Golden eagle optimized CONV-LSTM and non-negativity-constrained autoencoder to support spatial and temporal features in cancer drug response prediction DOI Creative Commons
Wesam Ibrahim Hajim, Suhaila Zainudin, Kauthar Mohd Daud

и другие.

PeerJ Computer Science, Год журнала: 2024, Номер 10, С. e2520 - e2520

Опубликована: Дек. 23, 2024

Advanced machine learning (ML) and deep (DL) methods have recently been utilized in Drug Response Prediction (DRP), these models use the details from genomic profiles, such as extensive drug screening data cell line data, to predict response of drugs. Comparatively, DL-based prediction approaches provided better features. However, prior knowledge, like pathway is sometimes discarded irrelevant since datasets are multidimensional noisy. Optimized feature extraction processes suggested handle this problem. First, noise class imbalance problems must be tackled avoid low identification accuracy, long times, poor applicability. This article aims apply Non-Negativity-Constrained Auto Encoder (NNCAE) network tackle issues, enhance adaptive search for optimal size sliding windows, ensure that architectures adept at vital hidden NNCAE methodology used after performing standard pre-processing procedures balanced noise-removed input features learned train proposed hybrid classifier. The classification model, Golden Eagle Optimization-based Convolutional Long Short-Term Memory neural networks (GEO-Conv-LSTM), assembled by integrating Neural Network CNN LSTM models, with parameter tuning performed GEO algorithm. Evaluations conducted on two large Genomics Sensitivity Cancer (GDSC) repository, NNCAE-GEO-Conv-LSTM-based approach has achieved 96.99% 97.79% accuracies, respectively, reduced processing time error rate DRP

Язык: Английский

The Complex Connection between Obesity and Cancer: Signaling Pathways and Therapeutic Implications DOI
Mohamed El‐Tanani, Syed Arman Rabbani, Alaa A. A. Aljabali

и другие.

Nutrition and Cancer, Год журнала: 2024, Номер 76(8), С. 683 - 706

Опубликована: Июнь 7, 2024

Obesity has emerged as an important global health challenge, significantly influencing the incidence and progression of various cancers. This comprehensive review elucidates complex relationship between obesity oncogenesis, focusing particularly on role dysregulated signaling pathways central mediators this association. We delve into contributions obesity-induced alterations in key cascades, including PI3K/AKT/mTOR, JAK/STAT, NF-κB, Wnt/β-catenin to carcinogenesis. These facilitate unchecked cellular proliferation, chronic inflammation apoptosis resistance. Epidemiological evidence links with increased cancer susceptibility adverse prognostic outcomes, pronounced risks for specific cancers such breast, colorectal, endometrial hepatic malignancies. synthesizes data from both animal clinical studies underscore pivotal disrupted shaping innovative therapeutic strategies. highlight critical importance lifestyle modifications management risk mitigation, stressing benefits dietary changes, physical activity, behavioral interventions. Moreover, we examine targeted pharmacological strategies addressing aberrant obesity-related tumors discuss integration cutting-edge treatments, immunotherapy precision medicine, practice.

Язык: Английский

Процитировано

1
Inverse FASN and LDHA correlation drives metabolic resistance in breast cancer DOI Creative Commons
Chiara Papulino, Ugo Chianese, Ahmad H. Ali

и другие.

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 24, 2024

Abstract Background Breast cancer manifests as a heterogeneous pathology marked by complex metabolic reprogramming essential to satisfy its energy demands. Oncogenic signals boost the metabolism, modifying fatty acid synthesis and glucose use from onset progression therapy resistant-forms. However, exact contribution of dependencies during tumor evolution remains unclear. Methods In this study, we elucidate connection between FASN LDHA, pivotal genes, their correlation with grade response using datasets public repositories. Subsequently, evaluated proliferative functions upon LDHA inhibition in breast models. Lastly, integrated metabolomic lipidomic analysis define contributions metabolites, lipids, precursors phenotypes. Results Collectively, our findings indicate shifts progression, unvealling two distinct functional phenotypes associated aggressiveness response. Specifically, exhibits reduced expression advance-grade tumors therapy-resistant forms, whereas demonstrates higher expression. Additionally, biological impact blocking enzymatic activity was correlated resistant conditions. Conclusions These observations emphasize intrinsic heterogeneity within cancer, thereby highlighting relevance interventions field precision medicine.

Язык: Английский

Процитировано

1
Enhancing breast cancer treatment through pharmacogenomics: A narrative review DOI
Ram Mohan Ram Kumar, Suresh Joghee

Clinica Chimica Acta, Год журнала: 2024, Номер 562, С. 119893 - 119893

Опубликована: Июль 26, 2024

Язык: Английский

Процитировано

1
siRNA-based knockdown of lncRNAs; a new modality to target tumor progression DOI

Abdulrahman Qais Khaleel,

Saade Abdalkareem Jasim, Soumya V. Menon

и другие.

Pathology - Research and Practice, Год журнала: 2024, Номер 266, С. 155746 - 155746

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

1
ZNAČAJ PRECIZNE MEDICINE I FARMAKOGENOMIKE U PREVENTIVNOJ PEDIJATRIJI DOI Open Access
Ivana Kavečan, Nataša Nikolić,

Đerđi Erdeš-Kavečan

и другие.

Deleted Journal, Год журнала: 2024, Номер unknown, С. 060 - 064

Опубликована: Март 21, 2024

Prevencija bolesti obuhvata sve aktivnosti koje se mogu sprovesti u cilju sprečavanja pojave i ispoljavanja manifestacija bolesti, kako bi rano otkrila bolest blagovremeno primenila odgovarajuća terapija. Primenama strategija precizne medicine uzimaju obzir genetičke analize, faktori spoljašnje sredine kao način na koji osoba živi, precizno odabralo lečenje je najprikladnije najefikasnije za tu osobu. Precizna medicina otvara novo poglavlje zdravstvene zaštite, preventivne pedijatrije. uključuje informacije dobijene genetičkim ispitivanjima – tzv. „OMIKAMA” (GEN-omika, TRANSKRIPT-omika, EPIGEN-omika, METABOL-omika, PROTE-omika, MIKROBI-omika), tj. tehnologijama analizama podataka pružaju precizan klinički, biološki molekularni fenotip. Unapređenje životnog stila izbegavanje štetnih faktora životne može uticati funkciju gena što iskoristiti prevenciji razvoju preciznih preventivnih zdravstvenih strategija.

Процитировано

0
Personalized precision medicine for oral oncology DOI Creative Commons

Rajiv Periakaruppan,

K. T. Abhishekh,

C. Nithya

и другие.

Oral Oncology Reports, Год журнала: 2024, Номер 10, С. 100301 - 100301

Опубликована: Апрель 4, 2024

• Oral squamous cell carcinoma (OSCC) is a highly prevalent form of cancer. Human papillomavirus (HPV) infection notable threat factor for oral

Язык: Английский

Процитировано

0
Sparstolonin B Reduces Estrogen-Dependent Proliferation in Cancer Cells: Possible Role of Ceramide and PI3K/AKT/mTOR Inhibition DOI Creative Commons
Yağmur Dilber, Tuğçe Çeker, Aleyna Öztüzün

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1564 - 1564

Опубликована: Ноя. 21, 2024

Background: The aim of this study was to determine the effect Sparstolonin B (SsnB) on cell proliferation and apoptosis in human breast cancer (MCF-7) ovarian epithelial (OVCAR-3) lines presence absence estradiol hemihydrate (ES). Phosphoinositol-3 kinase (PI3K), phosphorylated protein alpha (p-AKT), mTOR (mechanistic target rapamycin) signaling proteins, sphingomyelin/ceramide metabolites were also measured within scope study. Methods: anti-proliferative effects SsnB therapy evaluated over a range times concentrations. Cell determined by measuring Proliferating Nuclear Antigen (PCNA). PCNA quantified ELISA distribution assessed immunofluorescence microscopy. MTT analysis used test vitality cells, while LC-MS/MS analyze amounts ceramides (CERs), sphingosine-1-phosphate (S1P), sphingomyelins (SMs). TUNEL labeling assess apoptosis, staining enzyme-linked immunosorbent assay (ELISA) measure levels PI3K, p-AKT, p-mTOR proteins. Results: administration significantly decreased viability MCF-7 OVCAR-3 cells both ES, it did not cause toxicity healthy fibroblasts. In comparison controls, treated with showed significant drop S1P, p-mTOR. cultured SsnB, increase intracellular concentrations C16-C24 CERs observed. Conclusions: downregulated reducing promoting ceramide buildup apoptosis.

Язык: Английский

Процитировано

0
Exploring the antiproliferative and proapoptotic activities of new pyridopyrimidine derivatives and their analogs DOI

Hadeer M. Ali,

Mohamed A. Said, Shady Allam

и другие.

Bioorganic & Medicinal Chemistry, Год журнала: 2024, Номер 118, С. 118053 - 118053

Опубликована: Дек. 28, 2024

Язык: Английский

Процитировано

0
Need for Genome specific personalized medicines in ORAL CANCER? DOI Creative Commons
Chandrabose Selvaraj

Oral Oncology Reports, Год журнала: 2024, Номер 10, С. 100276 - 100276

Опубликована: Март 13, 2024

Язык: Английский

Процитировано

0
Analysis of PIK3CA mutations in the primary and recurrent tumors of hormone receptor positive/human epidermal growth factor receptor 2 negative breast cancer DOI
Yue Wang,

Xin Li,

Shuang Zhang

и другие.

Japanese Journal of Clinical Oncology, Год журнала: 2024, Номер 54(9), С. 1024 - 1031

Опубликована: Июнь 17, 2024

Our aim was to compare the PIK3CA mutation status in matched primary and recurrent tumors of hormone receptor positive/human epidermal growth factor 2 negative (HR+/HER2-) breast cancer (BC) gain insight into optimization patient selection detection time for PIK3CA-targeted therapy.

Язык: Английский

Процитировано

0