Meteorin‐like protein plasma levels are associated with worse outcomes in de novo heart failure
European Journal of Clinical Investigation,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Abstract
Background
and
Aims
Meteorin‐like
protein
(Metrnl)
has
been
recently
suggested
as
a
new
adipokine
with
protective
cardiovascular
effects.
Its
circulating
levels
in
patients
seem
to
be
associated
heart
failure
(HF),
although
contradictory
results.
Our
aim
was
ascertain
whether
this
could
estimate
the
prognosis
of
HF
de
novo
(DNHF)
patients.
Methods
Metrnl
plasma
400
hospitalized
DNHF
(55%
reduced
ejection
fraction,
17.3%
mid‐range
27.8%
preserved
fraction)
were
measured
by
enzyme‐linked
immunosorbent
assay.
We
performed
both
sex‐pooled
sex‐specific
analyses.
A
12‐month
follow‐up
conducted,
during
which
clinical
outcomes
such
all‐cause
mortality,
death
re‐hospitalization
due
collected.
Results
After
follow
up,
higher
an
increased
risk
for
after
adjusting
sex,
age,
LVEF,
hypertension,
diabetes,
ischemic
aetiology,
chronic
renal
failure,
NT‐proBNP
troponin
(hazard
ratio
[HR]
=
1.003,
95%
confidence
interval
[CI]
1.000–1.005;
p
‐value<.05
HR
1.004,
CI
1.001–1.007,
‐value<.05,
respectively).
In
line
this,
had
number
occurrences
events.
Regarding
associations
parameters
implicated
development
progression
HF,
we
found
that
positively
correlated
age
(
r
.322,
‐value<.0001),
.281,
‐value<.0001)
dysfunction
markers
urea
creatinine
.353,
women
than
men
(473.7
[385.9–594.0]
pg/mL
vs.
428.7
[349.1–561.3]
pg/mL,
‐value<.006).
Finally,
concerning
subtype
fraction.
Conclusion
Patients
have
worse
DNHF.
results
reinforce
association
outcomes.
Язык: Английский
Metrnl and Cardiomyopathies: From Molecular Mechanisms to Therapeutic Insights
Journal of Cellular and Molecular Medicine,
Год журнала:
2025,
Номер
29(2)
Опубликована: Янв. 1, 2025
ABSTRACT
Cardiomyopathies,
a
diverse
group
of
diseases
affecting
the
heart
muscle,
continue
to
pose
significant
clinical
challenges
due
their
complex
aetiologies
and
limited
treatment
options
targeting
underlying
genetic
molecular
dysregulations.
Emerging
evidence
indicates
that
Metrnl,
myokine,
adipokine
cardiokine,
plays
role
in
pathogenesis
various
cardiomyopathies.
Therefore,
objective
this
review
is
examine
mechanism
Metrnl
cardiomyopathies,
with
expectation
providing
new
insights
for
these
diseases.
Язык: Английский
Metrnl plays a crucial role in the regulation of glycolipid metabolism
Metabolism and Target Organ Damage,
Год журнала:
2025,
Номер
5(1)
Опубликована: Янв. 25, 2025
An
imbalance
in
the
metabolism
of
glycolipids
largely
causes
numerous
metabolic
diseases
that
negatively
affect
human
health.
Metrnl
plays
an
important
role
glycolipid
and
regulates
glucose
lipid
through
multiple
mechanisms.
However,
expression
level
related
to
remains
controversial.
can
increase
utilization
by
tissue
cells
reduce
adverse
effects
a
high-glucose
environment
on
body;
metabolism,
it
composition
blood
lipids,
accumulation
fat,
promote
browning
white
fat.
The
clinical
efficacy
exogenously
administered
recombinant
needs
be
further
investigated
verified.
This
review
presents
overview
Metrnl,
emphasizing
its
association
with
diseases.
It
offers
theoretical
foundation
for
treatment
metabolism-related
conditions.
Язык: Английский
Skeletal muscle growth to combat diabetes and obesity: the potential role of muscle‐secreted factors
Obesity,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
Abstract
As
the
prevalence
of
obesity
and
metabolic
disease
continues
to
climb,
need
for
effective
therapeutic
interventions
remains
high.
The
growth
skeletal
muscle
(SkM)
greatly
influences
systemic
metabolism
across
whole
body,
making
this
tissue
an
important
target
combat
rise
dysfunction.
Transgenic
rodent
models
targeted
SkM
exhibit
profound
improvements
in
various
remote
tissues,
including
adipose
liver.
It
is
currently
unclear
how
selective
stimulation
alters
distant
tissues;
however,
evidence
suggests
that
muscle‐secreted
factors
may
be
involved.
Here,
we
aim
provide
basic
biomedical
researchers
with
a
summary
current
knowledge
regarding
regulated
by
anabolic
pathways
proteins
SkM,
as
well
their
effects,
implicate
them
whole‐body
effects
growth.
In
review,
also
identify
several
gaps
field,
future
directions
investigation,
implications
such
resistance
exercise
pharmacology.
image
Язык: Английский
The Association Between Plasma Metrnl and Insulin Resistance Among Vietnamese Type 2 Diabetes Patients with or Without Dyslipidemia
Bratislavské lekárske listy/Bratislava medical journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Язык: Английский
Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2770 - 2770
Опубликована: Март 19, 2025
Insulin
resistance
(IR)
is
a
significant
factor
in
the
development
and
progression
of
metabolic-related
diseases
like
dyslipidemia,
T2DM,
hypertension,
nonalcoholic
fatty
liver
disease,
cardiovascular
cerebrovascular
disorders,
cancer.
The
pathogenesis
IR
depends
on
multiple
factors,
including
age,
genetic
predisposition,
obesity,
oxidative
stress,
among
others.
Abnormalities
insulin-signaling
cascade
lead
to
host,
insulin
receptor
abnormalities,
internal
environment
disturbances,
metabolic
alterations
muscle,
liver,
cellular
organelles.
complex
multifaceted
characteristics
signaling
envisage
their
thorough
comprehensive
understanding
at
molecular
level.
Therapeutic
strategies
for
include
exercise,
dietary
interventions,
pharmacotherapy.
However,
there
are
still
gaps
be
addressed,
more
precise
biomarkers
associated
chronic
lifestyle
interventions
needed.
Understanding
these
pathways
essential
developing
effective
treatments
IR,
reducing
healthcare
costs,
improving
quality
patient
life.
Язык: Английский