Pharmacological Reviews,
Год журнала:
2024,
Номер
77(2), С. 100033 - 100033
Опубликована: Дек. 24, 2024
Cancer
and
cardiovascular
disease
(CVD)
are
the
2
biggest
killers
worldwide.
Specific
treatments
have
been
developed
for
diseases.
However,
mutual
therapeutic
targets
should
be
considered
because
of
overlap
cellular
molecular
mechanisms.
research
has
grown
at
a
fast
pace,
leading
to
an
increasing
number
new
mechanistic
treatments.
Some
these
drugs
could
prove
useful
treating
CVD,
which
realizes
concept
cancer
drug
repurposing.
This
review
provides
comprehensive
outline
shared
hallmarks
primarily
ischemic
heart
failure.
We
focus
on
chronic
inflammation,
altered
immune
response,
stromal
vascular
cell
activation,
underlying
signaling
pathways
causing
pathological
tissue
remodeling.
There
is
obvious
scope
targeting
those
mechanisms,
thereby
achieving
reciprocal
preventive
benefits.
Major
attention
devoted
illustrating
logic,
advantages,
challenges,
viable
examples
repurposing
discussing
potential
influence
sex,
gender,
age,
ethnicity
in
realizing
this
approach.
Artificial
intelligence
will
help
refine
personalized
application
patients
with
CVD.
SIGNIFICANCE
STATEMENT:
(CVD),
worldwide,
share
several
So
far,
specific
therapies
tackle
development
slow
compared
drugs.
Understanding
intersection
between
mechanisms
diseases
basis
therapeutics
CVD
treatment.
approach
allow
rapid
CVDs.
Antioxidants and Redox Signaling,
Год журнала:
2024,
Номер
40(7-9), С. 369 - 432
Опубликована: Фев. 1, 2024
Physiological
levels
of
reactive
oxygen
and
nitrogen
species
(ROS/RNS)
function
as
fundamental
messengers
for
many
cellular
developmental
processes
in
the
cardiovascular
system.
ROS/RNS
involved
cardiac
redox-signaling
originate
from
diverse
sources,
their
are
tightly
controlled
by
key
endogenous
antioxidant
systems
that
counteract
accumulation.
However,
dysregulated
redox-stress
resulting
inefficient
removal
leads
to
inflammation,
mitochondrial
dysfunction,
cell
death,
contributing
development
progression
disease
(CVD).
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Июль 18, 2024
Abstract
Mitochondria
play
a
central
role
in
cellular
energy
metabolism,
and
their
dysfunction
is
increasingly
recognized
as
critical
factor
the
pathogenesis
of
diabetes-related
cardiac
pathophysiology,
including
vulnerability
to
ischemic
events
that
culminate
myocardial
infarction
on
one
hand
ventricular
arrhythmias
other.
In
diabetes,
hyperglycemia
altered
metabolic
substrates
lead
excessive
production
reactive
oxygen
species
(ROS)
by
mitochondria,
initiating
cascade
oxidative
stress
damages
mitochondrial
DNA,
proteins,
lipids.
This
injury
compromises
efficiency
phosphorylation,
leading
impaired
ATP
production.
The
resulting
deficit
damage
contribute
functional
abnormalities
cells,
placing
heart
at
an
increased
risk
electromechanical
irreversible
cell
death
response
insults.
While
mitochondria
are
often
considered
be
relatively
autonomous
entities
capacity
produce
ROS,
highly
dynamic
nature
within
elaborate
network
closely-coupled
organelles
occupies
30–40%
cardiomyocyte
volume
fundamental
ability
exert
intricate
regulation
over
global
function.
this
article,
we
review
evidence
linking
properties
overall
function
its
injury.
We
then
highlight
select
studies
ultrastructural
alterations
driven
changes
fission,
fusion
mitophagy
promoting
diabetic
heart.
Cancers,
Год журнала:
2024,
Номер
16(3), С. 521 - 521
Опубликована: Янв. 25, 2024
Obesity
is
a
global
health
challenge
with
increasing
prevalence,
and
its
intricate
relationship
cancer
has
become
critical
concern
in
care.
As
result,
understanding
the
multifactorial
connections
between
obesity
breast
imperative
for
risk
stratification,
tailored
screening,
rehabilitation
treatment
planning
to
address
long-term
survivorship
issues.
The
review
follows
SANRA
quality
criteria
includes
an
extensive
literature
search
conducted
PubMed/Medline,
Web
of
Science,
Scopus.
biological
basis
linking
involves
complex
interactions
adipose
tissue
tumor
microenvironment.
Various
mechanisms,
such
as
hormonal
alterations,
chronic
inflammation,
immune
system
modulation,
mitochondrial
dysfunction,
contribute
development.
underlines
importance
comprehensive
oncologic
rehabilitation,
including
physical,
psychological,
nutritional
aspects.
Cancer
plays
crucial
role
managing
obesity-related
symptoms,
offering
interventions
physical
impairments,
pain
management,
lymphatic
disorders,
improving
both
psychological
well-being.
Personalized
technology-driven
approaches
hold
promise
optimizing
effectiveness
outcomes
obese
patients.
insights
provided
this
evolving
landscape
care,
emphasizing
well-being
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(8), С. 6749 - 6768
Опубликована: Апрель 4, 2024
Cardiovascular
diseases
(CVDs)
persist
as
the
predominant
cause
of
mortality,
urging
exploration
innovative
pharmaceuticals.
Mitochondrial
dysfunction
stands
a
pivotal
contributor
to
CVDs
development.
Sirtuin
3
(SIRT3),
prominent
mitochondrial
deacetylase
known
for
its
crucial
role
in
protecting
mitochondria
against
damage
and
dysfunction,
has
emerged
promising
therapeutic
target
treatment.
Utilizing
isosteviol,
natural
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 2677 - 2698
Опубликована: Фев. 1, 2025
To
investigate
the
role
of
mitochondrial
ribosomal
proteins
(MRPs)
in
pathogenesis
and
progression
septic
myocardial
injury.
Additionally,
we
aim
to
propose
new
technical
strategies
experimental
foundations
for
prevention
treatment
Animal
cell
models
injury
were
established.
Aberrantly
expressed
MRPs
screened
using
transcriptome
sequencing,
their
expression
was
verified
by
RT-qPCR
Western
blot.
Subsequently,
overexpressed
knockdown
constructed.
The
effects
on
CO
I,
PGC-1α,
ATP
content,
ROS
fluorescence
intensity,
membrane
potential,
GSDMD
assessed,
along
with
changes
caspase-4
IL-1β
levels.
Transcriptome
sequencing
revealed
a
reduction
mice
Both
blot
analysis
confirmed
decreased
animal
Furthermore,
overexpression
both
MRPS16
MRPL47
mitigated
decrease
I
PGC-1α
levels
induced
alleviated
elevated
IL-1β,
caspase-4,
caused
findings
suggest
that
can
mitigate
attenuating
biosynthesis
dysfunction,
energy
metabolism
disorders,
Ca2+
disturbances
This
ultimately
reduces
cellular
damage
alleviates
