Опубликована: Окт. 23, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1910 - 1910
Опубликована: Фев. 23, 2025
Reductive stress (RS), characterized by excessive accumulation of reducing equivalents such as NADH and NADPH, is emerging a key factor in metabolic disorders cancer. While oxidative (OS) has been widely studied, RS its complex interplay with endocrine regulation remain less understood. This review explores molecular circuits bidirectional crosstalk between hormones RS, focusing on their role diabetes, obesity, cardiovascular diseases, disrupts insulin secretion signaling, exacerbates inflammation, contributes to adipose tissue dysfunction, ultimately promoting resistance. In alters vascular smooth muscle cell function myocardial metabolism, influencing ischemia-reperfusion injury outcomes. cancer, plays dual role: it enhances tumor survival buffering OS reprogramming, yet can trigger proteotoxicity mitochondrial leading apoptosis. Recent studies have identified RS-targeting strategies, including redox-modulating therapies, nanomedicine, drug repurposing, offering potential for novel treatments. However, challenges remain, particularly distinguishing physiological from pathological conditions overcoming therapy-induced Future research should focus developing selective biomarkers, optimizing therapeutic interventions, exploring the immune regulation.
Язык: Английский
Процитировано
0
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 386 - 386
Опубликована: Янв. 9, 2025
The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(3), С. 204 - 204
Опубликована: Янв. 30, 2025
The epichaperome, a dynamic and integrated network of chaperone proteins, extends its roles beyond basic protein folding to stabilization intracellular signal transduction orchestrating multitude cellular processes critical for tumor survival. In this review, we explore the multifaceted delving into diverse locations, factors that modulate formation function, liquid–liquid phase separation, key signaling crosstalk pathways it regulates, including metabolism transduction. We further highlight techniques isolating identifying epichaperome networks, pitfalls, opportunities. Further, review profound implications cancer treatment therapy design, underscoring need strategic engineering hinges on comprehensive insight structure workings across heterogeneous cell subpopulations in milieu. By presenting holistic view epichaperome’s functions mechanisms, aim underscore potential as target novel anti-cancer strategies, revealing is not merely piece machinery but mastermind facilitates malignant phenotype.
Язык: Английский
Процитировано
0
eLife, Год журнала: 2025, Номер 14
Опубликована: Фев. 21, 2025
Nature has inspired the design of improved inhibitors for cancer-causing proteins.
Язык: Английский
Процитировано
0
Exploration of neuroscience, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Neurodegenerative disorders, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are among the most significant health concerns worldwide, characterized by neuronal dysfunction, oxidative stress, neuroinflammation, protein misfolding. Epigallocatechin gallate, a green tea polyphenol, has been reported to possess multifaceted neuroprotective properties. It reduces stress through free radical scavenging, activation of antioxidant enzymes, stabilization mitochondrial function. also inhibits neuroinflammation modulation key signaling pathways. suppresses amyloid-beta aggregation in Alzheimer’s alpha-synuclein fibrillation thus attenuating toxic accumulation. Its activity induction autophagy promotion synaptic plasticity supports survival However, low bioavailability metabolic instability hinder its translation into clinic. Strategies nanoparticle encapsulation, structural modifications, combination therapies being explored overcome these challenges. Future research could establish epigallocatechin gallate as viable candidate for managing neurodegenerative disorders.
Язык: Английский
Процитировано
0
Toxics, Год журнала: 2025, Номер 13(3), С. 178 - 178
Опубликована: Фев. 28, 2025
Billions of people are exposed to fine particulate matter (PM2.5) levels above the USEPA’s annual standard 9 μg/m3. Common emission sources anthropogenic, producing complex aerosolized toxins. Ultrafine (UFPM) and industrial nanoparticles (NPs) have major detrimental effects on brain, but USA does not measure UFPM a routine basis. This review focuses development progression common neurodegenerative diseases, as diagnosed through neuropathology, among young residents in Metropolitan Mexico City (MMC). MMC is one most polluted megacities world, with population 22 million residents, many whom unaware brain caused by their atmosphere. Fatal diseases (such Alzheimer’s Parkinson’s) that begin childhood populations living air environments preventable. We conclude UFPM/NPs capable disrupting neural homeostasis give rise relentless processes throughout entire life highly MMC. The paradigm reaching old age neurodegeneration no longer supported. Neurodegenerative changes start early pediatric ages irreversible. It time invest preventive medicine.
Язык: Английский
Процитировано
0
Computational Biology and Chemistry, Год журнала: 2025, Номер 117, С. 108415 - 108415
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
0
Drug Resistance Updates, Год журнала: 2025, Номер 81, С. 101228 - 101228
Опубликована: Март 9, 2025
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(3), С. 404 - 404
Опубликована: Март 12, 2025
Aging is a complex, progressive, and irreversible biological process that entails numerous structural functional changes in the organism. These affect all bodily systems, reducing their ability to respond adapt environment. Chronic inflammation one of key factors driving development age-related diseases, ultimately causing substantial decline abilities older individuals. This persistent inflammatory state (commonly known as “inflammaging”) characterized by elevated levels pro-inflammatory cytokines, an increase oxidative stress, perturbation immune homeostasis. Several factors, including cellular senescence, contribute this milieu, thereby amplifying conditions such cardiovascular disease, neurodegeneration, metabolic disorders. Exploring mechanisms chronic aging essential for developing targeted interventions aimed at promoting healthy aging. review explains strong connection between inflammation, highlighting potential therapeutic approaches like pharmacological treatments, dietary strategies, lifestyle changes.
Язык: Английский
Процитировано
0
Chinese Journal of Integrative Medicine, Год журнала: 2025, Номер unknown
Опубликована: Март 25, 2025
Язык: Английский
Процитировано
0