Immunity & Ageing, Год журнала: 2024, Номер 21(1)
Опубликована: Ноя. 13, 2024
Preventing metabolic syndrome (MetS) and frailty in older adults is crucial for healthy aging. The association between MetS physical well-documented, with low-grade inflammation as potential explanation. However, the a multidimensional concept, of presence frailty, yet unclear. Therefore, we examined these associations large cohort community-dwelling adults.
Язык: Английский
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Июнь 5, 2024
Background Metabolic syndrome (MetS) is a global health concern, and it particularly harmful to middle-aged elderly individuals. Life Element Eight (LE8), measure improve cardiovascular health, may offer benefits for MetS. Herein, we examined the relationship between LE8 MetS among individuals, elucidated role of biological aging inflammation in this process. Methods We obtained scores 2,901 Americans, along with their indicators (Biological age, Phenotypic Serum Klotho), computed inflammatory SII, DII. Using logistic regression model, assessed association markers, Biological aging, Additionally, generated restricted cubic spline (RCS) plots display trends significant variables regression. parallel mediation analysis, evaluated possible mediating various factors risk Results Our examination revealed that higher were associated lower incidence fully adjusted model. The high subgroup had 79.73% reduction compared low an OR = 0.2027 (95% Cl 0.0871, 0.4714), similar correlations factor risk. mediated associations LE8, behaviors Conclusion A rise score individuals protective MetS, be partially by suggesting reduce ameliorating aging.
Язык: Английский
Процитировано
11
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 12, 2025
The relationship between lifestyle choices and health outcomes has received significant scholarly attention. Research indicates that factors such as obesity, insufficient physical activity, tobacco use, poor dietary habits may elevate the odds of developing metabolic disorders. This study aimed to investigate association combined healthy score (HLS) syndrome (MetS) its associated components in a population apparently adults. cross-sectional utilized data from Dena PERSIAN cohort, which comprised 2,971 Participants' HLS were evaluated using validated questionnaires assessed body mass index (BMI), activity level (PAL), smoking status, quality. evaluation nutritional quality was conducted most recent version Healthy Eating Index (HEI), known HEI-2020. measured on scale ranging zero, indicating an unhealthy lifestyle, four, representing healthiest lifestyle. Individuals with highest had 81% lower having MetS compared those lowest (OR: 0.19; 95% CI: 0.11–0.33). Higher scores significantly decreased abdominal adiposity 0.11; 0.07–0.18), abnormal glucose homeostasis 0.55; 0.35–0.86), elevated serum triglycerides 0.41; 0.26–0.67), low high-density lipoprotein cholesterol (HDL-C) levels 0.39; 0.24–0.65) after adjusting for sex, age, education level, marital status (P < 0.05). findings indicated adherence among Iranian
Язык: Английский
Процитировано
2
Frontiers in Medicine, Год журнала: 2025, Номер 11
Опубликована: Янв. 15, 2025
The difference between the estimated glomerular filtration rate (eGFR) calculated from cystatin C and creatinine (eGFRdiff) serves as a biomarker of kidney function impairment. However, role eGFRdiff in cardiovascular-kidney-metabolic (CKM) health its impact on mortality CKM syndrome patients has not yet been studied. This study included 3,622 participants National Health Nutrition Examination Survey (NHANES) conducted 1999 2004. Weighted ordinal logistic regression was used to explore link health, while weighted Cox examine relationship patients. Restricted cubic splines (RCSs) were analyze dose-response relationship. common odds ratio (cOR) per 10 mL/min/1.73m2 increase 0.86 [95% confidence interval (CI), 0.81 0.91]. Compared midrange eGFRdiff, cOR values for negative positive 1.88 CI, 1.23 2.88] 0.69 0.58 0.83], respectively. During median follow-up 201 months, 853 died all causes, 265 due cardiovascular causes. hazard ratios (HRs) 0.88 0.83 0.93] all-cause 0.90 1.00] cases. with those had 48% higher risk mortality, 30% lower risk. No significant non-linear associations found these analyses. Our that is associated stratified
Язык: Английский
Процитировано
1
Ageing Research Reviews, Год журнала: 2023, Номер 92, С. 102121 - 102121
Опубликована: Ноя. 8, 2023
Aging is widespread worldwide and a significant risk factor for cardiovascular disease (CVD). Mechanisms underlying aging have attracted considerable attention in recent years. Remarkably, CVD overlap numerous ways, with deregulated nutrient sensing as common mechanism lifestyle communal modifier. Interestingly, triggers or suppresses multiple nutrient-related signaling pathways. In this review, we first present the composition of nutrient-sensing network (NSN) its metabolic impact on CVD. Secondly, review how factors closely associated CVD, including adverse life states such sedentary behavior, sleep disorders, high-fat diet, psychosocial stress, contribute to focus bridging role NSN. Finally, positive effects beneficial dietary interventions, specifically restriction Mediterranean regulation metabolism delayed that depend balance summary, expound interaction between lifestyle, NSN, aging,
Язык: Английский
Процитировано
22
BMC Oral Health, Год журнала: 2024, Номер 24(1)
Опубликована: Фев. 4, 2024
Abstract Background Periodontitis is closely associated with chronic systemic diseases. Healthy lifestyle interventions have health-enhancing effects on disorders and periodontitis, but the extent to which healthy combinations are periodontitis unclear. Therefore, this study aimed investigate association between different combinations. Methods 5611 participants were included from National Health Nutrition Examination Survey (NHANES, 2009–2014). Six lifestyles factors defined as fulfilling either: non-smoking, moderate drinking, body mass index (BMI), physical activity, sleep appropriate total energy intake. Then, adjusted logistic regression models performed identify scoring system composed of six (0–6 scale). Finally, scenarios dynamically randomly combined optimal personalized combination mode. Results Higher scores significantly lower prevalence ( p < 0.05). Four (smoking, BMI, sleep) varied groups Smoking was considered a strong independent risk factor for in both former current smokers. further indicated that these four played most essential role determining magnitude occurrence (odds ratio [OR]: 0.33; 95% confidence interval [CI]: 0.21 0.50). In population, majority three outperformed two models, whereas two-combination nonsmoking-drinking (OR: 0.39; CI: 0.27 0.58) had relatively than three-combination drinking-BMI-sleep 0.42; 0.26 0.66). Conclusion This cross-sectional suggests smoking, related smoking principal among them. provides various customized prevention.
Язык: Английский
Процитировано
8
International Journal of Medical Informatics, Год журнала: 2024, Номер 188, С. 105480 - 105480
Опубликована: Май 9, 2024
Язык: Английский
Процитировано
6
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Июль 24, 2024
Metabolic syndrome (MetS) is a cluster of medical conditions and risk factors correlating with insulin resistance that increase the developing cardiometabolic health problems. The specific criteria for diagnosing MetS vary among different organizations but are typically based on evaluation abdominal obesity, high blood pressure, hyperglycemia, dyslipidemia. A unique, quantitative independent estimation only biomarkers highly desirable comparison between patients to study individual progression disease in manner.
Язык: Английский
Процитировано
3
Cancers, Год журнала: 2025, Номер 17(3), С. 426 - 426
Опубликована: Янв. 27, 2025
Background/Objectives: Cancer prevalence is increasing globally due to aging populations. Certain lifestyles are associated with cancer; however, the long-term combined effects of lifestyle factors on cancer has not been investigated. This study aimed investigate cumulative effect risk over 8 years in older Korean men. Methods: We assessed 64,756 men aged ≥65 at baseline year (2008–2009) using data from National Health Insurance Service-Senior Cohort. Lifestyle factors, including smoking status, alcohol consumption, and physical activity, were evaluated four consecutive phases (2002–2003, 2004–2005, 2006–2007, 2008–2009) health check-ups, each participant’s overall score was calculated after considering value a single poor factor phase as 1, ranging between 0 12. According scores, hazard ratios (HRs) 95% confidence intervals (CIs) Cox proportional regression analysis. Results: Of men, 13,130 cases developed. The increased number during phases. Compared 0–2, HRs for 1.10 (0.98–1.23), 1.54 (1.37–1.73), 1.72 (1.48–1.99) scores 3–5, 6–8, 9–12, respectively. Conclusions: burden habits increased. Therefore, practicing maintaining healthy crucial preventing
Язык: Английский
Процитировано
0
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Март 20, 2025
Periodontitis is the major cause of tooth loss in adults and one most common non-communicable diseases. Clinically, periodontitis impairs oral health associated with various systemic Maintaining a healthy diet considered risk reduction periodontitis. To explore causal effect between dietary data by Mendelian randomization (MR) analyses. A total 11,704 participants 21 variables from NHANES were random forest to rank importance predicting Data genome wide association studies (GWASs) database estimate relationships Two-sample MR analyses conducted using inverse-variance weighted (IVW) method. The showed alcohol consumption sugars intake increased chronic odds ratio (OR) 2.768 (95% CI: 1.03e + 00–7.42e 00) 2.123 1.06e 00–4.26e respectively. Vitamins minerals, including folic acid folate, magnesium, vitamin A, E, C, calcium, D zinc, not causally Alcohol greater than 2.5 drinks per day sugar more 4.88 g periodontitis, calculated relative 1.33 1.61, It suggested drink less drinks/day consume g/day avoid promoting development Establishing pattern conducive periodontal may be focus further clinical research.
Язык: Английский
Процитировано
0
BMC Oral Health, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 10, 2025
Recent studies have reported an association between toothbrushing frequency and systemic health. Plaque control, achieved through frequent brushing, is known to prevent dental caries periodontal disease, potentially reducing the risk of diseases. However, individuals with good oral health behaviours may also exhibit healthier lifestyle habits which could impact In examining relationship health, it important consider influence factors that mediate them. This study conducted mediation analyses evaluate extent status Health examinations, including assessments, were performed on 15,579 at Aichi Promotion Foundation. Of these, 12,540 participants aged 40-74 years included in analysis. Mediation using number metabolic syndrome (MS) components as outcome variable, (regular visits, use interdental brushes or floss, frequency) exposure variables, (smoking, drinking, exercise, eating habits) mediators, age sex covariates. Regular visits showed significant total indirect effects MS, although no direct effect was observed. The floss demonstrated total, MS. Exercise habits, mediators regular These significantly influenced associations both MS mediated by status. Among mediating variables tested this study, diet exercise tended be stronger than disease. Oral their habits.
Язык: Английский
Процитировано
0