Immune Modulation and Immunotherapy in Solid Tumors: Mechanisms of Resistance and Potential Therapeutic Strategies DOI Open Access

Suman Giri,

Gopal Lamichhane, Jitendra Pandey

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2923 - 2923

Опубликована: Март 24, 2025

Understanding the modulation of specific immune cells within tumor microenvironment (TME) offers new hope in cancer treatments, especially immunotherapies. In recent years, and resistance to immunotherapy have become critical challenges treatments. However, novel strategies for emerged as promising approaches oncology due vital roles immunomodulators regulating progression metastasis modulating immunological responses standard care With progress immuno-oncology, a growing number mechanisms are being uncovered, offering potential enhanced clinical near future. Thus, gaining comprehensive understanding broader context is essential. Herein, we particularly summarize paradoxical role tumor-related cells, focusing on how targeted their actions modulated by immunotherapies overcome immunotherapeutic cells. We also highlight molecular employed tumors evade long-term effects agents, rendering them ineffective.

Язык: Английский

Immune Modulation and Immunotherapy in Solid Tumors: Mechanisms of Resistance and Potential Therapeutic Strategies DOI Open Access

Suman Giri,

Gopal Lamichhane, Jitendra Pandey

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2923 - 2923

Опубликована: Март 24, 2025

Understanding the modulation of specific immune cells within tumor microenvironment (TME) offers new hope in cancer treatments, especially immunotherapies. In recent years, and resistance to immunotherapy have become critical challenges treatments. However, novel strategies for emerged as promising approaches oncology due vital roles immunomodulators regulating progression metastasis modulating immunological responses standard care With progress immuno-oncology, a growing number mechanisms are being uncovered, offering potential enhanced clinical near future. Thus, gaining comprehensive understanding broader context is essential. Herein, we particularly summarize paradoxical role tumor-related cells, focusing on how targeted their actions modulated by immunotherapies overcome immunotherapeutic cells. We also highlight molecular employed tumors evade long-term effects agents, rendering them ineffective.

Язык: Английский

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