretreatment BV2 cells rhIL-37 (100 ng/mL), vitro model was established by treating LPS ng/mL). Mice assessed for behavioral tests, neuronal damage evaluated Nissl staining hematoxylin eosin staining. The expression Iba1, CD86, CD206, NF-κB detected immunofluorescence staining, inflammatory mediators pathway proteins ELISA, qRT-PCR, Western blot. Results significantly ameliorated LPS-induced deficits protected from injury. In experiments suggested that modulates polarization M1 M2 phenotype, along reducing pro-inflammatory production. Moreover, attenuated production MyD88. Conclusions regulates against neuroinflammatory responses blocking MyD88/NF-κB shows first time how influences phenotype microglia, suggesting a therapeutic target

Язык: Английский

Процитировано

0