The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies

Molecular Cancer, Год журнала: 2022, Номер 21(1)

Опубликована: Сен. 8, 2022

Abstract Given that hypoxia is a persistent physiological feature of many different solid tumors and key driver for cancer malignancy, it thought to be major target in treatment recently. Tumor-associated macrophages (TAMs) are the most abundant immune cells tumor microenvironment (TME), which have large impact on development immunotherapy. TAMs massively accumulate within hypoxic regions. represent deadly combination because has been suggested induce pro-tumorigenic macrophage phenotype. Hypoxia not only directly affects polarization, but also an indirect effect by altering communication between macrophages. For example, can influence expression chemokines exosomes, both profound impacts recipient cells. Recently, demonstrated intricate interaction TME relevant poor prognosis increased malignancy. However, there no comprehensive literature reviews molecular mechanisms underlying hypoxia-mediated TAMs. Therefore, this review aim collect all recently available data topic provide insights developing novel therapeutic strategies reducing effects hypoxia.

Язык: Английский

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Exosomes: A potential tool for immunotherapy of ovarian cancer

Frontiers in Immunology, Год журнала: 2023, Номер 13

Опубликована: Янв. 18, 2023

Ovarian cancer is a malignant tumor of the female reproductive system, with very poor prognosis and high mortality rates. Chemotherapy radiotherapy are most common treatments for ovarian cancer, unsatisfactory results. Exosomes subpopulation extracellular vesicles, which have diameter approximately 30–100 nm secreted by many different types cells in various body fluids. highly stable effective carriers immunotherapeutic drugs. Recent studies shown that exosomes involved cellular responses microenvironment, influencing development therapeutic efficacy exhibiting dual roles inhibiting promoting development. also contain variety genes related to immunotherapy could be potential biomarkers diagnosis prognosis. Undoubtedly, great field immunotherapy. However, translation this idea clinic has not occurred. Therefore, it important understand how used regulate progression. In review, we summarize fluids mechanisms influence response. We discuss prospects clinical application exosome-based cancer.

Язык: Английский

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ncRNA-mediated ceRNA regulatory network: Transcriptomic insights into breast cancer progression and treatment strategies

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114698 - 114698

Опубликована: Апрель 13, 2023

With the rapid development of next-generation sequencing technology, several studies have shown that ncRNAs can act as competitive endogenous RNAs (ceRNAs) and are involved in various biological processes, such proliferation, differentiation, apoptosis, migration breast cancer (BC) cells, plays an important role BC progression a molecular target for its diagnosis, treatment, prognosis, differentiation subtypes age groups patients. Based on description ceRNA-related functions, this study screened sorted analysis experimental verification conclusions BC-related ceRNAs found mediated ceRNA networks promote by promoting expression genes related to drug resistance, inducing production epithelial-mesenchymal transition (EMT) metastasis activating cancer-related signaling pathways.

Язык: Английский

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Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(12), С. 6480 - 6480

Опубликована: Июнь 9, 2022

Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in intracellular communication through EV-encapsulated informative content, including proteins, lipids, and nucleic acids. Mesenchymal stem cells (MSCs) pluripotent with self-renewal ability derived from bone marrow, fat, umbilical cord, menstruation blood, pulp, etc., which they use to induce tissue regeneration by their direct recruitment into injured tissues, the heart, liver, lung, kidney, or secreting factors, such as vascular endothelial growth factor insulin-like factor. Recently, MSC-derived EVs have been shown regenerative effects against various diseases, partially due post-transcriptional regulation of target genes miRNAs. Furthermore, garnered attention novel drug delivery systems, because can specially encapsulate molecules. In this review, we summarize molecular mechanisms EVs.

Язык: Английский

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Exosome derived from tumor-associated macrophages: biogenesis, functions, and therapeutic implications in human cancers

Biomarker Research, Год журнала: 2023, Номер 11(1)

Опубликована: Ноя. 19, 2023

Abstract Tumor-associated macrophages (TAMs), one of the most abundant immune cell types in tumor microenvironment (TME), account for approximately 50% local hematopoietic cells. TAMs play an important role tumorigenesis and development through crosstalk between various cells cytokines TME. Exosomes are small extracellular vesicles with a diameter 50–150 nm, that can transfer biological information (e.g., proteins, nucleic acids, lipids) from secretory to recipient circulatory system, thereby influencing progression human diseases, including cancer. Recent studies have suggested TAMs-derived exosomes crucial roles malignant proliferation, invasion, metastasis, angiogenesis, responses, drug resistance, metabolic reprogramming. potential be targeted therapy. In addition, abnormal expression non-coding RNAs proteins is closely related clinicopathological features patients cancer, these expected become new liquid biopsy markers early diagnosis, prognosis, monitoring tumors. this review, we explored provide diagnostic biomarkers therapeutic targets cancer prevention.

Язык: Английский

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Emerging role of exosomes as a liquid biopsy tool for diagnosis, prognosis & monitoring treatment response of communicable & non-communicable diseases

The Indian Journal of Medical Research, Год журнала: 2024, Номер 159(2), С. 163 - 163

Опубликована: Янв. 1, 2024

From an initial thought of being used as a cellular garbage bin to promising target for liquid biopsies, the role exosomes has drastically evolved in just few years their discovery 1983. Exosomes are naturally secreted nano-sized vesicles, abundant all types body fluids and can be isolated intact even from stored biological samples. Being stable carriers genetic material (cellular DNA, mRNA miRNA) having specific cargo (signature content originating cells), play crucial pathogenesis have been identified novel source biomarkers variety disease conditions. Recently emerged 'liquid biopsy tool'and shown great potential field non-invasive diagnostics, prognostics treatment response monitoring both communicable well non-communicable diseases. However, there certain limitations overcome which restrict use exosome-based gold standard testing procedure routine clinical practices. The present review summarizes current knowledge on tool diagnosis, prognosis diseases highlights major limitations, technical advancements future prospects utilization interventions.

Язык: Английский

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Exosomal circular RNAs: New player in breast cancer progression and therapeutic targets

Frontiers in Genetics, Год журнала: 2023, Номер 14

Опубликована: Фев. 28, 2023

Breast cancer is the most prevalent type of malignancy among women. Exosomes are extracellular vesicles cell membrane origin that released via exocytosis. Their cargo contains lipids, proteins, DNA, and different forms RNA, including circular RNAs. Circular RNAs new class non-coding with a closed-loop shape involved in several types cancer, breast cancer. contained lot circRNAs which called exosomal circRNAs. By interfering biological pathways, can have either proliferative or suppressive role The involvement has been studied consideration to tumor development progression as well its effects on therapeutic resistance. However, exact mechanism still unclear, there not available clinical implications exo-circRNAs Here, we highlight recent potential circRNAas targets diagnostics for

Язык: Английский

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Role of circular RNAs in disease progression and diagnosis of cancers: An overview of recent advanced insights

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 220, С. 973 - 984

Опубликована: Авг. 14, 2022

Язык: Английский

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Non-Coding RNAs Modulating Estrogen Signaling and Response to Endocrine Therapy in Breast Cancer

Cancers, Год журнала: 2023, Номер 15(6), С. 1632 - 1632

Опубликована: Март 7, 2023

The largest part of human DNA is transcribed into RNA that does not code for proteins. These non-coding RNAs (ncRNAs) are key regulators protein-coding gene expression and have been shown to play important roles in health, disease therapy response. Today, endocrine ERα-positive breast cancer (BC) a successful treatment approach, but resistance this major clinical problem. Therefore, deeper understanding mechanisms overcome resistance. An increasing amount evidence demonstrate ncRNAs affect the response therapy. Thus, considered versatile biomarkers predict or monitor In review article, we intend give summary update on effects microRNAs (miRNAs), long (lncRNAs) circular (circRNAs) estrogen signaling BC cells, pathway being target therapy, their role For purpose, reviewed articles these topics listed PubMed database. Finally, provide an assessment regarding use ncRNA types, particularly circulating forms, as predictive potential targets

Язык: Английский

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Transforming native exosomes to engineered drug vehicles: A smart solution to modern cancer theranostics

Biotechnology Journal, Год журнала: 2024, Номер 19(2)

Опубликована: Фев. 1, 2024

Abstract Exosomes have been the hidden treasure of cell in terms cellular interactions, transportation and therapy. The native exosomes (NEx) secreted by parent cells hold promising aspects cancer diagnosis NEx has low immunogenicity, high biocompatibility, toxicity stability which enables them to be an ideal prognostic biomarker diagnosis. However, due heterogeneity, lacks specificity accuracy used as therapeutic drug delivery vehicle Transforming these with their innate structure multiple receptors engineered (EEx) can provide better opportunities field theranostics. surface exhibits numeric modified pave direction its Through membrane, EEx increased loading potentiality higher target act a nanocarrier for delivery. This review provides insights into tool along need transformation We also highlighted different methods associated transformations, nano‐bio interaction recipient major challenges clinical application

Язык: Английский

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