Unraveling the Role of Fusobacterium nucleatum in Colorectal Cancer: Molecular Mechanisms and Pathogenic Insights
Cancers,
Год журнала:
2025,
Номер
17(3), С. 368 - 368
Опубликована: Янв. 23, 2025
Fusobacterium
nucleatum,
a
gram-negative
anaerobic
bacterium,
has
emerged
as
significant
player
in
colorectal
cancer
(CRC)
pathogenesis.
The
bacterium
causes
persistent
inflammatory
reaction
the
mucosa
by
stimulating
release
of
pro-inflammatory
cytokines
like
IL-1β,
IL-6,
and
TNF-α,
creating
an
environment
conducive
to
progression.
F.
nucleatum
binds
penetrates
epithelial
cells
through
adhesins
such
FadA,
impairing
cell
junctions
encouraging
epithelial-to-mesenchymal
transition
(EMT),
which
is
associated
with
advancement.
Additionally,
modulates
host
immune
system,
suppressing
activity
conditions
favorable
for
tumor
growth.
Its
interactions
gut
microbiome
contribute
dysbiosis,
further
influencing
carcinogenic
pathways.
Evidence
indicates
that
can
inflict
DNA
damage
either
directly
via
reactive
oxygen
species
or
indirectly
environment.
it
triggers
oncogenic
pathways,
especially
Wnt/β-catenin
signaling
pathway,
promotes
growth
longevity.
Moreover,
alters
microenvironment,
impacting
behavior,
metastasis,
therapeutic
responses.
purpose
this
review
elucidate
molecular
mechanisms
contributes
CRC.
Understanding
these
crucial
development
targeted
therapies
diagnostic
strategies
CRC
nucleatum.
Язык: Английский
Fecal Microbiota Strongly Correlates with Tissue Microbiota Composition in Colorectal Cancer but Not in Non-Small Cell Lung Cancer
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 717 - 717
Опубликована: Янв. 16, 2025
Microbiota
could
be
of
interest
in
the
diagnosis
colorectal
and
non-small
cell
lung
cancer
(CRC
NSCLC).
However,
how
microbial
components
tissues
feces
reflect
each
other
remains
unknown.
In
this
work,
our
main
objective
is
to
discover
degree
correlation
between
composition
tissue
microbiota
that
patients
affected
by
CRC
NSCLC.
Specifically,
we
investigated
tumor
non-tumor
from
38
recruited
with
19
DNA
samples
was
submitted
for
16S
rDNA
metagenomic
sequencing,
followed
data
analysis
through
QIIME2
pipeline
further
statistical
processing
STATA
IC16.
Tumor
selected
genera
were
highly
correlated
both
NSCLC
(100%
81.25%).
Following
this,
established
tissue-feces
correlations,
using
a
LEfSe
previously
published.
CRC,
found
strong
taxa
detected
those
tissues.
do
not
demonstrate
conclusion,
findings
strongly
reinforce
utility
fecal
as
non-invasive
biomarker
diagnosis,
while
highlighting
critical
distinctions
Furthermore,
are
similar,
only
minor
differences
being
detected.
Язык: Английский
Oxidative Stress by H2O2 as a Potential Inductor in the Switch from Commensal to Pathogen in Oncogenic Bacterium Fusobacterium nucleatum
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 323 - 323
Опубликована: Март 7, 2025
Background:
Fusobacterium
nucleatum
is
a
pathobiont
that
plays
dual
role
as
both
commensal
and
pathogen.
The
oral
cavity
typically
harbors
this
anaerobic,
Gram-negative
bacterium.
At
the
same
time,
it
closely
linked
to
colorectal
cancer
due
its
potential
involvement
in
tumor
progression
resistance
chemotherapy.
mechanism
by
which
transforms
from
pathogen
remains
unknown.
For
reason,
we
investigated
of
oxidative
status
an
initiatory
factor
changing
bacterium’s
pathogenicity
profile.
Methods:
A
clinical
strain
F.
subsp.
animalis
biofilm
was
exposed
different
stress
levels
through
varying
subinhibitory
amounts
H2O2.
Subsequently,
behavior
vitro
infecting
HT-29
cell
line.
We
evaluated
bacterial
colonization,
volatile
sulfur
compounds
production,
infected
cell’s
analyzing
HMOX1,
pri-miRNA
155,
146a
gene
expression.
Results:
colonization
rate,
dimethyl
sulfide
155
all
increased
when
stressed
bacteria
were
used,
suggesting
predominant
pathogenic
function
these
strains.
Conclusions:
response
conditions
could
potentially
explain
increase
traits
existence
environmental
factors
may
trigger
virulence.
Язык: Английский
Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment
Journal of Immunology Research,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Colorectal
cancer
(CRC)
stands
as
one
of
the
tumors
with
globally
high
incidence
and
mortality
rates.
In
recent
years,
researchers
have
extensively
explored
role
tumor
immune
microenvironment
(TME)
in
CRC,
highlighting
crucial
influence
cell
populations
driving
progression
shaping
therapeutic
outcomes.
The
TME
encompasses
an
array
cellular
noncellular
constituents,
spanning
cells,
myeloid
tumor-associated
fibroblasts,
among
others.
However,
composition
within
is
highly
dynamic,
evolving
throughout
different
stages
progression.
These
shifts
subpopulation
proportions
lead
to
a
gradual
transition
response,
shifting
from
early
antitumor
growth
late-stage
environment
that
supports
survival.
Therefore,
it
further
investigate
understand
complex
interactions
various
TME.
this
review,
we
explore
key
components
varying
origins,
subpopulations
shared
elements
CRC
TME,
examining
their
interconnections
critical
considerations
for
developing
personalized
precise
immunotherapy
strategies.
Язык: Английский
Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3733 - 3733
Опубликована: Апрель 15, 2025
The
gut
microbiome,
a
complex
community
of
microorganisms
residing
in
the
intestinal
tract,
plays
dual
role
colorectal
cancer
(CRC)
development,
acting
both
as
contributing
risk
factor
and
protective
element.
This
review
explores
mechanisms
by
which
microbiota
contribute
to
CRC,
emphasizing
inflammation,
oxidative
stress,
immune
evasion,
production
genotoxins
microbial
metabolites.
Fusobacterium
nucleatum,
Escherichia
coli
(pks+),
Bacteroides
fragilis
promote
tumorigenesis
inducing
chronic
generating
reactive
oxygen
species,
producing
virulence
factors
that
damage
host
DNA.
These
can
also
evade
antitumor
response
suppressing
cytotoxic
T
cell
activity
increasing
regulatory
populations.
Additionally,
microbial-derived
metabolites
such
secondary
bile
acids
trimethylamine-N-oxide
(TMAO)
have
been
linked
carcinogenic
processes.
Conversely,
microbiota,
including
Lactobacillus,
Bifidobacterium,
Faecalibacterium
prausnitzii,
homeostasis
short-chain
fatty
(SCFAs)
like
butyrate,
exhibit
anti-inflammatory
anti-carcinogenic
properties.
beneficial
microbes
enhance
barrier
integrity,
modulate
responses,
inhibit
tumor
proliferation.
Understanding
dynamic
interplay
between
pathogenic
is
essential
for
developing
microbiome-based
interventions,
probiotics,
prebiotics,
fecal
transplantation,
prevent
or
treat
CRC.
Future
research
should
focus
on
identifying
biomarkers
early
CRC
detection
exploring
personalized
microbiome-targeted
therapies.
A
deeper
understanding
host–microbiota
interactions
may
lead
innovative
strategies
management
improved
patient
outcomes.
Язык: Английский
Bacteria and Carcinogenesis and the Management of Cancer: A Narrative Review
Pathogens,
Год журнала:
2025,
Номер
14(5), С. 509 - 509
Опубликована: Май 21, 2025
There
is
a
widely
known
relationship
between
certain
microbes
and
cancer
progression.
For
instance,
Helicobacter
pylori
associated
with
the
occurrence
of
gastric
cancer,
while
HPV
cervical
head
neck
cancers.
Recent
studies
have
uncovered
novel
important
associations
bacterial
presence
tumor
formation
treatment
response.
Apart
from
influence
intestinal
microbiome
on
local
activity
bacteria
affects
disease
properties
as
well.
Bacteria
can
localize
within
tumors
in
less
vascularized
niches.
Their
mediates
signaling
pathways,
which
contribute
to
tumorigenesis.
Furthermore,
they
affect
composition
microenvironment,
highly
complex
structure
composed
immunoregulatory
cells
secreted
inflammatory
mediators.
Recently,
researchers
analyzed
develop
anticancer
strategies.
The
aim
this
review
discuss
latest
findings
regarding
relationships
that
could
be
used
kill
cells.
Язык: Английский