Different Forms of Regulated Cell Death in Type-2-Diabetes-Mellitus-Related Osteoporosis: A Focus on Mechanisms and Therapeutic Strategies DOI Open Access

Chenchen Li,

He Gong,

Peipei Shi

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4417 - 4417

Опубликована: Май 6, 2025

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with high prevalence and challenging treatment options. It significantly affects the function of various organs, including bones, imposes substantial social economic costs. Chronic hyperglycemia, insulin resistance, abnormalities in glucolipid metabolism can lead to cellular damage within body. Bone dysfunction represents significant characteristic diabetic osteoporosis (DOP). Recent studies confirm that cell death critical factor contributing bone damage. Regulated (RCD) highly controlled process involves numerous proteins specific signaling cascades. RCD processes, apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, cuproptosis, may be linked cells T2DM. In this review, types populations during pathogenic DOP were explored, link between processes pathogenesis was further explored. addition, research progress on targeting for summarized paper. This provide foundation additional explorations drug development, as well new therapeutic concepts clinical management DOP.

Язык: Английский

Different Forms of Regulated Cell Death in Type-2-Diabetes-Mellitus-Related Osteoporosis: A Focus on Mechanisms and Therapeutic Strategies DOI Open Access

Chenchen Li,

He Gong,

Peipei Shi

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4417 - 4417

Опубликована: Май 6, 2025

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with high prevalence and challenging treatment options. It significantly affects the function of various organs, including bones, imposes substantial social economic costs. Chronic hyperglycemia, insulin resistance, abnormalities in glucolipid metabolism can lead to cellular damage within body. Bone dysfunction represents significant characteristic diabetic osteoporosis (DOP). Recent studies confirm that cell death critical factor contributing bone damage. Regulated (RCD) highly controlled process involves numerous proteins specific signaling cascades. RCD processes, apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, cuproptosis, may be linked cells T2DM. In this review, types populations during pathogenic DOP were explored, link between processes pathogenesis was further explored. addition, research progress on targeting for summarized paper. This provide foundation additional explorations drug development, as well new therapeutic concepts clinical management DOP.

Язык: Английский

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