Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis
Metabolites,
Год журнала:
2025,
Номер
15(1), С. 59 - 59
Опубликована: Янв. 16, 2025
Background/Objectives:
Sarcopenia,
characterized
by
the
progressive
loss
of
muscle
mass
and
strength,
is
linked
to
physical
disability,
metabolic
dysfunction,
an
increased
risk
mortality.
Exercise
therapy
currently
acknowledged
as
a
viable
approach
for
addressing
sarcopenia.
Nevertheless,
molecular
mechanisms
behind
exercise
training
or
activity
remain
poorly
understood.
The
disruption
mitochondrial
homeostasis
implicated
in
pathogenesis
effectively
delays
onset
sarcopenia
significantly
maintaining
homeostasis,
including
promoting
mitophagy,
improving
biogenesis,
balancing
dynamics,
redox.
Exerkines
(e.g.,
adipokines,
myokines,
hepatokines,
osteokines),
signaling
molecules
released
response
training,
may
potentially
contribute
skeletal
metabolism
through
ameliorating
reducing
inflammation,
regulating
protein
synthesis
defense
against
Methods:
In
this
review,
we
provide
detailed
summary
exercise-induced
exerkines
confer
their
benefit,
with
particular
focus
on
impact
context
Results:
induces
substantial
adaptations
muscle,
mass,
improved
regeneration
hypertrophy,
elevated
hormone
release,
enhanced
function.
An
expanding
body
research
highlights
that
have
potential
regulate
processes
such
autophagy,
redox
balance.
These
maintenance
thereby
supporting
health.
Conclusions:
Through
comprehensive
investigation
within
mitochondria,
reveals
new
insights
into
key
exercise-protective
sensors
combating
Язык: Английский
Reactive Oxygen Species (ROS) in Metabolic Disease—Don’t Shoot the Metabolic Messenger
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2622 - 2622
Опубликована: Март 14, 2025
Reactive
oxygen
species
(ROS)
are
widely
considered
key
to
pathogenesis
in
chronic
metabolic
disease.
Consequently,
much
attention
is
rightly
focused
on
minimising
oxidative
damage.
However,
for
ROS
production
be
most
effectively
modulated,
it
crucial
first
appreciate
that
do
not
solely
function
as
pathological
mediators.
There
>90
gene
products
specifically
evolved
generate,
handle,
and
tightly
buffer
the
cellular
concentration
of
ROS.
Therefore,
likely
plays
a
role
integral
homeostatic
signalling
components
only
become
toxic
extremis.
This
review
explores
these
commonly
overlooked
normal
physiological
functions,
including
how
generated
response
environmental
or
hormonal
stimuli,
mechanisms
by
which
signals
propagated
regulated,
cell
brings
signal
an
end
after
appropriate
duration.
In
course
this,
several
specific
better-characterised
rely
upon
explored,
threshold
at
cross
from
beneficial
molecules
pathology
mediators
discussed.
Язык: Английский