Опубликована: Окт. 23, 2024
Язык: Английский
Cellular and Molecular Neurobiology, Год журнала: 2025, Номер 45(1)
Опубликована: Март 26, 2025
Worldwide aging has contributed to the growth of prevalence neurodegenerative diseases (NDDs), including Parkinson's disease among elderlies. The advanced destruction dopaminergic neurons in substantia nigra, due many accelerator factors brain is main mechanism disease. pathological aggregated alpha-synuclein (α-syn), a protein implicated multiple disorders, one critical this and other similar disorders. misfolding aggregation α-syn may interrupt processes, functions synaptic vesicles can lead neuronal death. This encoded by Alpha-Synuclein Gene (SNCA) mutation gene dysfunctions structure. Since, therapeutic policies that aim are promising approaches. Advances immunotherapies, molecular chaperones, therapy targeting SNCA, DNA aptamers some examples strategy. review aims comprehensively assess current knowledge evidence on pathology, genetic determinants, novel methods Parkinson,'s synucleinopathies. Continued investigation discover interventions system could result finding effective safe treatments for NDDs.
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 486 - 486
Опубликована: Март 28, 2025
This comprehensive review examines the therapeutic potential of metformin, a well-established diabetes medication, in treating neurodegenerative disorders. Originally used as first-line treatment for type 2 diabetes, recent studies have begun investigating metformin’s effects beyond metabolic disorders, particularly its neuroprotective capabilities against conditions like Parkinson’s disease, Alzheimer’s Huntington’s and multiple sclerosis. Key findings demonstrate that operate through pathways: AMPK activation enhancing cellular energy metabolism autophagy; upregulation antioxidant defenses; suppression inflammation; inhibition protein aggregation; improvement mitochondrial function. These mechanisms collectively address common pathological features neurodegeneration neuroinflammation, including oxidative stress, accumulation, dysfunction. Clinical preclinical evidence supporting association with improved cognitive performance, reduced risk dementia, modulation hallmarks diseases is critically evaluated. While metformin shows promise agent, this emphasizes need further investigation to fully understand optimal applications diseases.
Язык: Английский
Процитировано
0
Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Март 26, 2025
Язык: Английский
Процитировано
0
Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(4), С. 259 - 259
Опубликована: Апрель 8, 2025
Chronic pain, defined by persistent pain beyond normal healing time, is a pervasive and debilitating condition affecting up to 30–50% of adults globally. In parallel, neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS) are characterized progressive neuronal loss cognitive or motor decline, often underpinned pathological protein misfolding aggregation. Emerging evidence suggests potential mechanistic link between chronic NDs, with contributing neuroinflammatory states homeostasis disturbances that mirror processes in neurodegeneration. This review explores the hypothesis aggregation serve bridge We systematically examine molecular pathways misfolding, proteostasis dysfunction shared neuroimmune mechanisms, highlighting prion-like propagation misfolded proteins, neuroinflammation, oxidative stress common denominators. further discuss from experimental models clinical studies linking accelerated pathology—including tau accumulation, amyloid dysregulation, microglial activation—and consider how these insights open avenues for novel therapeutics. Targeting aggregation, enhancing chaperone function, modulating unfolded response (UPR), attenuating glial activation explored strategies mitigate possibly slow Understanding this intersection not only elucidates pain’s role decline but also interventions addressing inflammation could yield dual benefits management modification.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3658 - 3658
Опубликована: Апрель 12, 2025
This narrative review presents the role of antioxidants in regulating gut microbiota and impact on gut–brain axis, with a particular focus neurodegenerative diseases, such as Alzheimer’s (AD) Parkinson’s disease (PD). These diseases are characterised by cognitive decline, motor dysfunction, neuroinflammation, all which significantly exacerbated oxidative stress. elucidates contribution damage to progression explores potential mitigate these pathological processes through modulation associated pathways. Based recent studies retrieved from reputable databases, including PubMed, Web Science, Scopus, this article outlines mechanisms influence health exert neuroprotective effects. Specifically, it discusses how antioxidants, polyphenols, vitamins, flavonoids, contribute reduction reactive oxygen species (ROS) production thereby promoting neuronal survival minimising brain. In addition, modulating key molecular pathways involved stress NF-κB, Nrf2, MAPK, PI3K/AKT pathways, regulate ROS generation, inflammatory cytokine expression, antioxidant responses essential for maintaining cellular homeostasis both central nervous system. complex relationship between gut-derived metabolites, stress, highlighting dysbiosis—an imbalance microbiota—can exacerbate accelerating AD PD. The also examines short-chain fatty acids (SCFAs) produced beneficial bacteria attenuate neuroinflammation damage. Furthermore, therapeutic microbiota-targeted interventions, delivery probiotics prebiotics, innovative strategies restore microbial support brain health. By synthesising current knowledge interplay underlying neurodegeneration, highlights promise antioxidant-based interventions mitigating progression. It need further research into antioxidant-rich dietary microbiota-focused therapies promising avenues prevention treatment diseases.
Язык: Английский
Процитировано
0
Greener Journal of Biomedical and Health Sciences, Год журнала: 2025, Номер 8(1), С. 16 - 27
Опубликована: Март 10, 2025
Biometals are essential to many physiological functions, including the normal functioning and development of brain. Notably, altered levels these biometals in body have been observed patients living with neurodegenerative conditions like Alzheimer’s, Huntington’s, Parkinson’s, Amyotrophic Lateral Sclerosis. This review will establish how can enter accumulate mechanisms for exhibiting neurotoxic effects. Correlations between level other non-essential metals existence diseases make them worthy study. Researchers looked toward biometal homeostasis as potential sources biomarkers, diagnostic breakthroughs, therapeutic solutions conditions. In addition, we explore benefit brain health, their role conditions, next frontiers biometal-based diagnostics therapy research.
Язык: Английский
Процитировано
0
Advances in protein chemistry and structural biology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 326, С. 125288 - 125288
Опубликована: Окт. 16, 2024
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 57 - 57
Опубликована: Дек. 25, 2024
As the organism ages, there is a decline in effective energy supply, and this retards ability to elaborate new proteins. The consequences of are especially marked gradual brain function. senescence cells their constituent organelles ultimately cause aging entire nervous system. What less immediately obvious that also accompanied by failure catabolic events lead removal non-functional ineffective subcellular components. non-working cellular elements within essential order allow appearance fresh with full range capacities. Thus, maintenance operative mechanisms for dispersal failed tissue components important, its diminished capacity significant contributory factor onset progression age-related neurological disorder. This report discusses underlying autophagy phagocytosis how these can be adversely modulated as proceeds. means which recycling may reinstated aged considered.
Язык: Английский
Процитировано
0
Опубликована: Окт. 23, 2024
Язык: Английский
Процитировано
0