Dietary patterns and cardiometabolic health: Clinical evidence and mechanism

MedComm, Год журнала: 2023, Номер 4(1)

Опубликована: Фев. 1, 2023

Abstract For centuries, the search for nutritional interventions to underpin cardiovascular treatment and prevention guidelines has contributed rapid development of field dietary patterns cardiometabolic disease (CMD). Numerous studies have demonstrated that healthy with emphasis on food‐based recommendations are gold standard extending lifespan reducing risks CMD mortality. Healthy include various permutations energy restriction, macronutrients, food intake such as calorie intermittent fasting, Mediterranean diet, plant‐based diets, etc. Early implementation in patients is encouraged, but an understanding mechanisms by which these trigger benefits remains incomplete. Hence, this review examined several may improve health, including restrictive patterns, regional diets based controlled macronutrients groups, summarizing cutting‐edge evidence potential treatment. Particularly, considering individual differences responses composition changes organ tissue diversity, we highlighted critical role gut microbiota crosstalk between diet recommend a more precise dynamic strategy developing profiles.

Язык: Английский

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Pro‐inflammatory cytokines IL‐1α, IL‐6 and TNF‐α in major depressive disorder: Sex‐specific associations with psychological symptoms

European Journal of Neuroscience, Год журнала: 2023, Номер 57(11), С. 1913 - 1928

Опубликована: Апрель 18, 2023

Abstract The pro‐inflammatory cytokines IL‐1α, IL‐6 and TNF‐α are associated with major depressive disorder, psychological distress, cardiovascular health obesity. However, there is limited research that has examined multiple associations between these variables, particularly among individuals disorder who treatment free, in comparison a control cohort, including analyses of sex differences. In this study, data were analysed from 60 controls, plasma TNF‐α, adiposity measures (body mass index, waist circumference), indices (blood pressure, heart rate) symptoms (depressive severity, anxiety, hostility, stress). compared by group correlated adiposity, health. Plasma IL‐1α higher versus control, but interaction for IL‐6, difference only females. did not differ groups. hostility stress, whereas anxiety hostility. Psychopathology was males females only. None the body circumference, blood pressure or rate. result sex‐specific psychometrics could be aetiologically important depression interventions treatments males, warranting further investigation.

Язык: Английский

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Association between air pollution and lifestyle with the risk of developing mild cognitive impairment and dementia in individuals with cardiometabolic diseases

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 15, 2025

Abstract Lifestyle factors and ambient air pollution are linked to dementia CMDs, yet few studies have investigated their impact on risk in CMDs patients at the same time. The Cox proportional hazards model was used evaluate influence of lifestyle population among 438,681 participants UK Biobank. It is found that developing mild cognitive impairment seems increase with number CMDs. There appears be a statistically significant association between high levels pollution, unhealthy lifestyles, higher population. healthy may an effect modifier role development Therefore, maybe people can lessen by improving lifestyle.

Язык: Английский

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Long-term lifestyle change and risk of mortality and Type 2 diabetes in patients with cardiovascular disease

European Journal of Preventive Cardiology, Год журнала: 2023, Номер 31(2), С. 205 - 213

Опубликована: Сен. 29, 2023

Abstract Aims To quantify the relationship between self-reported, long-term lifestyle changes (smoking, waist circumference, physical activity, and alcohol consumption) clinical outcomes in patients with established cardiovascular disease (CVD). Methods results Data were used from 2011 participants (78% male, age 57 ± 9 years) Utrecht Cardiovascular Cohort—Second Manifestations of ARTerial cohort who returned for a re-assessment visit (SMART2) after ∼10 years. Self-reported change was classified as persistently healthy, improved, worsened, or unhealthy. Cox proportional hazard models to risk (cardiovascular) mortality incident Type 2 diabetes (T2D). Fifty-seven per cent 17% improved their lifestyle, 8% During median follow-up time 6.1 (inter-quartile range 3.6–9.6) years SMART2 visit, 285 deaths occurred, 99 new T2D diagnoses made. Compared unhealthy individuals maintained healthy had lower all-cause [hazard ratio (HR) 0.48, 95% confidence interval (CI) 0.36–0.63], (HR 0.57, CI 0.38–0.87), 0.46, 0.28–0.73). Similarly, those 0.52, 0.37–0.74), 0.26–0.81), 0.50, 0.27–0.92). Conclusion These findings suggest that maintaining adopting can significantly CVD patients. This study emphasizes importance ongoing optimization patients, highlighting potential positive regardless previous habits.

Язык: Английский

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From gut to placenta: understanding how the maternal microbiome models life-long conditions

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Дек. 15, 2023

The microbiome -defined as the microbiota (bacteria, archaea, lower and higher eukaryotes), their genomes, surrounding environmental conditions- has a well-described range of physiological functions. Thus, an imbalance composition -dysbiosis- been associated with pregnancy complications or adverse fetal outcomes. Although there is controversy about existence absence in placenta fetus during healthy pregnancy, it known that gut can produce bioactive metabolites enter maternal circulation may be actively passively transferred through placenta. Furthermore, evidence suggests such have some effect on fetus. Since influence epigenome, modifications epigenome could responsible for programming, experimentally supported its involved programming. developmental origin health disease (DOHaD) approach looks to understand how exposure factors periods high plasticity early stages life (e.g., gestational period) influences program risk progeny. Therefore, according DOHaD approach, development must explored. Here, we described diseases adulthood related alterations microbiota. In summary, this review aims highlight both postnatal life, suggesting dysbiosis morbidity.

Язык: Английский

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Mortality and Years of Life Lost From Cardiometabolic Diseases in Mexico: National and State-Level Trends, 1998-2022

Public Health Reports, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Cardiometabolic diseases (CMDs) are highly prevalent in Mexico. We analyzed the evolution of mortality from CMDs Mexico at national and state level, as well their contribution to years life lost (YLL), 1998 through 2022. conducted an observational study based on a public database. calculated age-standardized rates, joinpoint regression analyses determine changes trend magnitude over time, YLL among people nationally by state. From 2022, rate increased 14.9% These rates reached highest levels 2020 2021 during COVID-19 pandemic. In aged 0 84 had 3.9 CMDs, which represented increase 0.4 compared with 1998. for heart disease, diabetes mellitus, hypertension but decreased stroke. Mortality have steadily Mexico, driven mainly disease mellitus. attributable could be prevented early care health prevention policies. Decision makers should work implement robust enduring policies focused shared risk factors underlying these diseases.

Язык: Английский

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Scaling up structured lifestyle interventions to improve the management of cardiometabolic diseases in low-income and middle-income countries: a systematic review of strategies, methods and outcomes

BMJ Public Health, Год журнала: 2025, Номер 3(1), С. e001371 - e001371

Опубликована: Янв. 1, 2025

Cardiometabolic diseases (CMDs), the leading causes of death in low-income and middle-income countries (LMICs), are proven to be mitigated through structured lifestyle interventions (SLIs-dietary changes, physical activity, tobacco cessation alcohol intake), but challenge lies scaling them up LMICs. Therefore, we undertook a systematic review identify strategies, methods outcomes used SLI programmes improve cardiometabolic We searched studies implementing scale-up strategies (delivery approaches enhancing an intervention's adoption, implementation sustainability), (theories, models frameworks) present (feasibility, fidelity, etc) following Proctor E framework. six databases published English with no time restriction, guided by Setting, Perspective, Intervention, Comparison Evaluation Quality assessment was performed using Cochrane risk-of-bias, National Institutes Health Joanna Briggs Institute tools. Given heterogeneity outcome measures, conducted narrative synthesis extracted information. Out 26 included, 18 (69%) adapted suit local contexts. Strategies such as system integration, strengthening facility services training led 100% attendance participants. Notably, only four (15%) theories, frameworks for full process, which is crucial large-scale resource-limited settings. 15 (58%) reported feasibility scale-up, whereas 7 (27%) significant differences behaviours or CMD biomarkers. Early community stakeholders' engagement codeveloping SLIs. Conducting readiness assessments integration all essential considerations improving outcomes. Additionally, strongly recommend suitable guide SLIs maximise benefit population.

Язык: Английский

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Development, Validation, and Usability Evaluation of an Application for Health Education in Individuals With Cardiometabolic Diseases

CIN Computers Informatics Nursing, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Mobile applications are effective tools for health education in cardiometabolic diseases, enhancing patient's self-care, self-management, self-efficacy, and treatment adherence. This study describes the development, validation, evaluation of usability a mobile application aimed at individuals with diseases. is methodological developed using theoretical-methodological framework Systematic Instructional Design. The validity educational technology was assessed content index, threshold 80% or higher. application's evaluated through System Usability Scale. Viva+ Flutter, Dart programming language Firebase database. It comprises 49 screens features functionalities such as registration, login, usage instructions, quizzes, note-taking, guidance pages covering topics contextualization risk factors, healthy eating, physical activity, weight control, medication management, adherence, smoking alcohol consumption, sleep improvement, stress professional follow-up. deemed valid by experts, achieving global index 0.99. Regarding usability, it obtained total score 78.07, being considered excellent. shown to be valid, suitable, comprehensive, relevant promotion

Язык: Английский

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Association between physical activity and sedentary behavior with cardiometabolic multimorbidity in the elderly hypertensive population: an observational and Mendelian randomization study

Psychology of sport and exercise, Год журнала: 2025, Номер unknown, С. 102869 - 102869

Опубликована: Май 1, 2025

Язык: Английский

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Association of physical activity and trajectories of physical activity with cardiovascular disease

Expert Review of Cardiovascular Therapy, Год журнала: 2023, Номер 21(2), С. 87 - 96

Опубликована: Янв. 27, 2023

Prolonged sedentary life existence is associated with increased incidence of cardiovascular disease (CVD), coronary heart (CHD), obesity, type 2 diabetes mellitus (T2DM), hypertension, failure (HF), and all-cause mortality. On the contrary, regular exercise known from antiquity to be beneficial (CV) effects decreased mortality.The benefits have been confirmed by many studies, but trajectories different modes PA are not well recognized. In order examine modalities its long-term trajectories, a Medline search English literature was conducted between 2015 2022 60 pertinent papers were selected for review.Careful review showed that CV mediated through several favorable modifications molecular clinical factors. Also, any physical activity in conjunction lifestyle adjustments CVD, CHD, T2DM, HF, addition, regarding duration level greater effects, even resumption discontinued can lead effects.

Язык: Английский

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