Diagnostic and Therapeutic Implications of the SUMOylation Pathway in Acute Myeloid Leukemia

Cancers, Год журнала: 2025, Номер 17(4), С. 631 - 631

Опубликована: Фев. 13, 2025

Epigenetics encompasses heritable and stable changes in gene expression caused by external chromosomal modifications, without altering the underlying DNA sequence. Epigenetic established during early development maintained through successive cell divisions, play a critical role regulating expression. Post-translational modifications (PTMs) are key aspect of epigenetics essential for modulating protein functionality, as well regulatory cellular processes, including proliferation, differentiation, metabolic pathways, tumorigenic events. Among these, small ubiquitin-related modifier (SUMOylation) system is reversible PTM mechanism that alters target interaction surfaces covalent binding to lysine residues, thereby influencing structure function. Acute myeloid leukemia (AML) highly aggressive malignancy characterized clonal expansion primitive hematopoietic stem cells lineage bone marrow. Despite recent advancements therapeutic strategies an improved understanding leukemogenic patient outcomes remain poor, particularly elderly populations. Consequently, efforts have focused on developing novel agents, co-targeting specific mutations or integrating targeted therapies into combinatorial chemotherapeutic regimens. Emerging evidence suggests SUMOylation plays significant AML pathogenesis treatment response, representing promising advanced disease cases. This review provides brief analysis functional highlights its potential target. We also discuss current knowledge gaps propose directions future research advance precision medicine approaches treatment.

Язык: Английский

Rhythms in Remodeling: Posttranslational Regulation of Bone by the Circadian Clock

Biomedicines, Год журнала: 2025, Номер 13(3), С. 705 - 705

Опубликована: Март 13, 2025

The circadian clock is a fundamental timekeeping system that regulates rhythmic biological processes in response to environmental light–dark cycles. In mammals, core genes (CLOCK, BMAL1, PER, and CRY) orchestrate these rhythms through transcriptional–translational feedback loops, influencing various physiological functions, including bone remodeling. Bone homeostasis relies on the coordinated activities of osteoblasts, osteoclasts, osteocytes, with increasing evidence highlighting role regulation maintaining skeletal integrity. Disruptions are linked disorders such as osteoporosis. Posttranslational modifications (PTMs), phosphorylation, acetylation, ubiquitination, serve crucial regulators both mechanisms metabolism. However, specific PTMs integrating timing remodeling remains underexplored. This review examines intersection biology, elucidating their impact cell function homeostasis. Understanding interactions may uncover novel therapeutic targets for diseases associated disruptions.

Язык: Английский

Identification of SUMOylation-related signature genes associated with immune infiltration in ulcerative colitis through bioinformatics analysis and experimental validation

Gene, Год журнала: 2024, Номер 935, С. 148996 - 148996

Опубликована: Окт. 10, 2024

Язык: Английский